Expression of insulin-like growth factor-1 (IGF-1) and growth hormone-receptor (GHR) mRNA in liver, skeletal muscle and adipose tissue of different breeds of pig

Brameld, John M.; Atkinson, Joanne; Budd, T.J.; Saunders, John C.; Pell, J. M.; Salter, Andrew M.; Gilmour, R. Stewart; Buttery, P. J.

doi:10.1017/s1357729800015101

Cited by 14 publications

(7 citation statements)

References 26 publications

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“…It was. also found that major levels of class 2 transcripts (exon 2-containing transcripts) of IGF-I were only present in the liver, a result also found in other whole-animal pig studies looking at differences with age (Brameld et al 1995a) and breed of pig (Brameld et al 1996~). Increased growth rates were accompanied by an increase in the proportion of class 2 IGF-I mRNA in the liver, suggesting a role for class 2 IGF-I in the endocrine growth response.…”

Section: Effects Of Manipulating Energy Availabilitysupporting

confidence: 72%

Molecular mechanisms involved in the nutritional and hormonal regulation of growth in pigs

Brameld

1997

Proc. Nutr. Soc.

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Section: Effects Of Manipulating Energy Availabilitysupporting

confidence: 72%

Molecular mechanisms involved in the nutritional and hormonal regulation of growth in pigs

Brameld

1997

Proc. Nutr. Soc.

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“…Even if circulating IGF-I concentrations in gilts were similar between breeds at the end of gestation, the IGF system could still be involved in the different metabolism of the two genotypes. Indeed, even though no differences in liver IGF-I mRNA expression levels were reported at 85 kg BW between breeds, the expression of IGF-I mRNA in muscle and adipose tissue was lower in Meishan than Large White pigs (Brameld et al 1996).…”

Section: Discussionmentioning

confidence: 83%

“…The literature reports no difference in IGF-I concentrations between Meishan (or Meishan crosses) and European breeds at a body weight of 85 kg (Brameld et al 1996), between 10 and 140 d of age (Louveau et al 1991) and at 80 d (Louveau and Bonneau 1996). On the other hand, values were lower in Meishan than LW boars from 20 to 52 wk of age (Weiler et al 1998), and in Meishan than LW pigs at 185 (Louveau and Bonneau 1996;Louveau et al 1991) and 365 d of age (Louveau et al 1991).…”

Section: Discussionmentioning

confidence: 98%

Glucose and hormonal profiles of Meishan-derived and Large White gilts in early and late gestation

Farmer¹

2003

Can. J. Anim. Sci.

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Farmer, C. 2003. Glucose and hormonal profiles of Meishan-derived and Large White gilts in early and late gestation. Can. J. Anim. Sci. 83: 73-79. Jugular catheters were inserted non-surgically in eight Large White (LW) and nine Genex-Meishan (GM, with 50% Meishan genes) gilts on days 37 and 106 of gestation to obtain serial blood samples on days 38 and 107. Meal time was 0805. Three preprandial samples (baseline) were obtained at 0740, 0750 and 0800 as well as samples every 20 min thereafter until 1100. Glucose and insulin concentrations were measured in all samples and values for cortisol and insulin-like growth factor-I (IGF-I) were determined on preprandial samples and hourly samples thereafter. All gilts were weighed and their backfat thickness measured at mating and on days 17, 34 and 109 of gestation. Gilts of the GM line were lighter (P = 0.03) and fatter (P = 0.004) than LW. Postprandial values for cortisol and IGF-I were greater in GM than LW gilts in early gestation only (P < 0.05). The same was true for baseline IGF-I (P < 0.001). Postprandial insulin was not affected by breed or stage of gestation (P > 0.1), yet glucose values were greater in LW than in GM gilts (P < 0.05) and postprandial glucose was greater in late compared to early gestation in both breeds (P < 0.001). In conclusion, both cortisol and IGF-I concentrations varied differently between genotypes depending on the stage of gestation. Furthermore, even though postprandial insulin was not affected by breed, concentrations of glucose were lower in GM gilts. A metabolic adaptation to gestation was observed in both breeds, with glucose values increasing in later gestation. n'étaient pas affectées par la race ou le stade de gestation (P > 0,1), cependant, celles du glucose étaient plus élevées chez les cochettes LW comparativement aux GM (P < 0,05) et étaient supérieures en fin de gestation dans les deux races (P < 0,001). En conclusion, les concentrations de cortisol et d'IGF-I variaient différemment entre génotype dépendant du stade de gestation. De surcroît, malgré le fait que les concentrations d'insuline aient été similaires entre les races, celles du glucose étaient plus élevées chez les LW que chez les GM. Il semble qu'une adaptation métabolique au stade de gestation ait lieu chez les deux races, tel qu'indiqué par des concentrations plus élevées de glucose en fin de gestation

