Expression of Manganese Superoxide Dismutase mRNA in the Rat Adrenal Cortex is Associated with the Occurrence of Mitochondrial Vesicular Cristae.

Okada, Takao; Sasaki, Junzo; Nomura, Takako; Watanabe, Sadahiro; Matsuura, Junko; Kanda, Shigeto; Sato, Eisuke F.

doi:10.1267/ahc.28.389

Cited by 3 publications

(4 citation statements)

References 20 publications

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“…We have earlier shown the involvement of SOD in luteal steroidogenesis and its induction by LH (3). The role of SOD in steroidogenesis has been corroborated by other workers (18,9,10). hCG/eCG have both been shown to cause expression of SOD (19,11).…”

Section: Discussionsupporting

confidence: 73%

Activity profile of placental superoxide‐superoxide dismutase system in pregnant mice and its possible relation with placental steroidogenesis

et al. 1997

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Placenta in mouse generate increasing quantities of superoxide dismutase from day 13 of pregnancy until parturition. This is associated with a concomitant reduction in the activity of superoxide radical. This findings points to the steroidogenic control of the later half of pregnancy by the placental axis. Parturition is associated with an abrupt spurt in superoxide radical. This is a novel finding and could be a consequence of the estrogen surge at labour. It is suggested that this abrupt increase in superoxide radical level at parturition may remould the placental membrane fluid at the point of its attachment with uterine membranes so as to facilitate the separation of placenta from uterus.

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Section: Discussionsupporting

confidence: 73%

Activity profile of placental superoxide‐superoxide dismutase system in pregnant mice and its possible relation with placental steroidogenesis

et al. 1997

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“…It is intriguing that Okada et al (1995) have associated MnSOD with the tubulovesicular conformation of mitochondria characteristic of the zonae fasciculata/reticularis in the rat, and we have argued that this morphology is associated, not only with the production of corticosterone, but also with the generally high level of steroidogenesis in these cells (Vinson 2004). All this suggests that MnSOD has a highly specific function in the regulation of fasciculata function and glucocorticoid secretion by corticotrophin.…”

Section: Discussionmentioning

confidence: 83%

“…Mitochondrial MnSOD activity in glomerulosa fractions was not significantly affected by any of the treatments. Yet another interpretation arises from the work of Okada et al (1995), who have postulated a key role for peroxidase-ascorbate reaction in the generation of progesterone from pregnenolone. The hydrogen peroxide generated by MnSOD in the mitochondrial matrix is believed to pass through the mitochondrial membrane and may be used to oxidise ascorbic acid to ascorbyl radicals.…”

Section: Discussionmentioning

confidence: 99%

“…It is possible that such a mechanism may account for the relationship between plasma corticosterone and MnSOD, but it does not suggest why aldosterone output should be so independent of glomerulosa fraction MnSOD, which in any case is never high (Figs 5,6). It is unclear why Okada et al (1995) apparently rejected the concept that MnSOD is associated with NADP reduction, and hence mitochondrial hydroxylation.…”

Section: Discussionmentioning

confidence: 99%

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Manganese superoxide dismutase activity in the rat adrenal

Raza¹,

Okamoto²,

Takemori³

et al. 2005

Journal of Endocrinology

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In the light of studies suggesting that transcription of the gene coding for manganese superoxide dismutase (MnSOD) is induced by ACTH in the rat adrenal gland, northern blot analysis was used to determine its mRNA distribution. It was found that mRNA coding for MnSOD is primarily present in the inner zones of the rat adrenal cortex, and not the glomerulosa. To investigate the functional relationships between MnSOD activity and expression and adrenocortical function, adrenals and blood were taken from animals pretreated with corticotrophin or betamethasone (Betnesol), or subjected to a low-sodium diet. MnSOD activity in inner zone mitochondrial fractions was enhanced by corticotrophin and by a low-sodium diet, but suppressed by betamethasone. Apparent cytosolic MnSOD activity, total cytosolic MnSOD and CuZnMn-SOD, and glomerulosa mitochondrial MnSOD all were unaffected. Steroid assays showed a clear correlation between circulating corticosterone and inner zone mitochondrial MnSOD, but none between aldosterone and glomerulosa MnSOD.Immunoblot analysis of MnSOD showed two apparent isoforms, at approximately 25 kDa and 75 kDa. There was a partial relationship between expression of the 75 kDa isoform and MnSOD activity, in that it was induced by corticotrophin. However, there was also a slight induction with betamethasone, and a low-sodium diet had no effect. The 25 kDa MnSOD isoform was unaffected by the treatments. The results suggest that MnSOD may have a specific role in the steroidogenic function of the fasciculata/reticularis of the rat adrenal, but not in that of the glomerulosa.

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Expression of Phospholipid Hydroperoxide Glutathione Peroxidase(PHGPx) mRNA in Rat Testes.

Mori

Nomura

Seno

et al. 2001

Acta Histochem. Cytochem

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Expression of Manganese Superoxide Dismutase mRNA in the Rat Adrenal Cortex is Associated with the Occurrence of Mitochondrial Vesicular Cristae.

Cited by 3 publications

References 20 publications

Activity profile of placental superoxide‐superoxide dismutase system in pregnant mice and its possible relation with placental steroidogenesis

Activity profile of placental superoxide‐superoxide dismutase system in pregnant mice and its possible relation with placental steroidogenesis

Manganese superoxide dismutase activity in the rat adrenal

Expression of Phospholipid Hydroperoxide Glutathione Peroxidase(PHGPx) mRNA in Rat Testes.

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