Expression of Il-10 and Ki-67 in Some Benign and Malignant Salivary Gland Tumors "An Immunohistochemical Study"

Abstract

INTRODUCTION: Salivary gland tumors (SGTs) are infrequent tumors representing 2.5-7 % of all head and neck tumors. It's very difficult to reach proper diagnosis and prognosis depending on histomorphologic criteria alone due to overlapping clinicopathologic features. IL-10 is a homodimeric protein that has various anti-inflammatory and immune functions. In cancer, IL-10 has both immunosuppressive properties and anti-angiogenic properties. Several studies proved the prognostic role of IL-10 in different human cancers. However, its role in SGTs still needs to be confirmed. Ki-67 is a nuclear protein that is encoded by the gene MKi-67. Its expression as a proliferative cell and a prognostic marker has been largely investigated in many types of human tumors including those of salivary gland origin, such as acinic cell and adenoid cystic carcinomas. OBJECTIVES: To evaluate IL-10 and Ki-67 immunoexpression in benign and malignant SGTs. MATERIAL AND METHODS: IL-10 and Ki-67 expression was measured in 30 SGT cases (15 benign and 15 malignant) and 15 normal salivary gland tissue (NSGT). Immunohistochemical (IHC) staining was carried out by the Labeled Strept-Avidin Biotin complex method (LSAB). RESULTS: IL-10 and Ki-67 expression was detected in normal salivary gland tissues (NSGT) as well as benign and malignant salivary gland tumors (SGTs) with different intensities. The Lowest expression levels were detected in normal salivary gland tissues, while the highest were detected in malignant salivary gland tumors. CONCLUSION: IL-10 and Ki-67 could be used as prognostic markers in salivary gland tumors.

Immunohistochemical Expression of Ki-67 in Malignant Salivary Glands Tumors

“…21 In another study, Ki-67 expression was highest in malignant salivary gland tumors compared to benign tumors and normal tissues. 22 Adenoid cystic carcinomas showed higher Ki-67 expression compared to mucoepidermoid carcinomas and polymorphous adenocarcinomas. It may aid in distinguishing ADCC from other malignant tumors.…”

Mitotic Index and Immunohistochemical Expression of Ki-67 in Pleomorphic Adenoma of Salivary Glands

“…Literature revealed role of Ki-67 in Pleomorphic adenoma and its variable expression. 9,10,11,12 The biological behavior of PA is variable in few cases due to its transformation into CaExPA. Its diagnosis is usually made by conventional histopathological examination and potential malignant transformation is determined by counting mitotic activity however role of immunohistochemistry i.e.…”