Expression of lncRNA APF in Peripheral Blood of Patients with Acute Myocardial Infarction Caused by Coronary Heart Disease and its Clinical Significance

Abstract

Coronary heart disease (CHD) is the leading cause of death from cardiovascular disease. This study investigated the expression and clinical significance of long noncoding RNA (lncRNA) autophagy promoting factor (APF) in peripheral blood of patients with acute myocardial infarction (AMI) caused by CHD. Patients with angina pectoris (AP) (n = 80) and AMI (n = 96) and other patients (n = 60) with precordial discomfort but no CHD were included. The serum levels of lncRNA APF, MIAT, MALAT1, H19, CHAST, CDR1AS, miR-188-3 p, and cardiac troponin I (cTnI)/creatine kinase (CK)/creatine kinase isozymes (CK-MB) were detected using reverse transcription-quantitative polymerase chain reaction or enzyme-linked immunosorbent assay. Patients with AMI were divided into high/low expression groups based on the median level of APF, and the clinical baseline indicators of patients with AMI were compared. The correlation between lncRNA APF and cTnI/CK/ CK-MB/miR-188-3p was analyzed using Pearson analysis, and the clinical value of lncRNA APF was evaluated using the receiver operating characteristic curve. The levels of lncRNA APF, MIAT, MALAT1, H19, CHAST, and CDR1AS in patients with AMI were increased, whereas there were no differences in patients with AP. The APF levels in patients with AMI were higher than MIAT, MALAT1, and CHAST, whereas there were no differences between APF and H19 and CDR1AS. In patients with AMI, the high level of lncRNA APF was correlated with the history of smoking/drinking. Moreover, lncRNA APF was positively correlated with cTnI/CK/ CK-MB levels and negatively correlated with miR-188-3p. LncRNA APF has high diagnostic efficacy for AMI. Overall, lncRNA APF is highly expressed in patients with AMI caused by CHD and has high diagnostic efficacy for AMI.

LncRNA-MALAT1: A Key Participant in the Occurrence and Development of Cancer

“…The results revealed that lncRNA-MALAT1 expression was upregulated in AML patients with sepsis. The overall survival rate was significantly lower in the group with high lncRNA-MALAT1 expression levels than in the group with low expression levels [53]. Artesunate, a derivative of artemisinin, could regulate the expression of apoptosis-related proteins such as Bcl-2, Bax, caspase-3, and PTEN via the PI3K/AKT signaling pathway and promote apoptosis in human AML cells.…”

MIAT LncRNA: A multifunctional key player in non-oncological pathological conditions

“…Similar findings were also reported by Wang et al, where MIAT was found to be more highly expressed in MI patients, although its expression was not positively correlated with cardiac biomarkers [ 200 ]. Additionally, a more recent clinical study conducted on a Chinese population also observed higher MIAT expression in MI patients compared to normal individuals [ 201 ]. These collective findings provide valuable insights into the potential utility of MIAT as a diagnostic biomarker in the context of MI.…”