Expression of interleukin‐18 and its monokine‐directed function in rheumatoid arthritis

Möller, Burkhard; Kukoc-Zivojnov, Natasa; Kessler, U.; Rehart, Stefan; Kaltwasser, J. P.; Hoelzer, Dieter; Kalina, Uwe; Ottmann, Oliver G.

doi:10.1093/rheumatology/40.3.302

Cited by 35 publications

(32 citation statements)

References 26 publications

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“…Endothelial cells and monocyte/macrophages also represent important sources of IL-18BP. The circulating levels of IL-18BP in healthy individuals range from 0.5 to 7 ng/ml, while elevated IL-18BP levels have been described in several autoimmune or inflammatory diseases (77,(94)(95)(96)(97). In Crohn's disease, IL-18BPa, IL-18BPc, and IL-18BPd isoforms were elevated in samples from patients with active disease, and intestinal endothelial cells and macrophages were the major source of IL-18BP in the submucosa (98).…”

Section: Il-18bpmentioning

confidence: 99%

IL‐1, IL‐18, and IL‐33 families of cytokines

Arend

Palmer

Gabay

2008

Immunological Reviews

774

647

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Summary: The interleukin-1 (IL-1), IL-18, and IL-33 families of cytokines are related by mechanism of origin, receptor structure, and signal transduction pathways utilized. All three cytokines are synthesized as precursor molecules and cleaved by the enzyme caspase-1 before or during release from the cell. The NALP-3 inflammasome is of crucial importance in generating active caspase-1. The IL-1 family contains two agonists, IL-1a and IL-1b, a specific inhibitor, IL-1 receptor antagonist (IL1Ra), and two receptors, the biologically active type IL-1R and inactive type II IL-1R. Both IL-1RI and IL-33R utilize the same interacting accessory protein (IL-1RAcP). The balance between IL-1 and IL-1Ra is important in preventing disease in various organs, and excess production of IL-1 has been implicated in many human diseases. The IL-18 family also contains a specific inhibitor, the IL-18-binding protein (IL-18BP), which binds IL-18 in the fluid phase. The IL-18 receptor is similar to the IL-1 receptor complex, including a single ligand-binding chain and a different interacting accessory protein. IL-18 provides an important link between the innate and adaptive immune responses. Newly described IL-33 binds to the orphan IL-1 family receptor T1/ST2 and stimulates T-helper 2 responses as well as mast cells.

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Section: Il-18bpmentioning

confidence: 99%

IL‐1, IL‐18, and IL‐33 families of cytokines

Arend

Palmer

Gabay

2008

Immunological Reviews

774

647

View full text Add to dashboard Cite

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“…IL-18 protein was detected in the PBMC cell lysates by western blotting as published recently [22]. In brief, cell pellets were washed twice in phosphate buffered saline, solved in 100 µl of lysis buffer solution containing 20 mM TRIS (pH 8.0), 137 mM NaCl, Glycerol 10 %, Nonidet P-40 1 %, 10 mM EDTA, 100 mM NaF, 1 mM PMSF, 100 U Aprotinin, 20 µM Na-Orthovanadat, and 4 µM Leupeptin at 4°C for 30 min.…”

Section: Il-18 Western Blot Analysismentioning

confidence: 99%

“…In contrast to an elevated IL-18 expression in RA joints [10,22], IL-18 expression in RA-PBMC is significantly reduced by yet unknown mechanisms [22]. In this context, we like to remind that RA patients have an increased risk of developing severe, life-threatening infections [23].…”

Section: Introductionmentioning

confidence: 99%

Prednisolone induces interleukin-18 expression in mononuclear blood and myeloid progenitor cells

et al. 2002

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“…Since the presence of high levels of TNF-·, IL-1ß and IL-6 in the synovial fluid of rheumatoid arthritis has been reported [16][17][18], the effect of TAC-101 on IL-1ß-induced PGE 2 and/or IL-6 production by MG-63 was examined. TAC-101 inhibited the production of PGE 2 but not IL-6 by MG-63 cells ( fig.…”

Section: Effect Of Tac-101 On Pge 2 and Il-6 Production By Mg-63 Cellsmentioning

confidence: 99%

Effect of Synthetic Retinoid, TAC-101, on Experimental Autoimmune Disease

Miyagawa

Homma²,

Kagechika³

et al. 2002

Pharmacology

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The effect of 4-[3,5-bis(trimethylsilyl)benzamido] benzoic acid (TAC-101), one of the synthetic retinoids, on collagen-induced arthritis (CIA) in mice and experimental autoimmune encephalomyelitis (EAE) in rats was studied. TAC-101 at doses of 5 and 20 mg/kg clearly inhibited the development of CIA in terms of the swelling of fore- and hind-limbs and bone destruction in knee joints. TAC-101 also suppressed the production of anti-type II collagen (CII) IgG antibody and delayed-type hypersensitivity (DTH) against CII. In addition, TAC-101 delayed the onset and development of EAE but did not affect the maximum symptom of EAE in rats. The elevation of serum antimyelin basic protein (MBP) antibody and DTH to MBP on day 13 clearly suppressed by TAC-101 in EAE rats. Moreover, TAC-101 inhibited the IL-1β-induced PGE₂ production by MG-63 cells, human osteoblast-like cells, through the suppression of cyclooxygenase II mRNA expression. These findings suggest that TAC-101 inhibits CIA in mice and EAE in rats due to the suppression of immune response to auto-antigen and the production of PGE₂.

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Expression of interleukin‐18 and its monokine‐directed function in rheumatoid arthritis

Cited by 35 publications

References 26 publications

IL‐1, IL‐18, and IL‐33 families of cytokines

IL‐1, IL‐18, and IL‐33 families of cytokines

Prednisolone induces interleukin-18 expression in mononuclear blood and myeloid progenitor cells

Effect of Synthetic Retinoid, TAC-101, on Experimental Autoimmune Disease

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