Expression of L1 and PSA during sprouting and regeneration in the adult hippocampal formation

Aubert, Isabelle; Ridet, Jean‐Luc; Schachner, Melitta; Rougon, Geneviève; Gage, Fred H.

doi:10.1002/(sici)1096-9861(19980914)399:1<1::aid-cne1>3.0.co;2-5

Cited by 65 publications

(27 citation statements)

References 65 publications

(82 reference statements)

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“…Interestingly, the most persistent axonal growth occurs in close apposition with a small subpopulation of astrocytes that transiently express PSA-NCAM after lesion (30)(31)(32). Expression of PSA-NCAM is known to block signals transmitted to neuronal cells (33), alter glial cell-based tissue architecture (34), and modulate growth cone behavior (17,35).…”

Section: Resultsmentioning

confidence: 99%

Use of polysialic acid in repair of the central nervous system

Maarouf

Petridis

Rutishauser

2006

Proc. Natl. Acad. Sci. U.S.A.

132

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Polysialic acid (PSA), a large cell-surface carbohydrate that regulates cell interactions, is used during vertebrate development to promote precursor cell migration and axon path-finding. The induction of PSA expression in damaged adult CNS tissues could help them to rebuild by creating conditions permissive for architectural remodeling. This possibility has been explored in two contexts, the regeneration of axons and the recruitment of endogenous neural precursors to a lesion. Glial scars that form at CNS injury sites block axon regeneration. It has been found that transfection of scar astrocytes by a viral vector encoding polysialyltransferase leads to sustained expression of high levels of PSA. With this treatment, a substantial portion of severed corticospinal tract axon processes were able to grow through a spinal injury site. In the studies of precursor cell migration to a cortical lesion, it was found that induced PSA expression in a path extending from the subventricular zone to a lesion near the cortical surface increased recruitment of BrdU͞nestin-positive cells along the path and into the injury site. These displaced precursors were able to differentiate in a regionally appropriate manner. These findings suggest that induced PSA expression can be used as a strategy for promoting tissue repair involving both replacement of cells and rebuilding of neural connections.astrocyte ͉ axon regeneration ͉ brain lesions ͉ plasticity ͉ progenitor migration

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Section: Resultsmentioning

confidence: 99%

Use of polysialic acid in repair of the central nervous system

Maarouf

Petridis

Rutishauser

2006

Proc. Natl. Acad. Sci. U.S.A.

132

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“…L1 is expressed on sprouting primary afferents after dorsal rhizotomy in rats (Runyan et al, 2005) and is implicated as a possible factor for axonal growth following injury to the nervous system (Styren et al, 1995;Aubert et al, 1998;Brook et al, 2000;Roonprapunt et al, 2003;Kubasak et al, 2005;Chen et al, 2007). If L1 is necessary for primary afferent sprouting, we would expect to see little or no sprouting in its absence.…”

Section: L1 Is Not Required For Cgrp-positive Afferent Sproutingmentioning

confidence: 99%

L1 cell adhesion molecule is not required for small-diameter primary afferent sprouting after deafferentation

Runyan

Roy²,

Zhong³

et al. 2007

Neuroscience

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L1 is a cell adhesion molecule associated with axonal outgrowth and fasciculation during spinal cord development and may reiterate its developmental role in adults following injury; L1 is upregulated on certain sprouting and regenerating axons in adults, but it is unclear if L1 expression is necessary for, or contributes to, regrowth of axons. This study asks if L1 is required for small-diameter primary afferents to sprout by conducting unilateral dorsal rhizotomies (6 segments; T10-L2) on both wildtype and L1 mutant mice. First we determined that L1 co-localizes substantially with the peptidergic (calcitonin gene-related peptide; CGRP) but minimally with the nonpeptidergic (isolectin B4; IB4) primary afferents in intact wild-type and L1 mutant mice. However, we encountered a complication using IB4 to identify primary afferents post-rhizotomy; we detected extensive abnormal IB4 expression in the dorsal horn and dorsal columns. Much of this aberrant IB4 labeling is associated with fibrous astrocytes and microglia. Five days after dorsal rhizotomy a large decrease in peptidergic and nonpeptidergic afferents is evident on the deafferented side in both wild-type and L1 mutants. Three months after surgery the peptidergic primary afferents sprouted into the center of the denervated dorsal horn in both wild-type and mutant mice, and quantitative analyses confirmed a sprouting density of similar magnitude in both genotypes. In contrast, we did not detect sprouting in the nonpeptidergic primary afferents in either genotype. These results suggest that the absence of L1 neither diminishes nor enhances sprouting of peptidergic small-diameter primary afferent axons following a dorsal rhizotomy. Keywordscell adhesion molecule; denervated; IB4; CGRP; nociceptors; rhizotomy The cell adhesion molecule L1 (L1 CAM) is an axonal glycoprotein and a member of the immunoglobulin superfamily (Kamiguchi et al., 1997). L1 plays a role in axonal outgrowth, fasciculation, and guidance during spinal cord development (Stallcup et al., 1985;Jessell, 1988;Stoeckli and Landmesser, 1995;Orlino et al., 2000;Tran and Phelps, 2000;Akopians et al., 2003) through homophilic and various heterophilic binding partners such as integrins (αVβ3 and α5β1) and the fibroblast growth factor receptor (Kamiguchi and Lemmon, 1997 Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Lemmon, 1997;Castellani et al., 2000). NIH Public AccessMutations in X-linked L1 in humans cause major developmental errors and result in a group of symptoms that include corpus callosum hypoplasia, spastic paraplegia and hydrocephalus (Fran...

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“…PST is a polysialyltransferase that forms polysialic acid (PSA). In adult rat brains, choline acetyltransferase (ChAT)-positive fibers have been found to express PSA during regeneration in the hippocampal formation and it has been posited that PSA may provide an environment conducive to axonal growth (Aubert et al, 1998). PSA appears to regulate the function of the neural cell adhesion molecule (N-CAM) (e.g.…”

Section: Discussionmentioning

confidence: 99%

Linkage Analyses of Event-Related Potential Slow Wave Phenotypes Recorded in a Working Memory Task

et al. 2005

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Working memory is an essential component of wide-ranging cognitive functions. It is a complex genetic trait probably influenced by numerous genes that individually have only a small influence. These genes may have an amplified influence on phenotypes closer to the gene action. In this study, event-related potential (ERP) phenotypes recorded during a workingmemory task were collected from 656 adolescents from 299 families for whom genotypes were available. Univariate linkage analyses using the MERLIN variance-components method were conducted on slow wave phenotypes recorded at multiple sites while participants were required to remember the location of a target. Suggestive linkage (LOD > 2.2) was found on chromosomes 4, 5, 6, 10, 17, and 20. After correcting for multiple testing, suggestive linkage remained on chromosome 10. Empirical thresholds were computed for the most promising phenotypes. Those on chromosome 10 remained suggestive. A number of genes reported to regulate neural differentiation and function (i.e. NRP1, ANK3, and CHAT) were found under these linkage peaks and may influence the levels of neural activity occurring in individuals participating in a spatial working-memory task.

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Expression of L1 and PSA during sprouting and regeneration in the adult hippocampal formation

Cited by 65 publications

References 65 publications

Use of polysialic acid in repair of the central nervous system

Use of polysialic acid in repair of the central nervous system

L1 cell adhesion molecule is not required for small-diameter primary afferent sprouting after deafferentation

Linkage Analyses of Event-Related Potential Slow Wave Phenotypes Recorded in a Working Memory Task

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