“…21 TRESK is also expressed in human autonomic nervous system ganglia that may be chronically altered in migraine. 22,23 In addition, due to the coupling of TRESK to the histamine H1 receptor, the channel may reduce neuronal excitability in inflammatory conditions, like during the migraine attack when inflammatory modulators are released into the surrounding tissues. 24,25 Finally, it is of interest to notice that, outside the nervous system, TRESK is abundantly expressed in several organs of the immune system, like the thymus, the spleen, and T lymphocytes, suggesting a role for this channel for neuroimmune interactions.…”