Expression of Ki-67 in odontogenic cysts: A comparative study between odontogenic keratocysts, radicular cysts and dentigerous cysts

Modi, Tapan G; Chalishazar, Monali; Kumar, M. Sathish

doi:10.4103/jomfp.jomfp_94_16

Cited by 18 publications

(12 citation statements)

References 17 publications

(18 reference statements)

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“…As far as current study is concerned strong positive expression was observed same in DC and OKC however in Modi's study it was more in OKC than DC. 19 In another study mean expression of Ki-67 LI was 7.7%, 1.7% and 15.3% for OKC, DC and RC respectively. Out of 4 cases 66.7 % weak positive expression was observed which was focal rather than diffuse, out of 8 cases of DC only one case 12.5% expressed Ki-67 in mild intensity in focal pattern, and only 1/10 cases of RC expressed moderate expression of Ki-67 which was diffuse in nature.…”

Section: Discussionmentioning

confidence: 90%

Clinicopathological Features and Expression of Ki-67 in Odontogenic Keratocyst, Dentigerous Cyst and Radicular Cyst

Rasul

Saif

Jehangir³

et al. 2023

J Islamabad Med Dental Coll

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Background: Biological behaviour of Odontogenic Keratocyst (OKC) is aggressiveness than others Odontogenic Cysts (OCs) like Dentigerous Cyst (DCs) and Periapical Cyst/Residual Cysts (RCs). The aim of the study was to determine clinicopathological features and expression of Ki-67 in Odontogenic Cysts of the oral cavity. Methodology: This cross-sectional study was conducted at de’Montmorency College of Dentistry (DCD from Feb, 2020 to Feb, 2022 after approval from Institutional Review Board (IRB) of DCD. A total 78 cases of OCs were collected from hospitals which are affiliated with the DCD. Routine lab process for Hematoxylin & Eosin and Immunohistochemistry was performed. Data entry and statistical analysis was carried out in SPSS 21. A Chi- square test was applied to observe the association between cyst and Ki-67. P value < 0.05 was taken as statistically significant. Results: Among total 78 cases the mean age was 25.08 ±14.5 years with an age range of 6-70 years. Most OCs (64.1%) were reported in males than females (35.89%). Most OCs were reported in mandible (56.4%. Ki-67 expression in OKC was high 7.7%, low in 76.9% and negative in 15.4%). Most of the DCs and RCs expressed low expression of Ki-67 (84.6% and 76.9% respectively). Conclusion: Most of the odontogenic cysts expressed low expression of Ki-67 while few cases of OKC and DC expressed high expression. Keywords: Dentigerous Cyst, Odontogenic Keratocyst, Immunohistochemistry, Ki-67, Odontogenic Cysts, Periapical Cyst, Radicular Cyst.

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Section: Discussionmentioning

confidence: 90%

Clinicopathological Features and Expression of Ki-67 in Odontogenic Keratocyst, Dentigerous Cyst and Radicular Cyst

Rasul

Saif

Jehangir³

et al. 2023

J Islamabad Med Dental Coll

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“…It has been found that Ki-67 expression in odontogenic keratocyst was more than that of RC 17 , 19 , 20 and dentigerous cyst. 21 This significance was confined to the suprabasal layer than the basal layer. 18 Moreover, Ki-67 expression was more in RC than dentigerous cyst 19 and vice versa.…”

Section: Discussionmentioning

confidence: 99%

“… 6 Ki-67 was already used as a proliferative marker for evaluating the proliferative activity in odontogenic cysts. 17 , 18 , 19 , 20 , 21 The current study evaluated the expression of Ki-67 in the odontogenic epithelium of RC in order to determine the proliferative capacity of the epithelial cells in this cyst and correlate it with P63 expression. It has been concluded that epithelial cells are more important than connective tissue cells when considering the biological behavior of odontogenic lesions.…”

Section: Discussionmentioning

confidence: 99%

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P63 and Ki-67 expression in radicular cyst

Alsaegh

Mahmoud

Varma

et al. 2023

Journal of Oral Biology and Craniofacial Research

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“…By counting 1,000 cells on each slide, it was possible to calculate the percentage of cells that express Ki-67. A qualified pathologist analyzed Ki-67-labeled cell counts using the following formula: Number of IHCpositive cells (KI-67) *100/Total number of cells observed [27].…”

Section: Immunohistochemistry Of Liver Specimensmentioning

confidence: 99%

Anti-angiogenic and anti-proliferative activity of ziziphus leaf extract as a novel potential therapeutic agent for reducing hepatic injury in experimental hamster schistosomiasis

2023

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Background Schistosomiasis is one of the most prevalent helminthic infections worldwide. Praziquantel (PZQ) resistance poses a possible danger to the disease’s ability to be controlled. Little is known about the role of Ziziphus spina-christi leaf extract (ZLE) in the treatment of hepatic schistosomiasis. However, no study has explored ZLE’s anti-angiogenic and anti-proliferative activity as a possible mechanism for reducing hepatic injury in this context. Therefore, this study aimed to evaluate the therapeutic potential of ZLE as an anti-angiogenic, and anti-proliferative agent in hamsters infected with S. mansoni. Methods Fifty hamsters were used and divided into 5 groups (10 hamsters each); noninfected untreated (controls), noninfected treated with ZLE, infected untreated, infected treated with PZQ- and infected treated with ZLE. Anti-angiogenic and anti-fibrotic effects of the drugs were assessed pathologically through the immunohistochemical expression of VEGF, Ki-67, and TGF β1 in liver sections. Some oxidative stress parameters were measured in hepatic homogenates (NO, GSH, GST, and SOD), and serum liver enzymes were also assessed. Results A significant decrease in worm burden, granuloma size, granuloma area, and numbers in the ZLE- and PZQ-treated groups compared to the infected untreated group, and the decrease in granulomas number and tissue egg load was significantly lower in PZQ treated group compared to ZLE treated group (p<0.05). ZLE exhibited significant anti-angiogenic and anti-fibrotic effects on granulomas, illustrated by significantly lower expression of VEGF and TGF-β1 than infected untreated and PZQ-treated groups. ZLE exhibits antiproliferative activity evidenced by a significant reduction of positive Ki-67 hepatocytes percentage compared to the infected untreated group. Moreover, ZLE exhibits potent antioxidant effects evidenced by a significantly lowered NO and conservation of hepatic GSH, GST, and SOD in hepatic homogenates compared to infected untreated and PZQ-treated groups (p<0.05). Conclusion Our results point to ZLE as a promising hepatoprotective therapeutic tool in the treatment of schistosome hepatic fibrosis as it has anti-angiogenic, anti-proliferative, anti-fibrotic, and antioxidant effects in hamsters infected with S. mansoni, providing scientific support for its use in conventional medicine.

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Expression of Ki-67 in odontogenic cysts: A comparative study between odontogenic keratocysts, radicular cysts and dentigerous cysts

Cited by 18 publications

References 17 publications

Clinicopathological Features and Expression of Ki-67 in Odontogenic Keratocyst, Dentigerous Cyst and Radicular Cyst

Clinicopathological Features and Expression of Ki-67 in Odontogenic Keratocyst, Dentigerous Cyst and Radicular Cyst

P63 and Ki-67 expression in radicular cyst

Anti-angiogenic and anti-proliferative activity of ziziphus leaf extract as a novel potential therapeutic agent for reducing hepatic injury in experimental hamster schistosomiasis

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