Expression of LAIR-1 (CD305) on Human Blood Monocytes as a Marker of Hepatic Cirrhosis Progression

Martínez‐Esparza, María; Ruiz–Alcaraz, Antonio J.; Carmona‐Martínez, Violeta; Fernández-Fernández, María Dolores; Antón, Gonzalo; Muñoz-Tornero, María; Lencina, Miriam; Pagán, Inmaculada; Peña, J. de la; García‐Peñarrubia, Pilar

doi:10.1155/2019/2974753

Cited by 13 publications

(17 citation statements)

References 42 publications

(55 reference statements)

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“…Since an exacerbated inflammatory response might be potentially harmful, the control of the pro-inflammatory mechanisms by an anti-inflammatory counterbalance is an important protective process against further enhancement of inflammation (50,51). Our different in vitro and in vivo models indicate that inflammation leads to an upregulation of LAIR-1, as observed here in monocytes from sepsis patients, but also on circulating monocytes in acute myocardial infarction, rheumatoid arthritis and liver cirrhosis (52)(53)(54). The upregulation of LAIR-1 during inflammation, for instance mediated by TLR or IFN signals, will facilitate its inhibitory signals.…”

Section: Discussionmentioning

confidence: 54%

Leukocyte Associated Immunoglobulin Like Receptor 1 Regulation and Function on Monocytes and Dendritic Cells During Inflammation

et al. 2020

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Inhibitory receptors are crucial immune regulators and are essential to prevent exacerbated responses, thus contributing to immune homeostasis. Leukocyte associated immunoglobulin like receptor 1 (LAIR-1) is an immune inhibitory receptor which has collagen and collagen domain containing proteins as ligands. LAIR-1 is broadly expressed on immune cells and has a large availability of ligands in both circulation and tissues, implicating a need for tight regulation of this interaction. In the current study, we sought to examine the regulation and function of LAIR-1 on monocyte, dendritic cell (DC) and macrophage subtypes, using different in vitro models. We found that LAIR-1 is highly expressed on intermediate monocytes as well as on plasmacytoid DCs. LAIR-1 is also expressed on skin immune cells, mainly on tissue CD14 + cells, macrophages and CD1c + DCs. In vitro, monocyte and type-2 conventional DC stimulation leads to LAIR-1 upregulation, which may reflect the importance of LAIR-1 as negative regulator under inflammatory conditions. Indeed, we demonstrate that LAIR-1 ligation on monocytes inhibits toll like receptor (TLR)4 and Interferon (IFN)-α-induced signals. Furthermore, LAIR-1 is downregulated on GM-CSF and IFN-γ monocyte-derived macrophages and monocyte-derived DCs. In addition, LAIR-1 triggering during monocyte derived-DC differentiation results in significant phenotypic changes, as well as a different response to TLR4 and IFN-α stimulation. This indicates a role for LAIR-1 in skewing DC function, which impacts the cytokine expression profile of these cells. In conclusion, we demonstrate that LAIR-1 is consistently upregulated on monocytes and DC during the inflammatory phase of the immune response and tends to restore its expression during the resolution phase. Under inflammatory conditions, LAIR-1 has an inhibitory function, pointing toward to a potential intervention opportunity targeting LAIR-1 in inflammatory conditions.

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Section: Discussionmentioning

confidence: 54%

Leukocyte Associated Immunoglobulin Like Receptor 1 Regulation and Function on Monocytes and Dendritic Cells During Inflammation

et al. 2020

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“…Olde Nordkamp et al (47) found that SP-D binds the leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1), a receptor expressed on most immune cells, including monocytes, and macrophages (76, 77) (Figure 2). SP-D inhibits reactive oxygen species (ROS) production through binding between SP-D collagen domains and LAIR-1 (47).…”

Section: In Vitro Studies Of Sp-d-mediated Cellular Effectsmentioning

confidence: 99%

The Dual Role of Surfactant Protein-D in Vascular Inflammation and Development of Cardiovascular Disease

