Expression of Interleukin-5, Interleukin-8, and Interleukin-10 mRNA in the Osteomeatal Complex in Nasal Polyposis

Chen, Yue-Shih; Arab, Sonja F.; Westhofen, Martin; Lorenzen, Johann

doi:10.1177/194589240501900202

Cited by 23 publications

(24 citation statements)

References 22 publications

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“…Elevated levels of IL-8 have been implicated in the formation of scar in adult skin tissue [11]. Additionally, IL-8 was elevated in chronic rhinosinusitis and nasal polyps [10,21]. Our present study indicated that IL-6 and IL-8 levels were significantly increased in regenerative mucosa, and the levels of IL-6 and IL-8 in the wound had a significant correlation with the level of collagen type I.…”

Section: Discussionsupporting

confidence: 47%

Serial cytokine levels during wound healing in rabbit maxillary sinus mucosa

Sun

Wang

et al. 2009

Acta Oto-Laryngologica

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A large amount of immature spindled collagen deposition was observed in the basal lamina and lamina propria of regenerative mucosa. IL-6 was increased significantly in regenerative mucosa after injury, especially at 14 days post wounding when compared with normal mucosa. IL-8 was also increased significantly in regenerative mucosa; however, IL-10 was decreased significantly when compared with normal mucosa. IL-6 and IL-8 showed a significant correlation with the expression level of collagen type I.

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Section: Discussionsupporting

confidence: 47%

Serial cytokine levels during wound healing in rabbit maxillary sinus mucosa

Sun

Wang

et al. 2009

Acta Oto-Laryngologica

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“…IL-12 is the most significant cytokine in the transformation of Th0 cells to Th1 cells. However, scholars have demonstrated that IL-10 is highly expressed in nasal polyp tissues (21). DCs are not only able to secrete IL-10 themselves but are also able to induce T cells to secrete IL-10 (15).…”

Section: Discussionmentioning

confidence: 99%

Expression and distribution of dendritic cells in nasal polyps

Lin

Luo

Wang

et al. 2013

Experimental and Therapeutic Medicine

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The aim of the present study was to investigate the expression, distribution and function of dendritic cells (DCs) and to study their role in nasal polyps. The study involved 55 participants, 45 of whom had nasal polyps and were the study group and 10 who had normal inferior turbinates and were the control group. Immunohistochemical staining was used to visualize the expression and distribution of the S-100 protein. A double immunostaining method was used to visualize the CD1a and CD40 expression and the images were analyzed with Axioplan 2 microscopy. The expression level of the S-100 protein in the nasal polyps was higher than that in the normal inferior turbinates with a significant difference (P<0.01). The distribution area, number and density of the double stained cells in the nasal polyps were all greater than in the normal inferior turbinates (P<0.01). The S-100 protein and double stained cells were mainly located in the lamina propria below the mucous membrane. The present study demonstrates that DCs are involved in the pathogenesis of nasal polyps and the presence of CD40-positive DCs suggests that this was related to the reciprocal interaction between the DCs and T lymphocytes.

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“…Invitro effects of RANTES on eosinophils include chemotaxis, transendothelial migration, induction and production of reactive oxygen, and the release of ECP [28]. IL-8 is predominantly a chemoattractant for neutrophils as well as for eosinophils after these target cells have been primed with IL-5 [21,26]. Positive correlations between concentration of IL-2 and nasal symptom score, endoscopic score and Lund-Mackay score is difficult to explain.…”

Section: Discussionmentioning

confidence: 99%

“…IL-10 is an anti-inflammatory Th2 cytokine produced by T-lymphocytes, monocytes and macrophages. It is considered to inhibit the release of IFN-c and the cytokine synthesis of monocytes and leads to marked immunosupression [26].…”

Section: Discussionmentioning

confidence: 99%

Correlation Between Cytokine Levels in Nasal Fluid and Scored Clinical Parameters in Patients with Nasal Polyposis

Perić

Vojvodić

Radulović

et al. 2012

Indian J Otolaryngol Head Neck Surg

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The aim of this study was to compare the cytokine levels in nasal fluid in subjects with nasal polyposis (NP) and co-morbid asthma and NP patients without asthma and to correlate these levels with clinical parameters of severity of disease. Forty NP patients (20 asthmatic and 20 nonasthmatic) were enrolled. Nasal secretion samples were collected from nasal cavities of all 40 subjects. The levels of Th1 cytokines IL-2, IL-12 and IFN-c, Th2 cytokines IL-4, IL-5, IL-6, and IL-10, chemokine IL-8, and proinflammatory cytokines IL-1b, TNF-a and TNF-b were measured using flow cytometric method. Each of the 40 patients was staged clinically according to global nasal symptom score, endoscopic score, and Lund-Mackay computed tomography (CT) score. The concentrations of Th2 cytokines IL-5, IL-6 and IL-10 were significantly higher (P \ 0.01, P \ 0.01, P \ 0.05) in patients with NP and asthma compared with NP patients without asthma.Positive correlations were observed between concentration of IL-2 in nasal secretions and global nasal symptom score, endoscopic score, and Lund-Mackay score only in NP patients without asthma. We also found positive correlation between CT score and the levels of IL-8, IL-4, and IL-1b in nonasthmatic patients. Finally, our results showed a positive correlation between IL-5 levels in nasal fluid and endoscopic score only in asthmatic patients. NP in asthmatic patients have different immunological patterns compared to those without asthma. We also concluded that concentrations of cytokines measured in nasal fluid were not sensitive enough to determine the severity of disease.

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Expression of Interleukin-5, Interleukin-8, and Interleukin-10 mRNA in the Osteomeatal Complex in Nasal Polyposis

Abstract: IL-5 cytokine expression in the osteomeatal complex is linked to the presence of nasal polyps, whereas IL-8 is up-regulated without distinct correlation to nasal polyps. IL-10 expression was detectable in five of eight allergic patients.

Cited by 23 publications

References 22 publications

Serial cytokine levels during wound healing in rabbit maxillary sinus mucosa

Serial cytokine levels during wound healing in rabbit maxillary sinus mucosa

Expression and distribution of dendritic cells in nasal polyps

Correlation Between Cytokine Levels in Nasal Fluid and Scored Clinical Parameters in Patients with Nasal Polyposis

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