Expression of interleukin‐5 receptors on acute myeloid leukaemia cells: association with immunophenotype and karyotype

Nishii, Kazuhiro; Kita, K; Nadim, Mahumd; Miwa, Hiroshi; Ohoishi, Koushi; Yamaguchi, Motoko; Shirakawa, S

doi:10.1111/j.1365-2141.1995.tb05264.x

Cited by 7 publications

(6 citation statements)

References 9 publications

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“…43 Eosinophilia is one of the characteristic blood pictures of t(8;21)AML, and the in vitro eosinophilic differentiation of the leukemic cells induced by IL-5 was also reported. 16,44 Ema et al 16 reported that IL-5 was able to support the survival of t(8;21)AML cells for more than 4 weeks. Our study indicated that G-CSF and IL-5 were able to promote predominant colony formation of t(8;21)AML cells.…”

Section: Figurementioning

confidence: 99%

Low BCL-2 expression in acute leukemia with t(8;21) chromosomal abnormality

et al. 1999

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Section: Figurementioning

confidence: 99%

Low BCL-2 expression in acute leukemia with t(8;21) chromosomal abnormality

et al. 1999

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“…13 These observations indicate that IL-5 is the major regulator of eosinophil production in vivo, perhaps aided by GM-CSF. It is of relevance therefore that there is expression of IL-5 receptors on leukemias with eosinophil subpopulations 14 and that such cells can respond to IL-5 stimulation by generating eosinophils. 2,3 IL-5 was identified originally as a T lymphocyte product influencing B lymphocyte maturation 15 and stimulating eosinophil colony formation.…”

Section: Introductionmentioning

confidence: 99%

The multi-organ origin of interleukin-5 in the mouse

Ryan

Willson

et al. 2001

Leukemia

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Murine Ba/F3 cells were transfected with cDNA for the ␣-chain of the murine interleukin-5 (IL-5) receptor and cloned lines of these cells were able to proliferate in response to as little as 2.5 pg/ml of IL-5. The bioassay was demonstrated to be specific for IL-5 and was able to measure IL-5 produced in culture by organs from adult C57BL/6 and BALB/c mice. The highest levels of IL-5 were produced by lung tissue but thymus and bladder consistently produced IL-5 and more variable production was observed by the heart, spleen, muscle, bone shaft, uterus and testes. Bone marrow cells produced no detectable IL-5. Observed levels of production of IL-5 were similar when using organs from mice lacking high-affinity receptors for IL-5 and from nu/nu, RAG-1−/− and NOD/SCID mice lacking T lymphocytes. In inflammatory peritoneal exudates induced by the injection of casein plus bacteria, levels of induced IL-5 were higher if the mice lacked high-affinity receptors for IL-5. The data indicate that T lymphocytes are not the dominant cellular source of IL-5 in organ-conditioned media and that local IL-5 production can occur with a wide range of normal murine organs. Leukemia (2001Leukemia ( ) 15, 1248Leukemia ( -1255

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“…[4][5][6][7] Previous reports including ours have demonstrated that t(8;21)AML shows high levels of CD34 and DR expression, with a prevalent positivity for CD19 and CD56 surface markers and a low expression of CD33 and CD7 when compared to AML with normal or other aberrant karyotypes, and eosinophilia is also often observed in t(8;21) AML. [8][9][10][11][12][13][14][15] Cytogenetically, the t(8;21) AML is frequently associated with a loss of the sex chromosome Y in males and inactive X in females; 3 3.4% of the cases are variant translocations. 16 However, the influence of these variant translocations or additional chromosomal abnormalities on the characteristics of t(8;21) AML is still unclear.…”

Section: Introductionmentioning

confidence: 99%

Characteristics of t(8;21) acute myeloid leukemia (AML) with additional chromosomal abnormality: concomitant trisomy 4 may constitute a distinctive subtype of t(8;21) AML

et al. 2003

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and 9 Tokura Hospital, Kyoto, Japan t(8;21)(q22;q22) is the most frequently observed karyotypic abnormality associated with acute myeloid leukemia (AML), especially in FAB M2. Clinically, this type of AML often shows eosinophilia and has a high complete remission rate with conventional chemotherapy. t(8;21) AML is also frequently associated with additional karyotypic aberrations, such as a loss of the sex chromosome; however, it is unclear whether these aberrations change the biological and clinical characteristics of t(8;21) AML. To investigate this issue, 94 patients with t(8;21) AML were categorized according to their additional karyotypic aberrations, which were detected in more than three cases, and then morphologic features, phenotypes, expression of cytokine receptors, and clinical features were compared to t(8;21) AML without other additional aberrant karyotypes. t(8;21) AML with loss of the sex chromosome and abnormality of chromosome 9 were found in 27 cases (29.3%) and 10 cases (10.6%), respectively; however, no differences were observed from the t(8;21) AML without other additional karyotypes in terms of morphological and phenotypic features. There was also no significant difference in the clinical outcome among these three groups. On the other hand, trisomy 4 was found in three cases (3.2%) and these cells showed low expressions of CD19 (P = 0.06) and IL-7 receptor (P = 0.05), and high expressions of CD33 (P = 0.13), CD18 (P = 0.03), and CD56 (P = 0.03) when compared to t(8;21) AML without additional karyotypes. Moreover, all three t(8;21) AML cases with trisomy 4 did not show eosinophilia in their bone marrow and died within 2.4 years. These observations suggest that additional karyotypic aberration, t(8;21) with trisomy 4 is rare, but it may constitute a distinctive subtype of t(8;21) AML.

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Expression of interleukin‐5 receptors on acute myeloid leukaemia cells: association with immunophenotype and karyotype

Cited by 7 publications

References 9 publications

Low BCL-2 expression in acute leukemia with t(8;21) chromosomal abnormality

Low BCL-2 expression in acute leukemia with t(8;21) chromosomal abnormality

The multi-organ origin of interleukin-5 in the mouse

Characteristics of t(8;21) acute myeloid leukemia (AML) with additional chromosomal abnormality: concomitant trisomy 4 may constitute a distinctive subtype of t(8;21) AML

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