2019

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Cardiovascular disease (CVD) is responsible for 31% of all global deaths. Atherosclerosis is the major cause of cardiovascular disease and is a chronic inflammatory disorder in the arteries. Atherosclerosis is characterized by the accumulation of cholesterol, extracellular matrix, and immune cells in the vascular wall. Recently, the collectin surfactant protein-D (SP-D), an important regulator of the pulmonary immune response, was found to be expressed in the vasculature. Several in vitro studies have examined the role of SP-D in the vascular inflammation leading to atherosclerosis. These studies show that SP-D plays a dual role in the development of atherosclerosis. In general, SP-D shows anti-inflammatory properties, and dampens local inflammation in the vessel, as well as systemic inflammation. However, SP-D can also exert a pro-inflammatory role, as it stimulates C-C chemokine receptor 2 inflammatory blood monocytes to secrete tumor necrosis-factor α and increases secretion of interferon-γ from natural killer cells. In vivo studies examining the role of SP-D in the development of atherosclerosis agree that SP-D plays a proatherogenic role, with SP-D knockout mice having smaller atherosclerotic plaque areas, which might be caused by a decreased systemic inflammation. Clinical studies examining the association between SP-D and cardiovascular disease have reported a positive association between circulatory SP-D level, carotid intima-media thickness, and coronary artery calcification. Other studies have found that circulatory SP-D is correlated with increased risk of both total and cardiovascular disease mortality. Both in vitro, in vivo, and clinical studies examining the relationship between SP-D and CVDs will be discussed in this review.

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“…reported that the cross-linking of LAIR-1 with its ligands inhibited the differentiation and activation of B cells induced by B cell receptor cross-linking. 35 However, Liang et al. demonstrated that adaptive immune responses predominated in mild chronic forms of psoriasis such as PsV, while innate and auto-inflammatory responses dominated in acute severe forms such as pustular psoriasis.…”

Section: Discussionmentioning

confidence: 99%

“…This cross-linking is responsible for the inhibition of inflammatory type I IFN production by monocytes. 35 Type I IFN play an indispensable role in initiating psoriasis through enhancing the development of monocyte-derived DC (moDC), which contributes to Th1 and Th17 differentiation and keratinocyte proliferation. Th1 and Th17 interact with monocytes and instruct monocytes to differentiate into Th1- and Th17-promoting moDCs, leading to the formation of more specialised moDC subsets.…”

Section: Discussionmentioning

confidence: 99%

Immunoregulatory complement receptor-1 and leukocyte-associated Ig-like receptor-1 expression on leukocytes inPsoriasis vulgaris

et al. 2020

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Psoriasis vulgaris (PsV) is an immune-mediated inflammatory disorder with devastating psychosocial consequences. Expression of immunoregulator molecules on leukocytes in PsV remains unclear. Leukocyte-associated Ig-like receptor-1 (LAIR-1) and complement receptor-1 (CR-1) are immunoregulator receptors reported to bind complement component 1q involved in phagocytosis. We aimed to explore if altered leukocyte expression of LAIR-1 and CR-1 is associated with PsV. This case–control study included 36 PsV patients and 36 healthy controls. Neutrophils, monocytes and B and T cells were examined by flow cytometry for LAIR-1 and CR-1 mean fluorescence intensity (MFI) and positive cell percentage. Comparison between both groups revealed a significant decrease in LAIR-1 MFI on neutrophils and T cells ( P < 0.001 and P = 0.003, respectively). CR-1 MFI on neutrophils, monocytes and T cells also showed a significant decrease in patients ( P = 0.033, P = 0.001 and P = 0.040, respectively). There was a significant positive correlation of LAIR-1 MFI on neutrophils with CR-1 MFI on neutrophils ( r = 0.503; P = 0.002) and LAIR-1 MFI on monocytes with CR-1 MFI on monocytes ( r = 0.371; P = 0.026). Receiver operating characteristic curves revealed that CR-1 MFI on monocytes had the highest discrimination power to differentiate patients from controls, with 86.1% specificity and 75% sensitivity ( P = 0.001). In conclusion, altered leukocytes expression of LAIR-1 and CR-1 is associated with PsV. Down-regulated CR-1 MFI on monocytes is a promising diagnostic biomarker for PsV.

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Expression of LAIR-1 (CD305) on Human Blood Monocytes as a Marker of Hepatic Cirrhosis Progression

Cited by 13 publications

References 42 publications

Leukocyte Associated Immunoglobulin Like Receptor 1 Regulation and Function on Monocytes and Dendritic Cells During Inflammation

Leukocyte Associated Immunoglobulin Like Receptor 1 Regulation and Function on Monocytes and Dendritic Cells During Inflammation

The Dual Role of Surfactant Protein-D in Vascular Inflammation and Development of Cardiovascular Disease

Immunoregulatory complement receptor-1 and leukocyte-associated Ig-like receptor-1 expression on leukocytes inPsoriasis vulgaris

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