Expression of miR-126 and Crk in endometriosis: miR-126 may affect the progression of endometriosis by regulating Crk expression

Liu, Shuang; Gao, Shan; Wang, Xiaoying; Wang, Dan Bo

doi:10.1007/s00404-011-2112-6

Cited by 42 publications

(25 citation statements)

References 36 publications

(41 reference statements)

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“…Unfortunately, the ability of miR-126 to modulate cellular events conducive to endometriosis pathogenesis, such as cellular proliferation, adhesion, and/or invasion, was not evaluated in this study. It should also be noted that a more recent array analysis 27 observed decreased levels of ectopic endometrial tissue expression of miR-126 which is in agreement with the study by Liu and coworkers, 36 but in contrast to earlier array analysis reports. 22,23 …”

Section: Putative Targets Of and Functions For Specific Mirnas In Esupporting

confidence: 88%

“…34,35 Earlier reports 22,23 demonstrated increased expression of this miRNA in lesion tissue. Liu and colleagues, 36 in contrast, reported that miR-126 expression was significantly reduced in ovarian endometriomas and eutopic endometrium from women with endometriosis compared with eutopic endometrium from women free from the disease. Associated with this reduction in miR-126 was a significant increase in v-crk sarcoma virus CT10 oncogene homolog (CRK) mRNA and protein as well as a highly significant association between endometrioma and eutopic endometrial miR-126 expression.…”

Section: Putative Targets Of and Functions For Specific Mirnas In Ementioning

confidence: 94%

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MicroRNAs and Endometriosis: Distinguishing Drivers from Passengers in Disease Pathogenesis

Nothnick

2017

Semin Reprod Med

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Endometriosis is a disease common in women of reproductive age, characterized by pelvic pain and infertility. Despite its prevalence, the factors and mechanisms which contribute to the development and survival of ectopic lesions remain uncertain. MicroRNAs (miRNAs) are small RNA molecules that regulate posttranscriptional gene regulation which have been proposed to contribute to the pathogenesis of many diseases including that of endometriosis. This review summarizes the results of initial studies describing differentially expressed miRNAs between endometriotic lesion tissue and eutopic endometrium. Focus then moves toward discussion of studies on examining function of differentially expressed miRNAs to determine if they play a permissive role (driver of the disease) in events conducive to endometriosis progression/survival. Included in this discussion are the potential targets of these miRNAs and how their mis-expression may contribute to the disease. Limitations and challenges faced in studying miRNAs and endometriosis pathogenesis and recommendations to overcome these hurdles are presented at the end.

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Section: Putative Targets Of and Functions For Specific Mirnas In Esupporting

confidence: 88%

Section: Putative Targets Of and Functions For Specific Mirnas In Ementioning

confidence: 94%

MicroRNAs and Endometriosis: Distinguishing Drivers from Passengers in Disease Pathogenesis

Nothnick

2017

Semin Reprod Med

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“…miR-126 was reported to be downregulated and to act as a tumor suppressor in different cancers of the lung (10,11), stomach (12,13), cervix (14), bladder and prostate (15). miR-126 was also significantly downregulated in ectopic endometria (EC) versus eutopic endometria (EU), suggesting that it may play an initial role in the development and progression of endometriosis (Ems) (16). miR-126 might disturb vascular integrity, leading to a disorganized and abnormal tumor vasculature (17).…”

Section: Introductionmentioning

confidence: 99%

miR-126 inhibits growth of SGC-7901 cells by synergistically targeting the oncogenes PI3KR2 and Crk, and the tumor suppressor PLK2

Liu

Wang

Zhao

et al. 2014

International Journal of Oncology

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Abstract. MicroRNA (miRNA)-126 (miR-126) was reported to be downregulated and to act as a tumor suppressor in cancers of the lung, cervix, bladder and prostate. However, the functions of miR-126 in gastric cancer appear to be diverse and are largely unknown. MiR-126 was reported to act as a tumor suppressor by targeting the Crk gene, or as an oncogene by targeting the SOX2 gene in gastric cancer. We identified that the expression of miR-126 was decreased in gastric cancer cell lines and tissues. PLK2, a tumor suppressor gene, was directly regulated by miR-126 in SGC-7901 cells. Overexpression of miR-126 not only suppressed the growth and clone formation of SGC-7901 cells, but also induced apoptosis in vitro, whereas inhibition of miR-126 slightly promoted SGC-7901 cell proliferation. The cell cycle was not affected by miR-126. Moreover, miR-126 suppressed tumor growth in vivo in a xenograft model. PLK2, PI3KR2and Crk were regulated by miR-126 in SGC-7901 cells. We infer that the functions of miR-126 in gastric cancer depend on synergistic targeting balance between oncogenes and anti-oncogenes. Our study indicates that miR-126 is a tumor suppressor, which in the future may become a therapeutic target for gastric cancer.

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“…Additional miRNAs, which have been shown to be mis-expressed in endometriotic tissue include miR-199a (Dai et al 2012), miR-126 (Liu et al 2012), miR-23a/23b (Shen et al 2013) and miR-145 (Adammek et al 2013). It is well established that endometriosis is an invasive disease associated with increased angiogenesis, which often draws comparison to the malignant process.…”

Section: 3 Mirnas In Endometrial Physiology and Pathologymentioning

confidence: 99%

Non-coding RNAs in Uterine Development, Function and Disease

Nothnick

2015

Non-Coding RNA and the Reproductive System

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The major function of the uterus is to accept and provide a suitable environment for an embryo, ultimately leading the birth of offspring and successful propagation of the species. For this occur, there must be precise coordination of hormonal signalling within both the endometrial and myometrial components of this organ. Non-coding RNAs, specifically, microRNAs (miRNAs) have been shown to be essential for normal uterine development and function. Within this organ, miRNAs are proposed to fine-tune the actions of the female steroid hormones estradiol and progesterone. Not surprising, mis-expression of miRNAs has been documented in diseases of the endometrium and myometrium such as endometriosis and leiomyomas, respectively. In this chapter, I will review the current understanding on the role, regulation and function of non-coding RNAs focusing on miRNAs in both the normal physiology of the endometrium and myometrium as well as in pathologies of these tissues, namely endometriosis and leiomyomas.

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Expression of miR-126 and Crk in endometriosis: miR-126 may affect the progression of endometriosis by regulating Crk expression

Abstract: miR-126 may play an initial role in the development and progression of EMs. Crk may be regulated by miR-126, and synergism between abnormal expressions may play an important role in the pathogenesis of EMs.

Cited by 42 publications

References 36 publications

MicroRNAs and Endometriosis: Distinguishing Drivers from Passengers in Disease Pathogenesis

MicroRNAs and Endometriosis: Distinguishing Drivers from Passengers in Disease Pathogenesis

miR-126 inhibits growth of SGC-7901 cells by synergistically targeting the oncogenes PI3KR2 and Crk, and the tumor suppressor PLK2

Non-coding RNAs in Uterine Development, Function and Disease

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