Expression of Matrix Metalloproteinases in Intraductal Papillary Mucinous Neoplasm of the Pancreas

Abstract

Background/Aim: Intraductal papillary mucinous neoplasm (IPMN) has a variety of histological and morphological appearances. Matrix metalloproteinases (MMPs) have been considered to be associated with tumor progression or poor prognosis. The aim of this study was to elucidate the molecular basis of IPMN variation in different types of lesions. Materials and Methods: The expression of MMP-1,2,7,9 in 51 cases of IPMN were investigated. The MMP score was calculated as the sum of the score of staining distribution and the score of the intensity staining. Results: MMP scores were correlated with histological grade, histological subtype, and type of invasion. MMP high expression groups (MMP score ≥5) had worse prognosis than low-expression groups. Conclusion: MMP expression varied between different types of IPMN, a result supporting differences in molecular basis of malignancies. These considerations may be helpful for optimal management or treatment according to various types of IPMN.

Is There a Trojan Horse to Aggressive Pancreatic Cancer Biology? A Review of the Trypsin-PAR2 Axis to Proliferation, Early Invasion, and Metastasis

“…45 Also, expression of several MMPs (MMP-1, -2, -7, and -9) were investigated in a set of IPMNs (known precursors to PDAC) and the MMP expression correlated with the histological grade, type, and invasion of these IPMNs, with higher expression score of MMPs conferring a poorer prognosis. 46 Proteinase-Activated Receptor 2 as an Important Co-Player Proteases can also communicate directly to cells by activation of a unique group of transmembrane G-proteincoupled receptors known as protease-activated receptors (PAR). There are four mammalian PARs (PAR-1, -2, -3, and -4), but most interesting in the current setting is PAR-2.…”