Expression of intercellular adhesion molecules on circulating lymphocytes in relation to different manifestations of cow's milk allergy

Österlund, Pamela; Smedberg, T.; Schröder, Jim; Järvinen, Kirsi-Marjut

doi:10.1046/j.1365-2222.2003.01787.x

Cited by 8 publications

(3 citation statements)

References 30 publications

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“…Herein we showed that endogenously activated PF-derived NK cells express increased amounts of ICAM-1 and LFA-1 molecules, as has been observed in peripheral lymphocytes from other inflammatory diseases [32][33][34]. Furthermore, we observed differential expression of ICAM-1 and LFA-1, which is consistent with the functional divergent activities of CD56 bright and CD56 dim subsets [7].…”

Section: Discussionsupporting

confidence: 85%

“…The role of ICAM-1 has been widely studied in APC and endothelial cells, however, little is known about its expression and function on human lymphocytes in an inflammatory context [31][32][33][34]. To address this, we evaluated ICAM-1 expression on lymphocyte subpopulations in PBMC and PF mononuclear cells (PFMC) from patients with tuberculous pleurisy (TB-PF).…”

Section: Nk Cells From Tuberculous Pleural Fluid Express High Icam-1 mentioning

confidence: 99%

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NK cells from tuberculous pleurisy express high ICAM‐1 levels and exert stimulatory effect on local T cells

et al. 2009

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Tuberculous pleurisy, one of the most common manifestations of extrapulmonary tuberculosis, is characterized by a T-cell-mediated hypersensitivity reaction along with a Th1 immune profile. In this study, we investigated functional cross-talk among T and NK cells in human tuberculous pleurisy. We found that endogenously activated pleural fluidderived NK cells express high ICAM-1 levels and induce T-cell activation ex vivo through ICAM-1. Besides, upon in vitro stimulation with monokines and PAMP, resting peripheral blood NK cells increased ICAM-1 expression leading to cellular activation and Th1 polarization of autologous T cells. Furthermore, these effects were abolished by anti-ICAM-1 Ab. Hence, NK cells may contribute to the adaptive immune response by a direct cellcontact-dependent mechanism in the context of Mycobacterium tuberculosis infection.Key words: ICAM-1 . NK cells . Pleurisy . Th1 . Tuberculosis Supporting Information available online IntroductionPleuritis is the most frequent clinical manifestation of extrapulmonary tuberculosis (TB) among young adults, and is normally considered a relatively benign form of disease since it may resolve without chemotherapy [1]. Tuberculous pleurisy is caused by a severe delayed-type hypersensitivity reaction in response to the rupture of a subpleural focus of Mycobacterium tuberculosis (Mtb) infection, but it may also be developed as a complication of primary pulmonary TB [2,3]. This pleural effusion is characterized by a strong granulomatous inflammatory response to Mtb together with high levels of . NK cells are CD56 1 CD16 1/À /CD3 À CD19 À lymphocytes of the innate immune system whose function is controlled by an array of germline-encoded activator/inhibitory receptors [5,6]. Two subsets of NK cells have been identified in humans according to CD56 expression differing in phenotype and function, and also in terms of chemokine receptors and adhesion molecules expression [7,8,9]. Functionally, CD56 bright cells are effective cytokine producers, whereas CD56 dim cells are efficient effectors of natural and Ab-dependent target cell lysis. Recently, we have described that an endogenously activated pleural fluid NK (PF-NK) population is a major source of IFN-g in response to Mtb [10,11]. Consistently, PF-NK are enriched in CD56 bright cells, as has been observed in other chronic inflammatory sites [12,13] or in tumor-affected tissues [14]. Together with the classical NK functions (i.e. cytotoxicity and cytokine production), novel skills have recently been described in niche-specific and in vitro-activated human NK cells. These unconventional capabilities include [16,17,18] and direct pathogen recognition [19,20]. In this regard, a novel innate immune cell population called Interferon-producing killer dendritic cells has been recently described in mice [21,22].ICAM-1/CD54 is the major ligand of costimulatory a L b 2 integrin (CD11a/CD18), commonly known as lymphocyte function-associated antigen (LFA-1) [23,24]. The surface enhancement of ICAM-1 on endothelial, APC and...

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Section: Discussionsupporting

confidence: 85%

Section: Nk Cells From Tuberculous Pleural Fluid Express High Icam-1 mentioning

confidence: 99%

NK cells from tuberculous pleurisy express high ICAM‐1 levels and exert stimulatory effect on local T cells

et al. 2009

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“…Circulating peripheral blood lymphocytes (PBLs) generally express an inactive form of LFA-1, which is crucial to maintain homeostasis, since constitutively active LFA-1 can cause instantaneous aggregation of circulating cells and clogging of the vessels. Activation of LFA-1 is a prerequisite for ligand binding [19,20]. Binding of Mn 2+ directly activates LFA-1, whereas Mg 2+ supports LFA-l-mediated adhesion only when some additional stimuli (e.g.…”

Section: Function Of Lfa-1mentioning

confidence: 99%

Leukocyte Function-Associated Antigen-1: Structure, Function and Application Prospects

Ma¹,

Wenyun²,

Wang

2006

PPL

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This review focuses on the structure, function and pathological role of leukocyte function-associated antigen-1 (LFA-1) which is a heterodimeric protein consisting of two subunits. LFA-1 plays a most important role in the immune system including adhesion, extravasation, migration, apoptosis, cytotoxicity, cytokine production, and proliferation of lymphocytes. Therefore, T-cell activation can be suppressed by blocking ICAM-1/LFA-1 interaction in autoimmune diseases and organ transplantation. Many different inhibitors (i.e. antibodies, peptides, small molecules) have been demonstrated to block ICAM-1/LFA-1 interaction, and some of them are promising for medical treatment or have reached clinical trials.

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Quoi de neuf en allergologie pédiatrique en 2004 ? Partie 3 : allergie cutanée, alimentaire, médicamenteuse et aux venins d'insectes (Une revue de la littérature internationale d'octobre 2003 à septembre 2004)

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2005

Revue Française d'Allergologie et d'Immunologie Clinique

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Expression of intercellular adhesion molecules on circulating lymphocytes in relation to different manifestations of cow's milk allergy

Cited by 8 publications

References 30 publications

NK cells from tuberculous pleurisy express high ICAM‐1 levels and exert stimulatory effect on local T cells

NK cells from tuberculous pleurisy express high ICAM‐1 levels and exert stimulatory effect on local T cells

Leukocyte Function-Associated Antigen-1: Structure, Function and Application Prospects

Quoi de neuf en allergologie pédiatrique en 2004 ? Partie 3 : allergie cutanée, alimentaire, médicamenteuse et aux venins d'insectes (Une revue de la littérature internationale d'octobre 2003 à septembre 2004)

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