Expression of Malic Enzymes in Sebaceous Lesions

Abstract

Malic enzymes (MEs) are involved in fatty acid biosynthesis and lipid accumulation, and their expression in sebocytes and sebaceous lesions has not been investigated. The aims of this study were to examine ME1 and ME2 expression in normal skin and sebaceous lesions. A total of 68 cases including 5 specimens of normal skin, 12 facial lesions showing sebaceous hyperplasia, 18 sebaceous adenomas, 10 sebaceomas, 13 steatocystomas, and 10 sebaceous carcinomas were examined for the expression of ME1 and ME2. All benign and malignant sebaceous lesions showed ME1 in clear cells and ME2 in nonclear cells, respectively. ME1/ME2 phenotype is seen in basal sebocytes, basal keratinocytes, sweat glands, and outer root sheath cells and hence not specific. This study demonstrates that ME1/ME2 expression phenotype may have a potential to be a valuable marker for sebaceous differentiation. It is necessary to perform large-scale studies including skin tumors with a clear cell morphology that may mimic sebaceous differentiation.

Malic enzyme 2 as a potential therapeutic drug target for cancer

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“…Therefore, MEs are considered crucial for gluconeogenesis, glycolysis, and fatty acid synthesis. In mammalian cells, three isoforms of MEs are present including NADP‐dependent cytosolic isoform of malic enzyme (ME1), NADP(+)‐dependent mitochondrial isoform of malic enzyme (ME2), and NADP(+)‐dependent mitochondrial isoform of malic enzyme (ME3) (Table ). Among these, ME1 and ME2 are predominantly studied.…”

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Integrated transcriptomics, proteomics and metabolomics to identify biomarkers of astragaloside IV against cerebral ischemic injury in rats

“…32,33 Malic enzymes (MEs) have been proposed to be critical for gluconeogenesis, and glycolysis, based on the rationale that MEs are involved in the regulation of redox balance, cellular energy, and molecular biosynthesis by converting the Krebs cycle intermediate malate to pyruvate and NADPH. 34 Malic enzyme (Me2) is one of the isoforms of MEs. Evidence from multiple studies suggests that Me2 plays an important role in cancer cell growth, proliferation, invasion, and survival by regulating multiple signaling pathways.…”