1996
DOI: 10.1111/j.1600-0722.1996.tb00078.x
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Expression of c‐erbB‐2 protein in keratinocytes of oral mucosal lichen planus and subsequent squamous cell carcinoma

Abstract: Oral mucosal lichen planus (OMLP) is a well recognized mucosal disease with unknown etiology. Considerable controversy exists as to whether OMLP is intrinsically premalignant, or if the disorder facilitates the development of oral mucosal squamous cell carcinoma (OMSCC) by external factors. The aim of the present study was to investigate the expression of c-erbB-2 protein in the keratinocytes of initial biopsies or oral mucosal disorders diagnosed as OMLP with no evidence of epithelial dysplasia, and to compar… Show more

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Cited by 21 publications
(25 citation statements)
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“…To uncover some of the molecular genetic aberrations associated with OLP, investigators have used molecular and genetic methods such as loss of heterozygosity (LOH) (Zhang et al, 2000), chromosome in situ hybridization (Kim et al, 2001), p53 and c-erbB2 expression (Girod et al, 1994(Girod et al, , 1995Kilpi et al, 1996;Ogmundsdottir et al, 2002), and telomerase activity (O'Flatharta et al, 2002). However, none of these methods appears to provide definitive predictive information with regard to the malignant potential of a lesion diagnosed as OLP.…”
Section: Chromosomal Numerical Aberrations In Oral Lichen Planusmentioning
confidence: 97%
“…To uncover some of the molecular genetic aberrations associated with OLP, investigators have used molecular and genetic methods such as loss of heterozygosity (LOH) (Zhang et al, 2000), chromosome in situ hybridization (Kim et al, 2001), p53 and c-erbB2 expression (Girod et al, 1994(Girod et al, , 1995Kilpi et al, 1996;Ogmundsdottir et al, 2002), and telomerase activity (O'Flatharta et al, 2002). However, none of these methods appears to provide definitive predictive information with regard to the malignant potential of a lesion diagnosed as OLP.…”
Section: Chromosomal Numerical Aberrations In Oral Lichen Planusmentioning
confidence: 97%
“…The generally accepted statement lies in that both malignant and host cells have been shown to produce cytokine networks and induce DNA damage, cell growth and immortalization, angiogenesis, invasion and metastasis [11]. Although numerous investigations have begun to identify genetic and protein aberrations within OLP, few of them were focused on the progression of OLP to oral cancer [12, 13]. Since only a few percent of the patients with OLP progress to oral squamous cell carcinoma (OSCC), we do not know whether these molecular alterations within OLP have significant role in malignant transformation.…”
Section: Introductionmentioning
confidence: 99%
“…Positive correlations have been found with variables, such as stage, metastasis, or overall survival in some [8-10, 14, 20, 22, 27-29], but not all of the studies [6,11,13,14,17,19,24], while simultaneous expression of multiple ERBB receptors has been suggested as a better indicator of decreased survival [8,10]. Loss of Her-2 immunostaining has been considered as an indicator of neoplastic transformation potential in premalignant lesions [18,[30][31][32], although there are reports to the contrary [32,33].…”
Section: Introductionmentioning
confidence: 97%