Expression of IL-6, IL-10, IL-17 and IL-33 in the peri-implant crevicular fluid of patients with peri-implant mucositis and peri-implantitis

Severino, Viviane Oliveira; Beghini, Marcela; Araújo, Márcia Fernandes de; Melo, Marcelo Luiz Ribeiro de; Miguel, Camila Botelho; Rodrigues, Wellington Francisco; Pereira, Sanívia Aparecida de Lima

doi:10.1016/j.archoralbio.2016.08.021

Cited by 53 publications

(56 citation statements)

References 41 publications

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“…It is conspicuous in chronic inflammation surrounding implants, leading to osteoclastic activation and peri‐implant bone loss . These correspond to the pattern of IL‐6 increase in concentration between H and MU; H and PI . To our knowledge, this is the first meta‐analysis investigating IL‐6 in H, MU, and PI.…”

Section: Discussionsupporting

confidence: 55%

See 1 more Smart Citation

Use of IL‐1 β, IL‐6, TNF‐α, and MMP‐8 biomarkers to distinguish peri‐implant diseases: A systematic review and meta‐analysis

Ghassib

Chen

Zhu

et al. 2018

Clin Implant Dent Rel Res

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Objective To investigate the use of peri‐implant crevicular fluid (PICF) interleukin‐1β (IL‐1β), IL‐6, tumor necrosis factor‐α (TNF‐α), and matrix metalloproteinase‐8 (MMP‐8) biomarkers in distinguishing between healthy implants (H), peri‐implant mucositis (MU), and peri‐implantitis (PI). Material and Methods Electronic using three databases (Pubmed, EMBASE, and Cochrane) and manual searches were conducted for articles published up to March 2018 by two independent calibrated reviewers. Meta‐analyses using a random‐effects model were conducted for each of the cytokines; IL‐1β, IL‐6, and TNF‐α, to analyze standardized mean difference (SMD) between H and MU, MU and PI, H and PI with their associated 95% confidence intervals (CI). Qualitative assessment of MMP‐8 was provided consequent to the lack of studies that provide valid data for a meta‐analysis. Results Nineteen articles were included in this review. IL‐1β, IL‐6, and TNF‐α, levels were significantly higher in MU than H groups (SMD: 1.94; 95% CI: 0.87, 3.35; P < .001, SMD: 1.17; 95% CI: 0.16, 3.19; P = .031 and SMD: 3.91; 95% CI: 1.13, 6.70; P = .006, respectively). Similar results were obtained with PI compared to H sites (SMD: 2.21, 95% CI: 1.32, 3.11; P < .001, SMD: 1.72; 95% CI: 0.56, 2.87; P = .004 and SMD: 3.78; 95% CI: 1.67, 5.89; P < .001, respectively). IL‐6 was statistically higher in PI than MU sites (SMD = 1.46; 95% CI: 0.36, 2.55; P = .009); while IL‐1ß increase was not significant. Despite absence of meta‐analysis, MMP‐8 show to be a promising biomarker in detection of PI in literature. Conclusion Within the limitations of this study, pro‐inflammatory cytokines in PICF, such as IL‐1ß and IL‐6, can be used as adjunct tools to clinical parameters to differentiate H from MU and PI.

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Section: Discussionsupporting

confidence: 55%

“…51 H and PI. 33,55 To our knowledge, this is the first meta-analysis investigating IL-6 in H, MU, and PI. IL-6 was found to be more sensitive to severity of inflammation in peri-implant tissues.…”

Section: Publication Biasmentioning

confidence: 95%

Use of IL‐1 β, IL‐6, TNF‐α, and MMP‐8 biomarkers to distinguish peri‐implant diseases: A systematic review and meta‐analysis

Ghassib

Chen

Zhu

et al. 2018

Clin Implant Dent Rel Res

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“…Moreover, IL-6 protein expression in gastric cancer tissue is higher than that in adjacent normal mucosa and is associated with TNM stage (37). IL-6 and IL-17 levels were high in peri-implantitis of oral cavity, suggesting that these cytokines promote local inflammatory processes (38). In the present study, we found that IL-6 expression in adenocarcinoma cases was higher than that in dysplasia, metaplasia, and gastritis cases, which is consistent with the findings of previous studies (35).…”

Section: Discussionmentioning

confidence: 97%

Cytokine expression associated with Helicobacter pylori and Epstein‐Barr virus infection in gastric carcinogenesis

Kim

Bae

Kang

et al. 2017

APMIS

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Helicobacter pylori and Epstein-Barr virus (EBV) infection, and associated cytokines are involved in gastric carcinogenesis. We investigated the expression of these cytokines and their relationship with clinicopathological characteristics. The study included specimens from 207 patients with gastric adenocarcinoma, 56 with chronic gastritis, 32 with metaplasia, and 30 with low-grade epithelial dysplasia. Tissue microarrays were constructed and immunohistochemical staining for IL-1β, IL-6, IL-10, IL-17, p16, p21, TNF-α, and TNFR1 was performed. EBV and H. pylori infection status was determined. IL-1β, IL-6, IL-17, p16, and p21 protein expression was significantly higher in adenocarcinoma cases than in the other cases (p < 0.05). EBV was only noted in adenocarcinoma (13 cases, 6.3%). The H. pylori infection rate in adenocarcinoma was significantly higher than that in the other cases (p < 0.005). IL-6 expression was associated with improved survival (p < 0.05), whereas IL-17 expression was associated with decreased survival (p < 0.05). IL-6 expression was inversely associated with angioinvasion, and disease stage (p < 0.05), whereas IL-17 expression was associated with disease stage (p < 0.05). IL-10 expression was correlated with IL-1β and TNF-α expression, and p16 expression was correlated with IL-17 and EBV status. Our results indicate that IL-6 and IL-17 are associated with gastric carcinogenesis and may be considered prognostic factors.

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“…[37] In recent implant studies, IL-33 levels in peri-implantar crevicular fluid were seen to be significantly higher in peri-implantitis and peri-implant mucositis group when compared to healthy group. [38] Peri-implant fluid levels of IL-33 from mucositis sites were seen to be independent of the degree of bone resorption around implants or teeth. [39]…”

Section: Discussionmentioning

confidence: 99%

Higher interleukin-33 levels in aggressive periodontitis cases

Ballambettu

Pradeep

Purushottam

et al. 2019

J Indian Soc Periodontol

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Expression of IL-6, IL-10, IL-17 and IL-33 in the peri-implant crevicular fluid of patients with peri-implant mucositis and peri-implantitis

Cited by 53 publications

References 41 publications

Use of IL‐1 β, IL‐6, TNF‐α, and MMP‐8 biomarkers to distinguish peri‐implant diseases: A systematic review and meta‐analysis

Use of IL‐1 β, IL‐6, TNF‐α, and MMP‐8 biomarkers to distinguish peri‐implant diseases: A systematic review and meta‐analysis

Cytokine expression associated with Helicobacter pylori and Epstein‐Barr virus infection in gastric carcinogenesis

Higher interleukin-33 levels in aggressive periodontitis cases

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