Expression of long non-coding RNA LINC00973 is consistently increased upon treatment of colon cancer cells with different chemotherapeutic drugs

Zinovieva, Olga L.; Grineva, E. N.; Prokofjeva, M. M.; Карпов, Д. С.; Zheltukhin, Andrei O.; Krasnov, George S.; Snezhkina, Anastasiya V.; Kudryavtseva, Anna V.; Chumakov, P. M.; Mashkova, T. D.; Prassolov, Vladimir; Лисицын, Н. А.

doi:10.1016/j.biochi.2018.05.021

Cited by 30 publications

(17 citation statements)

References 25 publications

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“…Using RNA-Seq, RT-qPCR, bioinformatics, and murine tumor xenograft models, one group reported that the expression of five lincRNAs, including LINC00973, LINC00941, CASC19, CCAT1 and BCAR4, are consistently altered in HT-29 and HCT-116 cells after treatments with 5-FU, oxaliplatin and irinotecan both in vitro and in vivo. Among these five lincRNAs, LINC00973 is most strongly upregulated in colon cancer cells treated with 5-FU, oxaliplatin, and irinotecan [51]. This report demonstrated that lncRNAs may participate in drug resistance in colon cancer.…”

Section: Lncrnas Regulate Drug Resistancementioning

confidence: 57%

Long noncoding RNAs: functions and mechanisms in colon cancer

2020

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Evidence indicates that long non-coding RNAs (lncRNAs) play a crucial role in the carcinogenesis and progression of a wide variety of human malignancies including colon cancer. In this review, we describe the functions and mechanisms of lncRNAs involved in colon oncogenesis, such as HOTAIR, PVT1, H19, MALAT1, SNHG1, SNHG7, SNHG15, TUG1, XIST, ROR and ZEB1-AS1. We summarize the roles of lncRNAs in regulating cell proliferation, cell apoptotic death, the cell cycle, cell migrative and invasive ability, epithelial-mesenchymal transition (EMT), cancer stem cells and drug resistance in colon cancer. In addition, we briefly highlight the functions of circRNAs in colon tumorigenesis and progression, including circPPP1R12A, circPIP5K1A, circCTIC1, circ_0001313, circRNA_104916 and circRNA-ACAP2. This review provides the rationale for anticancer therapy via modulation of lncRNAs and circular RNAs (circRNAs) in colon carcinoma.

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Section: Lncrnas Regulate Drug Resistancementioning

confidence: 57%

Long noncoding RNAs: functions and mechanisms in colon cancer

2020

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“…In hepatocellular carcinoma, high expression of LINC00941 significantly promoted EMT and malignant capacity tissues and correlated with poor prognosis (Yan et al, 2017). LINC00941 was differentially expressed in TGF-β1-activated A549 cells compared with those in normal controls (Liu H. et al, 2017) and was up-regulated upon treatment of colon cancer cells with chemotherapeutic drugs (Zinovieva et al, 2018). In GC, LINC00941 is up-regulated in tumor tissues (Luo et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Long Non-coding RNA LINC00941 as a Potential Biomarker Promotes the Proliferation and Metastasis of Gastric Cancer

Liu

Zhang

et al. 2019

Front. Genet.

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Gastric cancer (GC) is a considerable global health burden. Accumulating evidence suggests that long non-coding RNAs (lncRNAs) are aberrantly expressed in many cancers and play important roles in GC. However, only a few lncRNAs have been functionally characterized. In this study, we identified that long intergenic non-protein coding RNA 941 (LINC00941) is a potential biomarker for diagnosis and prognosis from the cancer genome atlas (TCGA), and we found that the expression of LINC00941 is associated with tumor depth and distant metastasis in GC. Furthermore, functional enrichment analysis of LINC00941 co-expression network demonstrated that LINC00941 might be an essential regulator of tumor metastasis and cancer cell proliferation. To validate our findings, we utilized the loss-of-function analysis to reveal the biological function of LINC00941 in GC cells. Loss-of-function analysis revealed that silence of LINC00941 inhibits GC cells proliferation, migration, and invasion in vitro and modulates tumor growth in vivo. Our findings confirmed that LINC00941 plays an important oncogenic function in GC and may serve as a potential biomarker for diagnosis and prognosis of GC.

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“…Some of the ten lung cancer survival-related lncRNAs echoes previous studies on cancer. A recent investigation reported that LINC00973 was involved in chemotherapy resistance of colon cancer [19]. CTD-2357A8.3 was identified as a biomarker for predicting survival in esophageal cancer [20].…”

Section: Discussionmentioning

confidence: 99%

Analysis of Survival-Related lncRNA Landscape Identifies A Role for LINC01537 in Energy Metabolism and Lung Cancer Progression

Gong

Yang

Wang

et al. 2019

IJMS

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Many long non-coding RNAs (lncRNAs) have emerged as good biomarkers and potential therapeutic targets for various cancers. We aimed to get a detailed understanding of the lncRNA landscape that is associated with lung cancer survival. A comparative analysis between our RNA sequencing (RNA-seq) data and TCGA datasets was conducted to reveal lncRNAs with significant correlations with lung cancer survival and then the association of the most promising lncRNA was validated in a cohort of 243 lung cancer patients. Comparing RNA-seq data with TCGA ones, 84 dysregulated lncRNAs were identified in lung cancer tissues, among which 10 lncRNAs were significantly associated with lung cancer survival. LINC01537 was the most significant one (p = 2.95 × 10−6). Validation analysis confirmed the downregulation of LINC01537 in lung cancer. LINC01537 was observed to inhibit tumor growth and metastasis. It also increased cellular sensitivity to nilotinib. PDE2A (phosphodiesterase 2A) was further identified to be a target of LINC01537 and it was seen that LINC01537 promoted PDE2A expression via RNA–RNA interaction to stabilize PDE2A mRNA and thus echoed effects of PDE2A on energy metabolism including both Warburg effect and mitochondrial respiration. Other regulators of tumor energy metabolism were also affected by LINC01537. These results elucidate a suppressed role of LINC01537 in lung cancer development involving tumor metabolic reprogramming, and we believe that it might be a biomarker for cancer survival prediction and therapy.

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Expression of long non-coding RNA LINC00973 is consistently increased upon treatment of colon cancer cells with different chemotherapeutic drugs

Cited by 30 publications

References 25 publications

Long noncoding RNAs: functions and mechanisms in colon cancer

Long noncoding RNAs: functions and mechanisms in colon cancer

Long Non-coding RNA LINC00941 as a Potential Biomarker Promotes the Proliferation and Metastasis of Gastric Cancer

Analysis of Survival-Related lncRNA Landscape Identifies A Role for LINC01537 in Energy Metabolism and Lung Cancer Progression

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