Expression of Ki-67, p53, α-SMA and COX-2 in lichen planus and related lesions: A pilot study

Sanketh, D. S.; Kumari, Karuna; Rao, Roopa S; Haragannavar, Vanishree C; Sarode, Sachin C.; Sarode, Gargi S; Raj, A. Thirumal; Patil, Shankargouda

doi:10.1016/j.jobcr.2018.02.003

Cited by 8 publications

(14 citation statements)

References 20 publications

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“…Nonetheless, many biomarkers expressed in OLP are also overexpressed in OSCC 8 , 20 . The correlation between HSP90 expression, low E-cadherin expression and disease duration for OLP patients observed in this study are partly consistent with previous reports, which suggests that in cases of long disease duration, the risk of genetic changes may be increased 6 , 7 , 20 . In our study, HSP90 expression was more frequently observed in non-erosive OLP, but it was limited to small tissue areas, and this type of OLP is associated with longer disease duration.…”

Section: Discussionsupporting

confidence: 92%

“…The association between the p53 protein and the areas of oral mucosa observed in non-erosive OLP in this study is in line with the observations of Shiva et al 22 , who observed p53 protein expression in non-erosive OLP. The results of this study, which show increased p53 and HSP90 expression and lower E-cadherin expression in OSCC in comparison to OLP are in line with other data indicating that dysfunctions of these proteins may lead to malignant lesions in some cases 6 , 7 , 10 , 11 . The impact of these proteins on the aggressive biological behaviour of OLP lesions is reflected in our data, which shows their increased expression in OSCC, as well as a correlation with worse clinical and pathological features of tumours.…”

Section: Discussionsupporting

confidence: 92%

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Comparison of p53, HSP90, E-cadherin and HPV in oral lichen planus and oral squamous cell carcinoma

Bär

Cierpikowski

Lis-Nawara

et al. 2021

Acta Otorhinolaryngol Ital

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SUMMARY Objective Oral lichen planus (OLP) is a chronic inflammatory disease. There are no markers that can be used to identify the risk of a malignant transformation of OLP to oral squamous cell carcinoma (OSCC). Methods Immunohistochemical staining was performed among 56 patients with OLP and 66 patients with OSCC for p53, HSP90 and E-cadherin expression and presence of HPV16/18. Results Significant differences in p53 and HSP90 expression between OLP and OSCC were found ( p = 0.01 and p = 0.006, respectively). A positive correlation between HSP90 and p53 expression was seen in OLP ( p = 0.017). Univariate analysis identified HSP90 expression and HPV16/18 presence as prognostic factors for overall survival time (OS) ( p < 0.05). In multivariate analysis, only HSP90 expression was an independent prediction factor for shorter OS of OSCC patients ( p = 0.016). Conclusions The present study suggests that cooperation between p53 and HSP90 as well as between HPV16/18 and HSP90 exists in OLP and may affect the biological behaviour of OLP. The observed expression of HSP90 and p53 in OLP and their increase in OSCC suggests that these proteins participate in the malignant transformation of OLP. HSP90 may be a potential independent prognostic biomarker that can predict poor prognosis in OSCC.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Comparison of p53, HSP90, E-cadherin and HPV in oral lichen planus and oral squamous cell carcinoma

Bär

Cierpikowski

Lis-Nawara

et al. 2021

Acta Otorhinolaryngol Ital

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“…Of the 5 included studies ( 5 , 7 - 10 ), two were from India ( 7 , 9 ), one from Canada ( 5 ), one from Australia ( 8 ) and one from Iran ( 10 ). The various diagnosis rendered among these 181 cases included OLD (n=73); OLP with epithelial dysplasia/dysplastic OLP (n=19); oral lichenoid mucositis (OLP or OLL) with epithelial dysplasia (n=73); OLL with dysplasia (n=16).…”

Section: Resultsmentioning

confidence: 99%

“…Oral mucosal lesions presenting with both lichenoid and epithelial dysplastic features are often misdiagnosed. The cause for the misdiagnosis in most of these cases is due to the difficulty in identifying the primary pathology and the lack of universally accepted diagnostic criteria ( 1 - 4 , 7 , 9 ). The present review analyses the varied spectrum of clinicopathological features and diagnoses rendered in original studies investigating oral mucosal lesions with both lichenoid and epithelial dysplastic features.…”

