Expression of IFNg and TGFb1 genes can distinguish radiation workers from the normal population

Abstract

Ionising radiation can cause different forms of DNA damage in living cells. Changes in biomarkers due to exposure to ionising radiation can be an appropriate tool for the immediate recognition of individuals exposed to radiation after a radiological accident or nuclear disaster. QPCR technique, as an approved method, was used for analysing the expression levels of sensitive genes following radiation exposure. Gene expression studies were performed on a group of 36 radiation workers and 36 matched-normal people without a history of radiation exposure. Mean gene expression values for control and irradiated groups were compared. There was significant difference between the mean gene expression of IFNg (p < 0.05), also significant difference was observed between the gene expression of TGFb1 (p < 0.05) in normal and irradiated groups. The logistic regression model is able to correctly identify 72.2% of irradiated samples (sensitivity) and 80.6% of normal samples (specificity). He has been advisor to many MSc and PhD student and has published over 50 scientific papers, and presented more than 50 oral and poster presentations at international conferences. He is co-author of two books written in Persian (medical physics and computed tomography) and co-translator of a book on radiation protection.

Evaluation of Technical and Protective Functions; Radiology Department Staff of Zahedan University of Medical Sciences

“…The European Union has developed a program entitled "guidelines for quality of radiographic quality" and recommended countries to follow its guidelines. Exposure to an excessive amount of ionizing radiation may negatively influence the genes, hematopoietic cells, and central nerves (10)(11)(12). Besides, it may cause problems for the surface of the body (such as burns, cataracts, and scales) (13).…”