Expression of long noncoding RNA NBAT1 is associated with the outcome of patients with non-small cell lung cancer

Abstract

SUMMARY OBJECTIVE Long noncoding RNA neuroblastoma-associated transcript 1 (NBAT1) has been reported to be involved in cancer progression. However, the clinical significance of NBAT1 in non-small cell lung cancer (NSCLC) is still unclear. Our present research aimed to explore whether NBAT1 serves as a biomarker for NSCLC prognosis. METHODS The expression of NBAT1 was examined by RT-PCR in tissue samples of 162 NSCLC patients and was compared with the adjacent non-tumor lung specimens. Then the association between NBAT1 expression and clinical-pathological parameters was further evaluated. Survival analysis was performed using the Kaplan-Meier method. The prognostic significance of NBAT1 expression in NSCLC patients was explored by the use of univariate and multivariate analyses. RESULTS NBAT1 expression was prominently decreased in NSCLC tissues compared with matched normal lung specimens (p < 0.01). Moreover, survival analyses indicated that patients with low expression displayed dramatically decreased 5-year overall survival (p = 0.008). CONCLUSIONS NBAT1 expression might contribute to tumor progression and poor prognosis of NSCLC and might be a new therapeutic target in NSCLC.

The Value of Dysregulated LncRNAs on Clinicopathology and Survival in Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis

“…A total of 48 eligible studies involving 5,211 patients diagnosed with NSCLC were included in this meta-analysis. Of these studies, 38 studies ( Hou et al, 2014 ; Deng et al, 2015 ; Lin et al, 2015 ; Wang et al, 2015 ; Cui et al, 2016 ; Wan et al, 2016 ; Xue et al, 2016 ; Zhang et al, 2016 ; Li and Jiang, 2017 ; Liu et al, 2017 ; Zhang et al, 2017 ; Song and ZHang, 2018 ; Tian and Feng, 2018 ; Xie et al, 2018 ; Yin et al, 2018 ; Liu et al, 2019 ; An et al, 2019 ; Han et al, 2019 ; Jin et al, 2019 ; Navarro et al, 2019 ; Li et al, 2019 ; Tang et al, 2019 ; Wang et al, 2019 ; Xie et al, 2019 ; Xu et al, 2019 ; Yang et al, 2019 ; Yao et al, 2019 ; Castellano et al, 2020 ; Chen J et al, 2020 ; Chen Z et al, 2020 ; Fang et al, 2020 ; Hua et al, 2020 ; Ma et al, 2020 ; Wang L et al, 2020 ; Wang D et al, 2020 ; Xie and Hu, 2020 ; Fan et al, 2021 ; Wang et al, 2021a ) with 4,126 patients reported high expression of lncRNAs and 10 ( Han et al, 2013 ; Sun et al, 2014 ; Xie et al, 2014 ; Wang Z et al, 2016 ; Gao et al, 2018 ; Yu et al, 2019 ; Zhou et al, 2019 ; Wang Y et al, 2020 ; Wang et al, 2021b ; Zhang et al, 2021 ) with 1,085 patients reported low expression of lncRNAs. These studies were published between 2013 and 2020, among which, 46 studies were conducted in China ( Hou et al, 2014 ; Deng et al, 2015 ; Lin et al, 2015 ; Wang et al, 2015 ; Cui et al, 2016 ;…”

