Abstract:Objective To investigate the expression of insulin-like growth factor binding protein-3(IGFBP-3) in HELLP syndrome and its possible role in the pathogenesis of this disease.Methods 1) 87 subjects were enrolled, including 29 patients with HELLP syndrome, 29 patients with simple pre-eclampsia(PE), and 29 healthy gravidae as control. The expression of IGFBP-3, IGF-1, TGF- β1, and VEGF in maternal and umbilical blood of them were detected using ELISA. Correlation analysis was used to observe the correlation between… Show more
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