Expression of inhibitory receptors on peripheral blood T cells in pregnant women with preeclampsia
E. A. Smetanenko,
N. A. Khonina,
O. Y. Leplina
et al.
Abstract:Maternal adaptation of the immune system aimed at limiting the immune response to fetal antigens is a necessary condition for a successful pregnancy. It involves various mechanisms (Th1/Th2 switching, Treg expansion, induction of anergy and apoptosis of T lymphocytes, development of T cell depletion) that are induced through the ligation of inhibitory receptors. Accordingly, the expression of inhibitory receptors on T cells, including PD-1, CTLA-4, and Tim-3 molecules, may reflect the effectiveness of immune… Show more
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