Expression of metalloproteinases in pigmented villonodular synovitis

Darling, Jama M.; Glimcher, Laurie H.; Shortkroff, Sonya; Albano, Benjamin; Gravallese, Ellen M.

doi:10.1016/0046-8177(94)90254-2

Cited by 23 publications

(13 citation statements)

References 29 publications

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“…The expression of both MMP-1 and MMP-3 has been examined in pigmented villonodular synovitis, which is considered to be a closely related entity of GCTTS. Interestingly, MMP-1 and MMP-3 were predominantly detectable in MC of the synovial membrane, whereas GC were not noted to express these proteinases in significant amounts (13). It is thus possible that cathepsin B participates in bone erosion in pigmented villonodular synovitis and GCTTS by either matrix degradation or activation of MMP as well.…”

Section: Discussionmentioning

confidence: 98%

“…A variety of matrix-degrading enzymes has been suggested to contribute to bone and cartilage damage in other synovial lesions, such as rheumatoid arthritis and pigmented villonodular synovitis. Besides matrix metalloproteinases (MMP), the cysteine proteinases cathepsin B and the recently found Type K are especially involved in the destruction of the extracellular matrix (13)(14)(15)(16)(17). Cathepsin B is able to degrade different types of collagen and proteoglycans as well as the bone matrix protein osteocalcin (16,17).…”

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confidence: 99%

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Expression of Cysteine Proteinases Cathepsins B and K and of Cysteine Proteinase Inhibitor Cystatin C in Giant Cell Tumor of Tendon Sheath

Hansen

Gäumann

et al. 2001

Modern Pathology

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The expression of cysteine proteinases cathepsins B and K and of the endogenous inhibitor of cysteine proteinases, cystatin C, was investigated in tissue specimens of patients with giant cell tumor of tendon sheath (GCTTS). Expression of both enzymes was examined by immunohistochemistry in tissue specimens of 14 patients with GCTTS. Applying double-labeling techniques, the coexpression of cathepsin B and its major endogenous inhibitor cystatin C was additionally studied. Cells expressing the respective proteins were further characterized with the macrophage markers HAM56 and anti-CD68 (clone PG-M1). Cathepsin B could be detected in numerous HAM56-positive mononuclear cells (MC), but only in very few giant cells (GC). In contrast, cathepsin K was predominantly identified in GC that were also strongly immunoreactive for cystatin C and CD68. Coexpression of cathepsin B and cystatin C occurred only in a few MC. The strong expression of both cathepsin B and K suggests that in GCTTS, bone erosion might be mediated not only by pressure of the proliferative tissue, but also by matrix-degrading cysteine proteinases. Because previous studies showed that osteoclasts express high levels of CD68, cathepsin K, and cystatin C but not of cathepsin B, our study contributes to the view that GC of GCTTS and osteoclasts are closely associated.

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Section: Discussionmentioning

confidence: 98%

mentioning

confidence: 99%

Expression of Cysteine Proteinases Cathepsins B and K and of Cysteine Proteinase Inhibitor Cystatin C in Giant Cell Tumor of Tendon Sheath

Hansen

Gäumann

et al. 2001

Modern Pathology

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“…On pense que l'augmentation de la pression articulaire pourrait favoriser les érosions osseuses donnant lieu à des formations kystiques, les parois de ces kystes se briseraient ensuite laissant place à une invasion du tissu synovial. Une seconde hypothèse prétend que les cellules bordant la synoviale sont responsables d'une augmentation de production d'ARN messager pour la synthèse de collagénase de métallo-protéine et de stromalyzine [6]. Suivant ces auteurs, il est probable que ces enzymes conduisent à une atteinte osseuse et cartilagineuse comme dans la polyarthrite rhumatoïde.…”

Section: Discussionunclassified

Synovite villonodulaire hémopigmentée du poignet envahissant l'os. À propos d'un cas

Andaloussi

Fnini

Bendriss

et al. 2006

Chirurgie de la Main

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“…All slides were hybridized at 45°C overnight under previously described conditions, using "S-labeled RNA probes ( 5 X 10' counts per minuteIlS-pI volume of hybridization mix added to each slide). Washes, dehydration, and autoradiography were as previously described (23), and slides were stored at 4°C in light-proof containers. An initial short exposure of pre-and posttreatment slides was performed, and the final exposure time was chosen to optimize grain density for image analysis.…”

Section: Methodsmentioning

confidence: 99%

N‐[4‐hydroxyphenyl] retinamide in rheumatoid arthritis: A pilot study

Gravallese

Händel

Coblyn

et al. 1996

Arthritis & Rheumatism

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Objective. To evaluate the efficacy and tolerability of N‐[4 hydroxyphenyl] retinamide (4‐HPR), a synthetic retinoid, in the treatment of rheumatoid arthritis (RA). Methods. An uncontrolled, open clinical trial with synovial biopsy pre‐ and postmedication to evaluate the clinical effects of 4‐HPR as well as its effects on metalloproteinase gene expression. Results. Twelve patients with severe, longstanding RA were enrolled in this study. Six patients withdrew before study completion, 2 because of drug toxicity, 2 because of a flare of RA, and 2 because of intercurrent medical problems. No patient met predetermined Paulus criteria for treatment response, and there was no improvement in the laboratory parameters, except for a modest decrease in C‐reactive protein. No decrease in messenger RNA for the metalloproteinases collagenase and stromelysin was seen in the 2 patients in whom paired synovial biopsies were obtained. Conclusion. No beneficial clinical effect was observed with the retinoid 4‐HPR in the treatment of severe, longstanding RA at the 300 mg/day dosage studied. The use of higher dosages is precluded by the observed toxicities. The effect of this drug in patients with early or mild disease was not studied. Although this particular retinoid was not effective in this pilot study, the use of other retinoids in RA should still be considered.

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Expression of metalloproteinases in pigmented villonodular synovitis

Cited by 23 publications

References 29 publications

Expression of Cysteine Proteinases Cathepsins B and K and of Cysteine Proteinase Inhibitor Cystatin C in Giant Cell Tumor of Tendon Sheath

Expression of Cysteine Proteinases Cathepsins B and K and of Cysteine Proteinase Inhibitor Cystatin C in Giant Cell Tumor of Tendon Sheath

Synovite villonodulaire hémopigmentée du poignet envahissant l'os. À propos d'un cas

N‐[4‐hydroxyphenyl] retinamide in rheumatoid arthritis: A pilot study

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