Expression of metastasis-associated protein 3 in human brain glioma related to tumor prognosis

Abstract

Glioma represents a disparate group of tumors characterized by high invasion ability, and therefore it is of clinical significance to identify molecular markers and therapeutic targets for better clinical management. Previously, metastasis-associated protein family (MTA) is considered to promote tumor cell invasion and metastasis of human malignancies. Recently, the newly identified MTA3 has been shown to play conflicting roles in human malignancies, while the expression pattern and potential clinical significance of MTA3 in human glioma have not been addressed yet. In the present study, we investigated the protein expression of MTA3 by immunohistochemistry assay and analyzed its association with glioma prognosis in 186 cases of patients. Results showed that MTA3 expression was decreased in glioma compared with that in normal brain (P < 0.05). In addition, tumors with high MTA3 expression were more likely to be of low WHO grade (P = 0.005) and reserve of body function (P = 0.014). Survival analysis showed that decreased MTA3 expression was independently associated with unfavorable overall survival of patients (P < 0.001). These results provide the first evidence that MTA3 expression was decreased in human glioma and negatively associated with prognosis of patients, suggesting that MTA3 may play a tumor suppressor role in glioma.

Long non‐coding RNA HCG11 suppresses the growth of glioma by cooperating with the miR‐4425/MTA3 axis

“…MTA3 presented the highest fold change in normal and glioma tissues (Figure B). MTA3 has been reported to be a tumor inhibitor in several tumors, including glioma . Thus, we chose MTA3 for subsequent experiments.…”

Metastasis-associated protein 3 in colorectal cancer determines tumor recurrence and prognosis

“…Moreover, limited publications indicated that MTA3 might play conflicting roles compared with the other two MTA members [22]. The expression level of MTA3 was found to be down-regulated in human brain glioma and closely correlated to clinicopathologic characteristics and outcome of patients [23]. While in human brain glioma cell lines, knockdown of MTA2 expression was found to could significantly suppress tumor cell growth, migration and invasion [24].…”

Corepressor metastasis-associated protein 3 modulates epithelial-to-mesenchymal transition and metastasis

“…MTA3 is underexpressed in glioma [99], ovarian cancer [100], and endometrial cancer [101]. MTA3 expression was reported to be associated with differentiation [13], cancer progression [14], and overall survival rates [14, 99].…”

“…MTA3 expression was reported to be associated with differentiation [13], cancer progression [14], and overall survival rates [14, 99]. Given that the malignancies such as glioma, ovarian cancer, and endometrial cancer have nature of invasive and migration, further studies are required to elucidate how MTA3 regulates the EMT and metastasis in these cancers.…”