Expression of immunoglobulin D is increased in chronic rhinosinusitis

Sokoya, Mofiyinfolu; Ramakrishnan, Vijay R.; Frank, Daniel N.; Rahkola, Jeremy; Getz, Anne E.; Kingdom, Todd T.; Kofonow, Jennifer M.; Nguyen, Quyen; Janoff, Edward N.

doi:10.1016/j.anai.2017.07.024

Cited by 12 publications

(12 citation statements)

References 35 publications

(37 reference statements)

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“…However, regarding local IgD production in patients with CRSwNP, inconsistent results have been reported. 17,18 In this study, using several complimentary techniques, we demonstrated increased production of secretory IgD in Chinese patients with patients with CRSwNP. Interestingly, patients with eosinophilic CRSwNP demonstrated the highest levels of local IgD.…”

Section: Discussionmentioning

confidence: 59%

“…Upregulation of local IgD production in patients with CRSsNP has been reported previously. 17,18 Min et al 17 found that local soluble IgD levels were greater in those with preoperative antibiotic use or pathogenic bacteria presence, suggesting a potential involvement of IgD in immune response to bacterial infection in patients with CRSsNP. However, regarding local IgD production in patients with CRSwNP, inconsistent results have been reported.…”

Section: Discussionmentioning

confidence: 99%

“…14 Recently, 2 studies investigated local IgD expression in patients with CRS, and conflicting results were reported. 17,18 Min et al 17 found increased numbers of mucosal IgD 1 cells in patients with CRSsNP but not those with CRSwNP, 17 whereas Sokoya et al 18 demonstrated enhanced accumulation of IgD 1 cells in both patients with CRSsNP and those with CRSwNP. 18 Nevertheless, more importantly, the specificity and function of IgD have not been explored in those studies.…”

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confidence: 99%

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IgD-activated mast cells induce IgE synthesis in B cells in nasal polyps

Zhai

Wang

et al. 2018

Journal of Allergy and Clinical Immunology

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Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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IgD-activated mast cells induce IgE synthesis in B cells in nasal polyps

Zhai

Wang

et al. 2018

Journal of Allergy and Clinical Immunology

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“…IgDR is also be found to present on neoplastic B-cells [13]. However, the Furthermore, high sIgD levels were reported in Hodgkin's lymphoma [7] and chronic rhinosinusitis [34]. Recently, we found that serum sIgD levels in patients with RA were significantly higher than that in healthy controls [15].…”

Section: Discussionmentioning

confidence: 99%

Immunoglobulin D (IgD) and IgD receptor expression in diffuse large B-cell lymphoma

Dai

Jia

et al. 2019

Hematology

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Objective: Immunoglobulin D (IgD) levels are often elevated in patients with autoimmune diseases. However, the oncogenic activities of IgD and IgD receptor (IgDR) in diffuse large Bcell lymphoma (DLBCL) have not been reported in detail. Therefore, we aimed to investigate the expression of IgD and IgDR in patients with DLBCL. Methods: Membrane IgD (mIgD) and IgDR expression in tissue samples was analyzed using IHC, mIgD and IgDR expression on peripheral blood mononuclear cells (PBMCs) was analyzed by FCM, and secreted IgD (sIgD) level was analyzed by ELISA. Fisher's exact test and Spearman correlation analysis were used to evaluate the relationship between IgD, IgDR, and clinical parameters. Results: The pathological lymph nodes of 34 patients with DLBCL were studied, and mIgD and IgDR expression was found in 16 and 19 patients. mIgD and IgDR expression was upregulated in patients with DLBCL and mIgD expression was significantly associated with IgDR expression. Further correlation analysis showed that mIgD expression was correlated with serum β 2-MG level and Hans algorithm as germinal center B (GCB), whereas IgDR expression correlated with serum LDH level, IPI score and GCB. ELISA showed that sIgD level was significantly increased in DLBCL patients and it correlated with serum β 2-MG and LDH levels. FCM showed that mIgD and IgDR expression in PBMCs of patients with DLBCL was significantly higher than that in healthy controls. Conclusion: Our findings suggest that overexpression of IgD and IgDR is an abnormal activation state in DLBCL.

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“…At baseline, IgD levels were significantly higher in the atopic asthma group compared to the control group, and normalized during the next 18 months during asthma treatment [5]. Two very recent publications show a role for IgD in rhinosinusitis [6,7] and suggest that IgD might contribute to enhance mucosal immunity, inflammation, or respond to bacterial infections.…”

Section: Introductionmentioning

confidence: 99%

Serum IgD Levels in Allergic Children with Gastrointestinal Manifestations

Knipping¹

2018

PNBOA

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A large number of studies investigating various biomarkers for allergy have been published over the past decades. To this date, no single or specific biomarker for allergy has been identified. Therefore, we examined markers of inflammation and immunoglobulins in children with allergic symptoms, among which children with GI allergy, in an attempt to find new and indicative markers for GI allergy. In the present study, total serum levels of immunoglobulin (Ig)D, CM-lgE, Ig-free light chain (Ig-fLC) kappa and lambda, thymic stromal lymphopoietin (TSLP), thymus and activation-regulated chemokine (TARC/CCL17) and galectin-9 were analyzed on 117 atopic infants and children, divided into different allergic manifestations: asthma (n=7), atopic dermatitis (n=56), eosinophilic esophagitis (n=20) and gastrointestinal (GI) allergy (n=34). Elevated levels of serum IgD, without the presence of IgE, was found in children with GI allergy. Serum IgD did not correlate with other laboratory parameters of atopy such as serum cow's milk-lgE, Ig-fLC, TSLP, TARC and galectin-9. In conclusion, serum IgD is elevated in children with GI allergy, in the absence of IgE, and can be considered as a new indicative marker for GI allergy, however, its exact role in the pathogenesis of atopy awaits further studies.

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Expression of immunoglobulin D is increased in chronic rhinosinusitis

Cited by 12 publications

References 35 publications

IgD-activated mast cells induce IgE synthesis in B cells in nasal polyps

IgD-activated mast cells induce IgE synthesis in B cells in nasal polyps

Immunoglobulin D (IgD) and IgD receptor expression in diffuse large B-cell lymphoma

Serum IgD Levels in Allergic Children with Gastrointestinal Manifestations

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