Expression of microRNA-451 in normal and thalassemic erythropoiesis

Svasti, Saovaros; Masaki, Shizuka; Penglong, Tipparat; Abe, Yasunobu; Winichagoon, Pranee; Fucharoen, Suthat; Umemura, Tomonari

doi:10.1007/s00277-010-0980-7

Cited by 47 publications

(27 citation statements)

References 24 publications

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“…1c). Our results corroborate other results where thalassemic progenitors multiply more, but are slower in differentiation milestones, compared to their normal counterparts [7]. In our system the progenitor cells of normal donors multiplied ∼100 times, but in thalassemic individuals the increase is much greater.…”

Section: Figsupporting

confidence: 82%

hsa-miR-503 Is Downregulated in β Thalassemia Major

Roy

Bhattacharya²,

Lahiri³

et al. 2012

Acta Haematol

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Section: Figsupporting

confidence: 82%

hsa-miR-503 Is Downregulated in β Thalassemia Major

Roy

Bhattacharya²,

Lahiri³

et al. 2012

Acta Haematol

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“…Roughly a third of thalassemia patients are b0/b0 (Dehghanifard et al 2013). The resulting imbalance between the globin chains leads to alpha-chain accumulation in erythroid cells and subsequently to hemolytic anemia and ineffective erythropoiesis (Svasti et al 2010). These patients depend on regular transfusions for survival, a treatment which in itself complicates their condition by iron overload and precipitation in issues such as heart and liver (Musallam et al 2012).…”

Section: Introductionmentioning

confidence: 98%

The Influence of Polymorphisms in Disease Severity in β-Thalassemia

et al. 2015

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β-Thalassemia is a genetic disorder with a continuum of mild to severe clinical manifestations and requirement of transfusion at different stages of life. The cause(s) of this variety is not clear but genetic alterations could be a potential factor. In this review, the correlation between polymorphisms and different clinical manifestations, including the need for transfusion, was investigated. Relevant articles published in pubmed database from 1982 onwards were studied and compiled. The articles all contained the keywords β-thalassemia, genetic modifiers, and mutations. Certain polymorphisms and mutations could dictate the severity of symptoms as well as their onset. A significant number of the mentioned genetic alterations appear in beta-globin gene cluster and affect gamma chain. Therefore, hemoglobin F production rate is increased and can affect thalassemia symptoms and can relieve β-thalassemia symptoms. A number of polymorphisms in catalase and glutathione S transferase genes have also been shown to modify the severity of disease and response to treatment. Knowledge of these mutations and polymorphisms can provide an insight into the prognosis for individual patients, especially in young ages or before birth to take proper measures in advance and eventually ameliorate the symptoms in the long run.

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“…In addition, miR-451a was required for erythroid homeostasis [41]. Svasti S et al demonstrated that early erythroid progenitors in β-thalassemia have possessed a dysregulated miRNA-451a expression program [42].…”

Section: Oncotarget S474 Wwwimpactjournalscom/oncotargetmentioning

confidence: 99%

WITHDRAWN: Expression profiles and biological implications of plasma miRNAs associated with chronic myeloid leukemia phases

Zhang¹,

Jiang²,

Han³

et al. 2018

Oncotarget

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ABSTRACTmicroRNAs play important regulatory roles in hematologic malignancies, and dysregulation of circulating miRNAs serves as diagnostic, prognostic and predictive biomarkers in many diseases. The correlation of plasma miRNA profiles with the progression of chronic myeloid leukemia (CML) has not been investigated. We have applied microarrays to identify differentially expressed miRNAs, followed by qRT-PCR to validate candidate miRNAs from four sample pools including chronic phase (CP), accelerated phase(AP), blast crisis(BC) and healthy control. Clustering analyses revealed varying phase-specific patterns of plasma miRNA expression during CML progression. Different phases of CML showed differential expression profiles between sample pools during the progression. The functional annotation tool, DAVID, found that putative targets of dysregulated miRNAs in different phases of diease are involved in several important signaling pathways. Gradually decreased expression levels of miR-451a were validated in CML patients from the CP to AP and BC; when CML patients achieved major molecular response (MMR), miR-451a expression was increased and restored to normal range. These data provide an important resource for studies on CML progression and allow a better understanding of the fundamental differences in plasma miRNA expression profiles among the different phases of CML.

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Expression of microRNA-451 in normal and thalassemic erythropoiesis

Cited by 47 publications

References 24 publications

hsa-miR-503 Is Downregulated in β Thalassemia Major

hsa-miR-503 Is Downregulated in β Thalassemia Major

The Influence of Polymorphisms in Disease Severity in β-Thalassemia

WITHDRAWN: Expression profiles and biological implications of plasma miRNAs associated with chronic myeloid leukemia phases

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