Expression of LXR‑β, ABCA1 and ABCG1 in human triple‑negative breast cancer tissues

Pan, Hailing; Zheng, Yue; Pan, Qi; Chen, Honglei; Chen, Fuchun; Wu, Jie; Di, Dingxin

doi:10.3892/or.2019.7279

Cited by 26 publications

(30 citation statements)

References 30 publications

(41 reference statements)

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“…This signature includes four overexpressed lipid metabolism-related genes [ 310 ]. ABCA1 has been proposed as a specific marker of triple-negative breast cancer (TNBC) since its expression was higher in TNBC tissues compared with noncancerous mammary tissues [ 311 ]. Additionally, high-level expression of ABCA1 in primary tumors of serous ovarian cancer was associated with reduced survival of the patients and enhanced tumor cell growth and migration [ 312 ].…”

Section: Abca1 In Cancermentioning

confidence: 99%

The Role of the ATP-Binding Cassette A1 (ABCA1) in Human Disease

Jacobo-Albavera

Domínguez‐Pérez

Medina-Leyte

et al. 2021

IJMS

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Cholesterol homeostasis is essential in normal physiology of all cells. One of several proteins involved in cholesterol homeostasis is the ATP-binding cassette transporter A1 (ABCA1), a transmembrane protein widely expressed in many tissues. One of its main functions is the efflux of intracellular free cholesterol and phospholipids across the plasma membrane to combine with apolipoproteins, mainly apolipoprotein A-I (Apo A-I), forming nascent high-density lipoprotein-cholesterol (HDL-C) particles, the first step of reverse cholesterol transport (RCT). In addition, ABCA1 regulates cholesterol and phospholipid content in the plasma membrane affecting lipid rafts, microparticle (MP) formation and cell signaling. Thus, it is not surprising that impaired ABCA1 function and altered cholesterol homeostasis may affect many different organs and is involved in the pathophysiology of a broad array of diseases. This review describes evidence obtained from animal models, human studies and genetic variation explaining how ABCA1 is involved in dyslipidemia, coronary heart disease (CHD), type 2 diabetes (T2D), thrombosis, neurological disorders, age-related macular degeneration (AMD), glaucoma, viral infections and in cancer progression.

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Section: Abca1 In Cancermentioning

confidence: 99%

The Role of the ATP-Binding Cassette A1 (ABCA1) in Human Disease

Jacobo-Albavera

Domínguez‐Pérez

Medina-Leyte

et al. 2021

IJMS

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“…A high expression of ABCA1 in TNBC tissues was significantly associated with histological grade. However, no significant differences were identified between the expression levels of LXR-β and ABCG1 in both mammary tissues [62]. A mass spectrometry-based label-free quantification followed by functional annotation was performed to investigate the most significant deregulated proteins among various tissues from patients diagnosed with invasive ductal carcinoma: the primary breast tumor, axillary metastatic lymph nodes, and the corresponding contralateral and adjacent non-tumor tissues..…”

Section: Ohc Oxysterols Lxrs and Breast Cancermentioning

confidence: 99%

Cholesterol, Oxysterols and LXRs in Breast Cancer Pathophysiology

Nazih

Bard

2020

IJMS

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Breast cancer is the most frequent cancer among women. In 2018, it is estimated that 627,000 women died from breast cancer. This is approximately 15% of all cancer deaths among women (WHO 2018). Breast cancer is a multifactorial chronic disease. While important progress has been made to treat patients, many questions regarding aspects of this disease relating to carcinogenesis are still open. During carcinogenesis, cells exhibit cholesterol homeostasis deregulation. This results in an accumulation of intracellular cholesterol, which is required to sustain their high growth rate. Cholesterol efflux and influx are two metabolic pathways that are necessary to prevent cholesterol accumulation in the cells. Liver X receptors (LXRs) are nuclear receptors that, upon activation, induce the expression of ABC transporters, responsible for promoting cholesterol efflux, and the expression of IDOL (inducible degrader of low-density lipoprotein receptor), in charge of reducing cholesterol influx. Oxysterols, oxygenated derivatives of cholesterol formed through different pathways, have been discovered as LXR-specific ligands. Some oxysterols are involved in tumor formation while others are considered anti-tumor agents. In the present review, we discuss the involvement of cholesterol, oxysterols and LXRs in breast cancer pathophysiology, with an emphasis on the biological effects of LXR ligands.

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“…ABCA1 has been reported to be upregulated at the mRNA and protein level in triple negative breast cancer [ 91 ] and ovarian cancer [ 92 ], but downregulated in prostate cancer [ 93 ]. Higher ABCA1 levels have been associated with resistance to 5-fluorouracil, paclitaxel, etoposide, carboplatin, and mitoxantrone [ 54 ].…”

Section: Structure Function Expression and Gene Regulation Of Amentioning

confidence: 99%

Aberrant DNA Methylation of ABC Transporters in Cancer

Zappe

Cichna‐Markl

2020

Cells

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ATP-binding cassette (ABC) transporters play a crucial role in multidrug resistance (MDR) of cancers. They function as efflux pumps, resulting in limited effectiveness or even failure of therapy. Increasing evidence suggests that ABC transporters are also involved in tumor initiation, progression, and metastasis. Tumors frequently show multiple genetic and epigenetic abnormalities, including changes in histone modification and DNA methylation. Alterations in the DNA methylation status of ABC transporters have been reported for a variety of cancer types. In this review, we outline the current knowledge of DNA methylation of ABC transporters in cancer. We give a brief introduction to structure, function, and gene regulation of ABC transporters that have already been investigated for their DNA methylation status in cancer. After giving an overview of the applied methodologies and the CpGs analyzed, we summarize and discuss the findings on aberrant DNA methylation of ABC transporters by cancer types. We conclude our review with the discussion of the potential to target aberrant DNA methylation of ABC transporters for cancer therapy.

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Expression of LXR‑β, ABCA1 and ABCG1 in human triple‑negative breast cancer tissues

Cited by 26 publications

References 30 publications

The Role of the ATP-Binding Cassette A1 (ABCA1) in Human Disease

The Role of the ATP-Binding Cassette A1 (ABCA1) in Human Disease

Cholesterol, Oxysterols and LXRs in Breast Cancer Pathophysiology

Aberrant DNA Methylation of ABC Transporters in Cancer

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