Expression of leptin and its long-form receptor in the marginal cutaneous tissues of diabetic foot ulcers

Cao, Ying; Gao, Fang; Li, Chen-Zhong; Xue, Yan

doi:10.1007/s00592-012-0428-8

Cited by 10 publications

(3 citation statements)

References 36 publications

(42 reference statements)

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“…Leptin protein expression was significantly higher in the DU and NDU than in the NC group ( p < 0.001), whereas OB-RL (leptin receptor-long form) mRNA and protein expressions were significantly lower in the DU group and significantly higher in the NDU group. Diabetic foot ulcer duration was negatively correlated with OB-RL protein expression [ 60 ].…”

Section: Resultsmentioning

confidence: 99%

Wound Healing Impairment in Type 2 Diabetes Model of Leptin-Deficient Mice—A Mechanistic Systematic Review

Stachura

Khanna

Krysiak

et al. 2022

IJMS

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Type II diabetes mellitus (T2DM) is one of the most prevalent diseases in the world, associated with diabetic foot ulcers and impaired wound healing. There is an ongoing need for interventions effective in treating these two problems. Pre-clinical studies in this field rely on adequate animal models. However, producing such a model is near-impossible given the complex and multifactorial pathogenesis of T2DM. A leptin-deficient murine model was developed in 1959 and relies on either dysfunctional leptin (ob/ob) or a leptin receptor (db/db). Though monogenic, this model has been used in hundreds of studies, including diabetic wound healing research. In this study, we systematically summarize data from over one hundred studies, which described the mechanisms underlying wound healing impairment in this model. We briefly review the wound healing dynamics, growth factors’ dysregulation, angiogenesis, inflammation, the function of leptin and insulin, the role of advanced glycation end-products, extracellular matrix abnormalities, stem cells’ dysregulation, and the role of non-coding RNAs. Some studies investigated novel chronic diabetes wound models, based on a leptin-deficient murine model, which was also described. We also discussed the interventions studied in vivo, which passed into human clinical trials. It is our hope that this review will help plan future research.

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Section: Resultsmentioning

confidence: 99%

Wound Healing Impairment in Type 2 Diabetes Model of Leptin-Deficient Mice—A Mechanistic Systematic Review

Stachura

Khanna

Krysiak

et al. 2022

IJMS

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“…It is also a general pharmacological fact that whenever the first messenger is decreased then its receptor is increased (upregulation-downregulation). Moreover, Cao et al 20 reported that decreased Ob-R expression might be related to the negative feedback resulting from high leptin protein concentrations.…”

Section: Discussionmentioning

confidence: 99%

Leptin receptor (Ob-R) mRNA expression and serum leptin concentration in patients with colorectal and metastatic colorectal cancer

Erkasap

Özkurt

Erkasap

et al. 2013

Braz J Med Biol Res

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The objective of the present study was to investigate the effect of leptin on the progression of colorectal carcinoma to metastatic disease by analyzing the serum leptin concentration and Ob-R gene expression in colon cancer tissues. Tissue samples were obtained from 31 patients who underwent surgical resection for colon (18 cases) and metastatic colon (13 cases) cancer. Serum leptin concentration was determined by an enzyme-linked immunosorbent assay (ELISA) and Ob-R mRNA expression by real-time polymerase chain reaction (RT-PCR) for both groups. ELISA data were analyzed by the Student t-test and RT-PCR data were analyzed by the Mann-Whitney U-test. RT-PCR results demonstrated that mRNA expression of Ob-R in human metastatic colorectal cancer was higher than in local colorectal cancer tissues. On the other hand, mean serum leptin concentration was significantly higher in local colorectal cancer patients compared to patients with metastatic colorectal cancer. The results of the present study suggest a role for leptin in the progression of colon cancer to metastatic disease without weight loss. In other words, significantly increased Ob-R mRNA expression and decreased serum leptin concentration in patients with metastatic colon cancer indicate that sensitization to leptin activity may be a major indicator of metastasis to the colon tissue and the determination of leptin concentration and leptin gene expression may be used to aid the diagnosis.

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“…Topical administration of leptin significantly promoted wound healing, increased angiogenesis in dermis and activated proliferation and differentiation of epidermal keratinocytes [75]. Leptin protein expression was significantly higher in both diabetic and non-diabetic foot ulcers [76].…”

Section: Fish Oil and Leptin And Adiponectinmentioning

confidence: 99%

Positive Impact of Fish Oil on Diabetic and Hypercholestrolemic Skin Disorders

2015

J Nutr Health

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The integumentary system is soft a highly organized structure of epidermis and dermis, which is tightly conjugated with each other. The epidermis represents the outer covering and is formed of epidermal layers, Langerhan, Merkel cell, melanocytes and immune cells travestied by hair follicles. Sweat glands are infiltrated throughout the integumentary layers, including fibroblast, and mast cells. Hair follicles with complex structure, characterized with their complicated structures and their internal structure contains immune cells during differentiation and possesses sebaceous glands for sebum productionthe antibacterial components. A calcium and potassium ion in close association with lipid and cholesterol represents the main elements in epidermal permeability. Keratinocytes represent the elementary part for cholesterol and lipid formation. Cholesterol overload led to altered cell structure, hair follicle formation, integrity of blood vessels and dermal collagen. It caused deformation of hair follicles and disrupted epidermal structures and keratinocyte formation leading to impairing keratinization. Fish oil represents one of the main food additives having biomedical importance. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) represent their main components and play a great role in promoting permeability, growth and differentiation of the stratum corneum and inhibition of proinflammatory cytokines (tumor necrosis factor-α, interferon-γ, and interleukin-12 which improve the diabetic and hypercholesterolemic complications

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Expression of leptin and its long-form receptor in the marginal cutaneous tissues of diabetic foot ulcers

Cited by 10 publications

References 36 publications

Wound Healing Impairment in Type 2 Diabetes Model of Leptin-Deficient Mice—A Mechanistic Systematic Review

Wound Healing Impairment in Type 2 Diabetes Model of Leptin-Deficient Mice—A Mechanistic Systematic Review

Leptin receptor (Ob-R) mRNA expression and serum leptin concentration in patients with colorectal and metastatic colorectal cancer

Positive Impact of Fish Oil on Diabetic and Hypercholestrolemic Skin Disorders

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