Expression of long noncoding RNAs in breast cancer in relation to reproductive factors and tumor characteristics

Ghafouri‐Fard, Soudeh; Taheri, Mohammad; Oskooei, Vahid Kholghi

doi:10.1002/jcb.28671

Cited by 8 publications

(7 citation statements)

References 22 publications

(49 reference statements)

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“…Dissimilarities was observed in previous study, compared with our results, which might be the uniformity of definition and isolation techniques for CSCs [46]. In addition, the origins of CSCs within a cancer have not been clarified, oncogenic transformation from progenitor cells or normal tissue stem cells might be one of possible mechanisms [14], which might be accompanied with abnormal nucleic acid metabolism, such as DNA methylation [47] or RNA expression [48]. Moreover, one of the most important issues about cancer therapy is that increasing evidence has shown chemotherapeutic resistance in cancers, which is considered partially due to the existence of CSCs [14].…”

Section: Discussionsupporting

confidence: 53%

Untargeted LC–MS/MS analysis reveals metabolomics feature of osteosarcoma stem cell response to methotrexate

et al. 2020

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Background: Cancer stem cell (CSC) is identified in osteosarcoma (OS) and considered resistant to chemotherapeutic agents. However, the mechanism of osteosarcoma stem cell (OSC) resistant to chemotherapy remains debatable and vague, and the metabolomics feature of OSC is not clarified. Materials and methods: OSC was isolated by using sphere forming assay and identified. Untargeted LC-MS/MS analysis was performed to reveal the metabolomics feature of OSC and underlying mechanisms of OSC resistant to methotrexate (MTX). Results: OSC was efficiently isolated and identified from human OS 143B and MG63 cell lines with enhanced chemoresistance to MTX. The untargeted LC-MS analysis revealed that OSC showed differential metabolites and perturbed signaling pathways, mainly involved in metabolisms of fatty acid, amino acid, carbohydrate metabolism and nucleic acid. After treated with MTX, metabolomics feature of OSC was mainly involved metabolisms of amino acid, fatty acid, energy and nucleic acid. Moreover, compared with their parental OS cells response to MTX, the differential metabolites and perturbed signaling pathways were mainly involved in metabolism of amino acid, fatty acid and nucleic acid. What's more, Rap1 signaling pathway and Ras signaling pathway were involved in OS cells and their SCs response to MTX. Conclusion: Sphere-forming assay was able to efficiently isolate OSC from human OS cell lines and the untargeted LC-MS/MS analysis was suggested a sufficient methodology to investigate metabolomics features of OS cells and OSCs. Moreover, the metabolomics features of OSCs response to MTX might reveal a further understanding of chemotherapeutic resistance in OS.

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Section: Discussionsupporting

confidence: 53%

Untargeted LC–MS/MS analysis reveals metabolomics feature of osteosarcoma stem cell response to methotrexate

et al. 2020

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“…Opa-interacting protein 5 antisense transcript 1 (OIP5-AS1) is a long intergenic noncoding RNA located in human chromosome at 15q15.1 and transcribed in the antisense of OIP5 gene (14)(15)(16). Also, OIP5-AS1 has been known to regulate the progression of multiple malignancies, such as breast cancer (17,18), malignant melanoma (19), osteosarcoma (20,21), lung adenocarcinoma (22)(23)(24), bladder cancer (25), and colorectal cancer (26). However, the role of OIP5-AS1 in CC is still obscure.…”

Section: Introductionmentioning

confidence: 99%

lncRNA OIP5-AS1 targets ROCK1 to promote cell proliferation and inhibit cell apoptosis through a mechanism involving miR-143-3p in cervical cancer

Song

Wang

Pan

et al. 2020

Braz J Med Biol Res

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Opa-interacting protein 5 antisense transcript 1 (OIP5-AS1) is one kind of cytoplasmic long non-coding RNA (lncRNA), which has been demonstrated to play a critical function in multiple cancers. However, the detailed mechanism of OIP5-AS1 in the regulation of cervical cancer progression is still obscure. Here, we demonstrated that lncRNA OIP5-AS1 was upregulated in cervical cancer and was correlated with poor prognosis by bioinformatics studies. OIP5-AS1 depletion inhibited cell proliferation and promoted cell apoptosis in cervical cancer cells. Furthermore, we clarified that ROCK1 was the downstream effector of OIP5-AS1 and OIP5-AS1 acted as a molecular sponge of miR-143-3p. Finally, we verified that OIP5-AS1 exerted its function in the regulation of cervical cancer progression via interacting with miR-143-3p to regulate ROCK1 expression. Our study revealed novel mechanisms about how lncRNA OIP5-AS1 executed its function in cervical cancer and thus provided potential therapeutic targets for the disease.

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“…Aberrantly expressed lncRNAs may exert tumour-suppressive and oncogenic functions by regulating tumour-related mRNAs upon anticancer therapy. 29,30 Herein, the current study explored the role of the LINC00160/C/EBPβ/TFF3 axis in BC, and the key findings indicated that LINC00160 mediated the paclitaxel resistance in MCF-7 cells and doxorubicin resistance in BT474 cells.…”

Section: Discussionmentioning

confidence: 98%

“…quired to provide favourable treatment outcomes with less adverse effects. Aberrantly expressed lncRNAs may exert tumour-suppressive and oncogenic functions by regulating tumour-related mRNAs upon anticancer therapy 29,30. Herein, the current study explored the role of the LINC00160/C/EBPβ/TFF3 axis in BC, and the key findings indicated that LINC00160 mediated the paclitaxel resistance in MCF-7 cells and doxorubicin resistance in BT474 cells.LncRNAs have the potential to offer diagnostic, prognostic and predictive functions in BC, with up-regulated (NEAT1)12 or down-regulated (MAGI2-AS3)31 expression patterns during tumour progression 32.…”

mentioning

confidence: 92%

LINC00160 mediated paclitaxel‐And doxorubicin‐resistance in breast cancer cells by regulating TFF3 via transcription factor C/EBPβ

Zhou

et al. 2020

J Cellular Molecular Medi

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Expression of long noncoding RNAs in breast cancer in relation to reproductive factors and tumor characteristics

Cited by 8 publications

References 22 publications

Untargeted LC–MS/MS analysis reveals metabolomics feature of osteosarcoma stem cell response to methotrexate

Untargeted LC–MS/MS analysis reveals metabolomics feature of osteosarcoma stem cell response to methotrexate

lncRNA OIP5-AS1 targets ROCK1 to promote cell proliferation and inhibit cell apoptosis through a mechanism involving miR-143-3p in cervical cancer

LINC00160 mediated paclitaxel‐And doxorubicin‐resistance in breast cancer cells by regulating TFF3 via transcription factor C/EBPβ

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