Expression of LC3B and FIP200/Atg17 in brain metastases of breast cancer

Abstract

These results support assessments of precision medicine-guided targeting of autophagy in treatment of brain metastases in breast cancer patients.

Autophagic Degradation of NBR1 Restricts Metastatic Outgrowth during Mammary Tumor Progression

“…The paradox between functional outcomes of autophagy during primary and metastatic tumor growth highlights the exquisitely stage-specific role of autophagy during metastatic progression in breast cancer. Previous studies have observed increased LC3 puncta in human breast, melanoma, and hepatocellular carcinoma metastases compared to primary tumors, suggesting a differential requirement for autophagy in human primary tumors versus metastases (Hashemi-Sadraei et al, 2018;Lazova et al, 2012;Peng et al, 2013). Our results lend experimental support for this notion and provide additional evidence that autophagic impairment promotes metastasis through aberrant accumulation of NBR1.…”

Autophagy-mediated tumor cell survival and progression of breast cancer metastasis to the brain

“…nih.gov/geo/) analysis has identified a set of eight autophagy-related genes (BCL2, BIRC5, EIF4EBP1, ERO1L, FOS, GAPDH, ITPR1 and VEGFA) associated with a prognostic signature of BC patients [67]. One recent study suggested that LC3B and ATG17 elevated expression in brain metastases are correlated with significantly shorter survival time in TNBC patients [68]. These results are in line with a strategy to target autophagy in the treatment of brain metastases in BC patients.…”

NUPR1 promotes the proliferation and migration of breast cancer cells by activating TFE3 transcription to induce autophagy

“…Autophagy-related genes are found to be associated with breast cancer based on gene expression pro les(8). The overexpression of LC3 and ATG17, the autophagyassociated proteins, in breast cancer tissues is signi cantly correlated with the high metastasis rate of patients (9). Moreover, the overexpression of ATG10, the key protein of autophagy vesicle formation, in breast cancer tissue suggests that the patients have poor prognosis and the possibility of lymph node metastasis (10).…”