Expression of MACC1 and c-Met in human gastric cancer and its clinical significance

Abstract

BackgroundRecent studies have suggested that the metastasis-associated colon cancer1 (MACC1) gene can promote tumor proliferation, invasion and metastasis through an upregulation of c-Met expression. However, its role in gastric cancer is controversial. Our study investigated expression of MACC1 and c-Met in gastric cancer, as well as correlated this with clinicopathological parameters.MethodsExpressions of MACC1 and c-Met protein in a sample of 98 gastric carcinoma and adjacent nontumorous tissues were detected by immunohistochemistry. Their relationships and correlations with clinicopathological features were analyzed.ResultsThe positive rates of MACC1 and c-Met protein in primary tumors were 61.22% and 59.18%, respectively. A significant correlation was found between expression of MACC1 and c-Met (P<0.05). Expression of the MACC1 protein in gastric cancer tissue was correlated with lymph node metastasis (χ2 = 10.555,P = 0.001), peritoneal metastasis (χ2 = 5.694, P = 0.017), and hepatic metastasis (χ2 = 4.540,P = 0.033), but not with age, gender, tumor size, location, clinical stage or the distant metastases (P>0.05).ConclusionThe positive rate of MACC1 protein expression was related to the protein expression of c-Met. Both had a correlation with the presence of peritoneal metastasis, lymph node metastasis and hepatic metastasis, all of which contribute to a poor prognosis for gastric cancer patients.

RETRACTED: Silence of MACC1 decreases cell migration and invasion in human malignant melanoma through inhibiting the EMT

“…Consistent with our results, downregulation of MACC1 remarkably inhibited cell migration and invasion in gastric cancer (13), glioma (14) and ovarian cancer (15). Previous studies have demonstrated that deregulation of HGF/ c-MET signaling, governed by MACC1 induces various malignant behaviors in cancer (16).…”

MACC1 and HGF are associated with survival in patients with gastric cancer

“…Both HGF and c-Met are associated with progression, metastasis and survival in gastric cancer (22). Previous studies have demonstrated that MACC1, similar with c-Met, is upregulated in hepatocellular carcinoma, and that the mRNA levels of MACC1 and c-Met are significantly associated (23).…”

Clinical significance of MET in gastric cancer

“…Retterspitz reported that MET was overexpressed in 51% (45 of 88) of diffuse type tumors [24] . MET overexpression has been significantly associated with tumor invasion depth [12,13,23] , lymph-node metastasis [12,13,19,20,25,26] , distant metastasis [12,13,25] , tumor stage [12,20,23,26] , and recurrence [14] , although several studies found no relation to any clinicopathological factors [24,27,28] . MET overexpression correlated with liver metastasis only in stage Ⅳ disease [29] .…”

“…MET overexpression correlated with liver metastasis only in stage Ⅳ disease [29] . Some studies showed that MET overexpression was an independent prognostic factor that was significantly related to poor survival [12][13][14]19,20,25,26,[30][31][32] . In one study, p-MET was detected in 59% (72 of 121) of GC tumors and was significantly associated with lymph-node metastasis, disease stage, and outcomes [20] .…”