1998
DOI: 10.1128/iai.66.7.3029-3034.1998
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Expression of Legionella pneumophila Virulence Traits in Response to Growth Conditions

Abstract: In nature, Legionella pneumophila replicates exclusively as an intracellular parasite of amoebae, but it also persists in the environment as a free-living microbe. Studies of how this opportunistic pathogen recognizes and responds to distinct extracellular and intracellular environments identified a link between the growth phase and expression of traits previously correlated with virulence. When cultured in broth, only post-exponential-phase L. pneumophila was sodium sensitive, cytotoxic, osmotically resistant… Show more

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Cited by 336 publications
(301 citation statements)
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“…Our data also show that several cas genes, along with the CRISPR RNA, are up-regulated during postexponential growth (Fig. S3A), a growth phase that mimics the condition immediately prior to L. pneumophila lysis from the host cell and its transit through the extracellular environment (Byrne and Swanson, 1998). We next asked if these systems were indeed active (able to defend against protospacer-containing foreign DNA).…”
Section: B a Venn Diagrammentioning
confidence: 72%
“…Our data also show that several cas genes, along with the CRISPR RNA, are up-regulated during postexponential growth (Fig. S3A), a growth phase that mimics the condition immediately prior to L. pneumophila lysis from the host cell and its transit through the extracellular environment (Byrne and Swanson, 1998). We next asked if these systems were indeed active (able to defend against protospacer-containing foreign DNA).…”
Section: B a Venn Diagrammentioning
confidence: 72%
“…In vitro studies have shown that nutrient limitation at the post-exponential phase is the signal that triggers dramatic phenotypic modulations in L. pneumophila, and that is most likely to be the signal that triggers virulence traits at the post-exponential phase within macrophages (Byrne and Swanson, 1998;Hammer and Swanson, 1999;Bachman and Swanson, 2001;Hammer et al, 2002). It is well documented that the ability of L. pneumophila to replicate intracellularly is dependent on the bacterial growth phase (Byrne and Swanson, 1998).…”
Section: Discussionmentioning
confidence: 99%
“…It is well documented that the ability of the Philadelphiaderived Lp02 strain of L. pneumophila to replicate intracellularly is totally dependent on the bacterial growth phase (Byrne and Swanson, 1998;Hammer and Swanson, 1999;Bachman and Swanson, 2001;Hammer et al, 2002). While post-exponentialL.…”
Section: Growth Phase-independent Virulence Of L Longbeachaeamentioning
confidence: 99%
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