Section: Discussionmentioning

confidence: 99%

The natural history of oral mucosal lesions with both lichenoid and epithelial dysplastic features: a systematic review

Raj¹,

Sarode²,

Sarode³

et al. 2020

Transl Cancer Res TCR

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Background Assessing the natural history of oral mucosal lesions with both lichenoid and epithelial dysplastic features through a systematic review of published literature. Methods Scopus, PubMed, and Web of Science were searched for oral mucosal lesions showing both lichenoid and epithelial dysplastic features from original studies using the keywords “oral lichenoid dysplasia; oral epithelial dysplasia (OED) with lichenoid features; oral lichen planus (OLP) with dysplastic features; oral lichenoid lesions (OLL) with dysplastic features”. Results The search yielded 152 articles (PubMed-84, Scopus-32, Web of Science-36). Among these only 5 studies complied with the selection criteria including the provision of sufficient clinical and histopathological data. Out of these 5 studies, 181 cases were described to exhibit both lichenoid and epithelial dysplastic features. The most common diagnostic criterion employed was of van der Meij et al. Although some studies accepted the presence of epithelial dysplasia in OLL, most rejected the notion of epithelial dysplasia in OLP and designated such lesions as an OLL or oral lichenoid dysplasia. The few studies which accepted the presence of epithelial dysplasia in OLP rendered a diagnosis of OLP with dysplasia. Conclusions The review shows that several diagnoses were used for lesions with similar clinicopathological features and distinct clinicopathological entities were designated similar diagnosis. These diagnostic variations are the primary cause for the discrepancies in the prevalence and malignant transformation rates of these enigmatic entities which in turn often leads to erroneous treatment.

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“…In addition, inflammation is strongly associated with carcinogenesis, including the development and progression of oral cancer [33] [34]. Further, COX-2 expression has been correlated with higher grades of oral epithelial dysplasia and could represent an early event in oral carcinogenesis [35] [36]. Several studies, including that of Arreaza, et al [32], found a higher COX-2 expression in OLP than in OLLs, and Chankong, et al [37] observed a direct correlation between COX-2 expression in OLP and the clinical severity of this pathology.…”

Section: Discussionmentioning

confidence: 99%

Histopathological and Immunohistochemical Study of the Distinction between Oral Lichen Planus and Oral Lichenoid Lesions

Suzuki¹,

Suemitsu²,

Nakayama³

et al. 2021

OJST

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Background: Oral potentially malignant disorders, which include oral lichen planus (OLP), are clinical presentations that carry a risk of development to cancer in the oral cavity. Oral lichenoid lesions (OLLs) are also termed interface/lichenoid mucositis. Malignant transformation of them remains controversial, but distinct clinical and histological criteria for how to differentiate OLP from OLLs have not been developed. Objectives: The purpose of this study was to elucidate findings that can allow histopathological differentiation of OLP and OLLs using histomorphological and immunohistochemical analyses. Materials and Methods: Analyses were performed in 10 cases diagnosed with OLP and 9 cases diagnosed with OLLs. Cytokeratin 19 (CK19), Ki-67 and CD3 were used as primary antibodies to detect basal cells, proliferative activity and T-cell distribution, respectively, and Perlecan and COX-2 to evaluate epithelial intracellular arrangements and interstitial distributions of proteoglycans and enzymes. Results: For CK19, positive cells were significantly found in OLLs at both the prominent area and site adjacent to the lesion comparison with those of OLP's. The number of COX-2 positive cells was significantly higher in spinous and basal layers in OLLs of the prominent area. Additionally, OLLs showed mild to moderate expression for perlecan in the basal to spinous layers and in subepithelial tissue. Conclusion: Almost no basal cells were noted in the prominent area in OLP. COX-2 and perlecan were found in the basal to spinous layers in OLLs.

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Expression of Ki-67, p53, α-SMA and COX-2 in lichen planus and related lesions: A pilot study

Cited by 8 publications

References 20 publications

Comparison of p53, HSP90, E-cadherin and HPV in oral lichen planus and oral squamous cell carcinoma

Comparison of p53, HSP90, E-cadherin and HPV in oral lichen planus and oral squamous cell carcinoma

The natural history of oral mucosal lesions with both lichenoid and epithelial dysplastic features: a systematic review

Histopathological and Immunohistochemical Study of the Distinction between Oral Lichen Planus and Oral Lichenoid Lesions

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