Expression of lncRNAs AK058003 and APOC1P1 in breast cancer patients

Rajabi, Ali; Saber, Aly; Abdolahi, Sepehr; Maydanchi, Melika; Tayefeh-Gholami, Samaneh; Safaralizadeh, Reza

doi:10.1080/15257770.2022.2075556

Cited by 4 publications

(4 citation statements)

References 21 publications

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“…Similar to these results ,another research observed that the expression levels of AK058003 gene was not significant relative to hormone receptors including ER, PR and HER2 [18] .…”

Section: Attar Et Al (2021) Rajabi and Mozdaranisupporting

confidence: 73%

“…(2022)& He and Wang (2015) showed that there was a significant association as regards lymph node involvement [18,25] .…”

Section: Similar To Our Result Attar Et Al (2021)mentioning

confidence: 96%

“…Furthermore, Rajabi et al ( 2022) [18] . reported that LncRNA-AK058003 expression was shown to promote breast cancer proliferation [18] , invasion and metastasis by regulating SNCG expression of LncRNA-AK058003 was significantly higher in the tumour as compared to control group .…”

Section: Figure (2): Receiver Operating Characteristic Curve For Lncr...mentioning

confidence: 99%

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LncRNAsAk058003 Overexpression in the Blood of a Group of Breast Cancer Egyptian females

Mohammed,

Abdel Aziz,

Ibrahim

et al. 2024

Egyptian Journal of Medical Research

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__________________________________________________Background: Breast cancer (BC) is one of commonest malignancies among females. Many factors play a role in breast cancer like age at menarche and menopause, breastfeeding, physical activity, and dietary habit. However, genetics still play a significant role as a key player in breast cancer occurrence.Objectives: This research aimed to assess the gene expression of Lnc RNAs AK058003 and to analyze their dysregulation with clinical features in Egyptian BC patients. Methods: A case-control research was done with 27 breast cancer patients ages 30 to 80 years old at

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“…Similar to these results ,another research observed that the expression levels of AK058003 gene was not significant relative to hormone receptors including ER, PR and HER2 [18] .…”

Section: Attar Et Al (2021) Rajabi and Mozdaranisupporting

confidence: 73%

“…(2022)& He and Wang (2015) showed that there was a significant association as regards lymph node involvement [18,25] .…”

Section: Similar To Our Result Attar Et Al (2021)mentioning

confidence: 96%

See 1 more Smart Citation

LncRNAsAk058003 Overexpression in the Blood of a Group of Breast Cancer Egyptian females

Mohammed,

Abdel Aziz,

Ibrahim

et al. 2024

Egyptian Journal of Medical Research

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“…Han et al ( 14 ) identified that lncRNA APOC1P1 can inhibit the inflammatory response in malignant bile duct cell carcinoma. In another study, lncRNA APOC1P1 was found to be overexpressed in breast cancer ( 15 ) and was confirmed to regulate the pathogenesis of cholangiocarcinoma ( 16 ). Considering the relationship between cholangiocarcinoma and HCC, we hypothesized whether lncRNA APOC1P1 plays certain mechanism in HCC development and progression.…”

Section: Introductionmentioning

confidence: 93%

Suppression of hepatocellular carcinoma progression by long noncoding RNA apolipoprotein C1 pseudogene via the regulation of the microRNA-106b-PTEN axis

Qian,

Chen,

Chen

et al. 2023

Transl Cancer Res

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Background Numerous researches have reported that long noncoding RNAs (lncRNAs) participate in tumor development and progression. LncRNA apolipoprotein C-I pseudogene 1 ( APOC1P1 ), a pseudogene located in 19q13.2 between apolipoprotein C-I and apolipoprotein C-IV, is involved in a variety of diseases. However, the role of lncRNA APOC1P1 in hepatocellular carcinoma (HCC) remains unknown. Methods Quantitative polymerase chain reaction (qPCR) was performed to examine the expression of APOC1P1 , miR-106b, and PTEN (phosphatase and TENsin homolog deleted on chromosome 10) in HCC tissues, adjacent normal tissues, and specific cell lines (LO2, Bel-7407, HCCLM3, MHCC-97H, Hep G2, and Huh-7). Upregulation of APOC1P1 and downregulation of miR-106b were conducted via application of vector transfection and microRNA (miRNA) inhibitor. Bioinformatics analysis and luciferase reporter assay were used to verify the binding sites of APOC1P1 , miR-106b, and PTEN. Cell proliferation and invasion were determined with Cell Counting Kit-8 (CCK-8) and Transwell experiments. Subcellular location analysis was used to determine the distribution of APOC1P1 in cells, and Western blotting was used to detect the expression of PTEN. Results It was found that the expressions of APOC1P1 and PTEN were downregulated, while that of miR-106b was upregulated in HCC tissues and cells. Subcellular location analysis showed that APOC1P1 was localized in cytoplasm and competitively bound to miR-106b. APOC1P1 overexpression and miR-106b inhibition suppressed HCC cell proliferation and invasion. qPCR indicated the negative correlation between APOC1P1 expression and miR-106b expression in HCC tissues and a positive correlation between APOC1P1 and PTEN. Conclusions Our findings suggested that the lncRNA APOC1P1 inhibits HCC progression by competitively binding to miR-106b, leading to elevated PTEN expression, inhibiting cell proliferation and invasion in HCC cells. These results provide new insights into the diagnosis and therapy of HCC.

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Up-regulation of BOK-AS1, FAM215A and FEZF1-AS1 lncRNAs and their potency as moderate diagnostic biomarkers in gastric cancer

Moazzen,

Rajabi,

Safaralizadeh

2023

Pathology - Research and Practice

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Expression of lncRNAs AK058003 and APOC1P1 in breast cancer patients

Cited by 4 publications

References 21 publications

LncRNAsAk058003 Overexpression in the Blood of a Group of Breast Cancer Egyptian females

LncRNAsAk058003 Overexpression in the Blood of a Group of Breast Cancer Egyptian females

Suppression of hepatocellular carcinoma progression by long noncoding RNA apolipoprotein C1 pseudogene via the regulation of the microRNA-106b-PTEN axis

Up-regulation of BOK-AS1, FAM215A and FEZF1-AS1 lncRNAs and their potency as moderate diagnostic biomarkers in gastric cancer

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