“…These studies were published between 2013 and 2020, among which, 46 studies were conducted in China ( Hou et al, 2014 ; Deng et al, 2015 ; Lin et al, 2015 ; Wang et al, 2015 ; Cui et al, 2016 ; Wan et al, 2016 ; Xue et al, 2016 ; Zhang et al, 2016 ; Li and Jiang, 2017 ; Liu et al, 2017 ; Zhang et al, 2017 ; Song and ZHang, 2018 ; Tian and Feng, 2018 ; Xie et al, 2018 ; Yin et al, 2018 ; Liu et al, 2019 ; An et al, 2019 ; Han et al, 2019 ; Jin et al, 2019 ; Li et al, 2019 ; Tang et al, 2019 ; Wang et al, 2019 ; Xie et al, 2019 ; Xu et al, 2019 ; Yang et al, 2019 ; Yao et al, 2019 ; Han et al, 2013 ; Sun et al, 2014 ; Xie et al, 2014 ; Wang et al, 2016b ; Gao et al, 2018 ; Yu et al, 2019 ; Zhou et al, 2019 ; Zhang S et al, 2020 ; Chen J et al, 2020 ; Wang Y et al, 2020 ; Chen Z et al, 2020 ; Wang D et al, 2020 ; Fang et al, 2020 ; Hua et al, 2020 ; Ma et al, 2020 ; Xie and Hu, 2020 ; Wang et al, 2021a ; Wang et al, 2021b ; Fan et al, 2021 ; Zhang et al, 2021 ) and two studies in Spain ( Navarro et al, 2019 ; Castellano et al, 2020 ). There were 44 studies of NSCLC ( Hou et al, 2014 ; Deng et al, 2015 ; Lin et al, 2015 ; Wang et al, 2015 ; Cui et al, 2016 ; Wan et al, 2016 ; Xue et al, 2016 ; Zhang et al, 2016 ;…”

“…All of the studies applied the quantitative real-time polymerase chain reaction (qRT-PCR) to measure the lncRNA expression level. There were more than 100 samples in 24 studies ( Deng et al, 2015 ; Cui et al, 2016 ; Wan et al, 2016 ; Li and Jiang, 2017 ; Liu et al, 2017 ; Zhang et al, 2017 ; Tian and Feng, 2018 ; Xie et al, 2018 ; An et al, 2019 ; Tang et al, 2019 ; Xie et al, 2019 ; Xu et al, 2019 ; Yang et al, 2019 ; Chen J et al, 2020 ; Fang et al, 2020 ; Ma et al, 2020 ; Xie and Hu, 2020 ; Sun et al, 2014 ; Xie et al, 2014 ; Wang Z et al, 2016 ; Gao et al, 2018 ; Wang Y et al, 2020 ; Wang et al, 2021b ; Zhang et al, 2021 ) and less than 100 samples in 24 studies ( Hou et al, 2014 ; Lin et al, 2015 ; Wang et al, 2015 ; Xue et al, 2016 ; Zhang et al, 2016 ; Song and ZHang, 2018 ; Yin et al, 2018 ; Liu et al, 2019 ; Han et al, 2019 ; Jin et al, 2019 ; Navarro et al, 2019 ; Li et al, 2019 ; Wang et al, 2019 ; Yao et al, 2019 ; Castellano et al, 2020 ; Chen Z et al, 2020 ; Hua et al, 2020 ; Wang L et al, 2020 ; Wang D et al, 2020 ; Fan et al, 2021 ; Wang et al, 2021a ; Han et al, 2013 ; Yu et al, 2019 ; Zhou et al, 2019 ). Overall survival (OS) ( Han et al, 2013 ; Hou et al, 2014 ; Sun et al, 2014 ; Xie et al, 2014 ; Deng et al, 2015 ; Lin et al, 2015 ; Wang et al, 2015 ...…”

An Overview of Long Non-Coding (lnc)RNAs in Neuroblastoma

“…NBAT-1, the lncRNA neuroblastoma-associated transcript-1, has been identified as an independent prognostic marker for the clinical outcome in patients with NB [46,47], non-small cell lung cancer (NSCLC) [48] and in oesophageal cancer [49], and studies also proposed its association with hepatocellular carcinoma (HCC) [50], renal carcinoma [51,52], lung [53] and breast cancer [54], tumorigenesis, proliferation, migration and invasion [47]. Loss of NBAT-1 has been observed in NB cells, and in particular, a significantly lower expression has been highlighted in HR-NB.…”

Comment on “Expression of long noncoding RNA NBAT1 is associated with the outcome of patients with non-small cell lung cancer”

“…We read the article "Expression of long noncoding RNA NBAT1 is associated with the outcome of patients with nonsmall cell lung cancer" by Wang et al 1 with great interest. Although long noncoding RNA neuroblastoma-associated transcript one expression might contribute to tumor progression and poor prognosis of non-small cell lung cancer (NSCLC), some points should be raised from our point of view.…”