Expression of IL‐33 and its receptor ST2 in chronic rhinosinusitis with nasal polyps

Baba, Satoru; Kondo, Kenji; Kanaya, Kaori; Suzukawa, Keigo; Ushio, Munetaka; Urata, Shinji; Asakage, Takahiro; Kakigi, Akinobu; Suzukawa, Maho; Ohta, Ken; Yamasoba, Tatsuya

doi:10.1002/lary.24462

Cited by 61 publications

(51 citation statements)

References 29 publications

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“…540,541 Some evidence suggests that IL-33 may play a role as well, but these studies have yet to demonstrate increased expression of this cytokine at the protein level in NP tissue. 374,[542][543][544] In regard to IL-25, evidence in CRS is scant. As mentioned earlier in this section EC chemokines also play a major role in the attraction and activation of innate effector cells including eosinophils, mast cells, neutrophils, macrophages, and likely ILCs.…”

Section: Discussionmentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

554

888

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Background:The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). Methods:Evidence-based reviews with recommendations (EBRRs) were developed for scores of topics, using previously reported methodology. Where existing evidence was insufficient for an EBRR, an evidence-based review (EBR) was produced. The sections were then synthesized and the entire manuscript was then reviewed by all authors for consensus. Results:The resulting ICAR:RS document addresses multiple topics in RS, including acute RS (ARS), chronic RS (CRS) with and without nasal polyps (CRSwNP and CRSsNP), recurrent acute RS (RARS), acute exacerbation of CRS (AE-CRS), and pediatric RS. Conclusion:As a critical review of the RS literature, ICAR:RS provides a thorough review of pathophysiology and evidence-based recommendations for medical and surgical treatment. It also demonstrates the significant gaps in our understanding of the pathophysiology and optimal management of RS. Too o en the foundation upon which these recommendations are based is comprised of lowerlevel evidence. It is our hope that this summary of the evidence in RS will point out where additional research efforts may be directed. C 2016 ARS-AAOA, LLC. Key Words:rhinosinusitis; chronic rhinosinusitis; acute rhinosinusitis; recurrent acute rhinosinusitis; evidence-based medicine; systematic review; endoscopic sinus surgery List of Abbreviations Used

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Section: Discussionmentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

554

888

View full text Add to dashboard Cite

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“…More recently, expression of IL-33 and its receptor ST2 was also investigated in patients with CRS,19 – 21 and two of these studies reported elevated expression of ST2,19 20 implying that the IL-33/ST2 pathway may function in nasal polypogenesis. Despite these findings, the specific role of IL-33 in the pathophysiology of patients with CRSwNP still remains unclear.…”

Section: Introductionmentioning

confidence: 99%

The role of interleukin-33 in chronic rhinosinusitis

Kim

Jin

Eun

et al. 2016

Thorax

103

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“…An eosinophil count of 50 per microscopic field (magnification ×400) was chosen to distinguish between ECRSwNP and nECRSwNP, as described previously [9]. Symptom scores were assessed according to the visual analog scale (VAS) and Sino-Nasal Outcome Test-20 (SNOT-20).…”

Section: Methodsmentioning

confidence: 99%

“…Some studies have found that NPs of Asian patients are less eosinophilic as compared to those of a Western population and that mast cells might be involved as much as eosinophils in the mucosal pathogenesis of NPs in Asian patients [9]. Other studies have found that interleukin-33 (IL-33) is involved in the pathogenesis of various allergic diseases and, therefore, may act as a therapeutic target.…”

Section: Introductionmentioning

confidence: 99%

IL-33 Expression in Chronic Rhinosinusitis with Nasal Polyps and Its Relationship with Clinical Severity

Song

Wang²,

Zhou³

et al. 2017

ORL

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Background: Chronic rhinosinusitis (CRS) is a heterogeneous disease characterized by epithelial inflammation and tissue eosinophilic infiltration. Interleukin-33 (IL-33) is a key inflammatory cytokine that mediates eosinophilic infiltration. Objective: The aim of our study was to investigate the expression and role of IL-33 in eosinophilic CRS with nasal polyps (ECRSwNP) and in noneosinophilic CRS with nasal polyps (nECRSwNP), and to analyze their correlation with clinical severity. Methods: The study enrolled 25 patients with ECRSwNP, 27 patients with nECRSwNP, and 12 control subjects, based on immunohistochemical staining. Protein and mRNA expressions of IL-33 in sinus mucosal samples were determined by immunohistochemistry and real-time polymerase chain reaction. Sino-Nasal Outcome Test-20 (SNOT-20) score, visual analog scale (VAS) score, endoscopy score, and computed tomography (CT) score were assessed preoperatively. Results: IL-33 expression levels in the CRSwNP group were significantly higher than those in the control group (p < 0.01), especially in the ECRSwNP group (p < 0.05). There were no significant differences between the ECRSwNP and nECRSwNP groups with respect to SNOT-20 score, VAS score, endoscopy score, or CT score. IL-33 mRNA expression showed a positive correlation with the number of eosinophils (p < 0.05) and endoscopy score (p < 0.05) but not with VAS score and CT score. Conclusion: IL-33 expression plays an important role in patients with CRSwNP. No significant differences were observed between the ECRSwNP and nECRSwNP groups with respect to SNOT-20 score, VAS score, endoscopy score, or CT score. IL-33 expression was correlated with eosinophil counts and endoscopy score.

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Expression of IL‐33 and its receptor ST2 in chronic rhinosinusitis with nasal polyps

Abstract: N/A.

Cited by 61 publications

References 29 publications

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

The role of interleukin-33 in chronic rhinosinusitis

IL-33 Expression in Chronic Rhinosinusitis with Nasal Polyps and Its Relationship with Clinical Severity

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