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“…However, circulating insulin concentrations have been shown to broadly correlate with circulating IGF-I concentrations (Dawson et al 1998), and thus it is logical to speculate that animals fed dried grass might have had higher plasma IGF-I concentrations. IGF-I production is believed to be associated with the hepatic response to growth hormone, an association modulated by nutritional status (Brameld et al 1996) and insulin (McGuire et al 1995). As IGF-I is believed to mediate the protein anabolic effects of growth hormone (Douglas et al 1991), it is likely that the greater rates of carcass protein gain in animals fed dried grass compared with grass silage were in part mediated by this hormone.…”

Section: Insulinmentioning

confidence: 99%

Fat and protein metabolism in growing steers fed either grass silage or dried grass

et al. 2006

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Cattle fed grass silage diets have been reported to have high carcass fat:protein ratios. The effect of grass silage and dried grass diets, fed at different levels of intake to ensure a range of equivalent metabolisable energy intakes (MEI) from 1 ·1 £ metabolisable energy requirement for maintenance to ad libitum, on fat and protein metabolism in twenty-four Hereford £ Friesian steers was investigated. After about 84 d of dietary treatment rates of whole-body fat and protein metabolism were measured, as were rates of lipogenesis in omental, perirenal and subcutaneous adipose tissue. Carcass composition was determined. Animals fed silage had greater (P,0 ·001) carcass fat:protein ratios than animals fed dried grass at equivalent levels of MEI. Animals fed silage had lower (P,0 ·001) rates of protein gain. Rates of leucine entry and oxidation were lower (P,0 ·001) in animals fed silage, but there was no dietary difference in the rate of whole-body protein synthesis. There was no dietary difference in the rate of carcass fat gain, but rates of lipogenesis in perirenal adipose tissue were significantly (P¼ 0 ·007) higher in animals fed silage. There was no dietary difference in the rate of palmitate and glycerol entry or palmitate oxidation. There were no interactions between MEI and diet, indicating that increments of energy were utilised with the same efficiency from both diets. It was concluded that the high carcass fat: protein ratios of young growing steers was due to limited rates of protein accretion and not to elevated rates of carcass fat accretion. Grass silage forms the basis of many winter diets fed to beef cattle in the UK. The performance of animals fed silage is variable and often disappointing in terms of feed intake and the overall efficiency of energy (Thomas & Chamberlain, 1990) and amino acid (Beever et al. 1992;MacRae et al. 1995) utilisation. It has been reported that animals fed silage have a high carcass fat:protein ratio (Lonsdale, 1976;Moore & Steen, 1983;Baker et al. 1985Baker et al. , 1992Steen & Moore, 1988Steen, 1991). That protein deposition is limited in animals fed grass silage is now well established (Gill et al. 1987). Whether or not fat deposition is increased in these animals is unclear.With continuing pressures to increase the utilisation of grass in ruminant production systems, a greater understanding of the partition of nutrients between fat and protein deposition in animals fed grass silage is required if useful models to predict animal performance are to be developed. The objective of the present study was to determine whether or not an increased fat deposition contributes to the high carcass fat:protein ratio of animals fed grass silage by simultaneously investigating fat and protein metabolism, using isotope dilution and incorporation techniques, and carcass composition of young, growing steers fed either grass silage or dried grass. As both the quantity and form of metabolisable energy (ME) are considered to be important determinants of animal performance (Beever et al. ...

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Expression of insulin-like growth factor-1 (IGF-1) and growth hormone-receptor (GHR) mRNA in liver, skeletal muscle and adipose tissue of different breeds of pig

Cited by 14 publications

References 26 publications

Molecular mechanisms involved in the nutritional and hormonal regulation of growth in pigs

Molecular mechanisms involved in the nutritional and hormonal regulation of growth in pigs

Glucose and hormonal profiles of Meishan-derived and Large White gilts in early and late gestation

Fat and protein metabolism in growing steers fed either grass silage or dried grass

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