Expression of hypothalamic regulatory peptides in thyroid C cells of different mammals

Utrilla, José C.; Morillo-Bernal, Jesús; Gordillo-Martínez, Flora; García-Marín, Rocío; Herrera, José; Fernández-Santos, José M.; Díaz-Parrado, Eduardo; Garnacho, Carmen; Miguel, Manuel de; Martín-Lacave, Inés

doi:10.1016/j.ygcen.2013.02.048

Cited by 7 publications

(7 citation statements)

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“…Ghrelin also immunocolocalizes with calcitonin in normal C cells of different mammals (Utrilla et al 2013), and C cells are also able to secrete ghrelin (Morillo-Bernal et al 2011). GHS-R1a and GPR39, the discussed receptor of obestatin, have been detected more in thyroid tissues of patients with Graves' disease than in those with non-toxic or toxic nodular goiter (Bossowski et al 2013).…”

Section: Autoimmune Thyroiditismentioning

confidence: 99%

“…Ghrelin is a circulating acylated peptide that promotes a strong release of growth hormone (GH) through binding to and activation of its receptor GH secretagogue receptor type 1a (GHS-R1a) in hypothalamus and pituitary (Kojima et al 1999;van der Lely et al 2004). In recent times, ghrelin gained popularity as the ''hunger hormone'' because its secretion, mainly from the stomach, is regulated by fasting and, in turn, it induces appetite, promotes adiposity, and controls energy homeostasis (Ariyasu et al 2001;Tschöp et al 2000;Wren et al 2001).…”

Section: Introductionmentioning

confidence: 99%

“…Plasma concentration of ghrelin rises during fasting, drops to basal values after the assumption of food, and it could contribute to meal initiation or choose of nutrients (Cummings 2006). Ghrelin is commonly altered in pathological conditions affecting body mass and/or body energy metabolism, negatively correlating with body mass index (BMI) (van der Lely et al 2004). Ghrelin circulating levels are indeed lower in overweight or obese subjects than in normal individuals (Tschöp et al 2000), with the exception of Prader Willi syndrome (Cummings et al 2002), and higher in conditions characterized by energy inadequacy such as anorexia/cachexia associated with cancer (Garcia et al 2005;Shimizu et al 2003) and several other pathologies including chronic heart and renal failure, chronic obstructive pulmonary disease (COPD), and cystic fibrosis (Cohen et al 2008;Itoh et al 2004;Nagaya et al 2001;Yoshimoto et al 2002).…”

Section: Introductionmentioning

confidence: 99%

“…Ghrelin circulating levels are indeed lower in overweight or obese subjects than in normal individuals (Tschöp et al 2000), with the exception of Prader Willi syndrome (Cummings et al 2002), and higher in conditions characterized by energy inadequacy such as anorexia/cachexia associated with cancer (Garcia et al 2005;Shimizu et al 2003) and several other pathologies including chronic heart and renal failure, chronic obstructive pulmonary disease (COPD), and cystic fibrosis (Cohen et al 2008;Itoh et al 2004;Nagaya et al 2001;Yoshimoto et al 2002). Insulin and glucose are among the major determinants of ghrelin secretion that, in turn, modulates insulin secretion and glucose metabolism (van der Lely et al 2004;Wiedmer et al 2007). Recently, the specific acyltransferase that octanoylates ghrelin (GOAT: ghrelin O-acyltransferase) was detected in human circulation in healthy, obese, and anorexic adults with a positive correlation with BMI and a negative correlation with ghrelin levels (Goebel-Stengel et al 2013).…”

Section: Introductionmentioning

confidence: 99%

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Ghrelin Gene Products in Acute and Chronic Inflammation

Prodam,

Filigheddu

2014

Arch. Immunol. Ther. Exp.

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Ghrelin gene products-the peptides ghrelin, unacylated ghrelin, and obestatin-have several actions on the immune system, opening new perspectives within neuroendocrinology, metabolism and inflammation. The aim of this review is to summarize the available evidence regarding the less known role of these peptides in the machinery of inflammation and autoimmunity, outlining some of their most promising therapeutic applications.

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Section: Autoimmune Thyroiditismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Ghrelin Gene Products in Acute and Chronic Inflammation

Prodam,

Filigheddu

2014

Arch. Immunol. Ther. Exp.

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“…Ghrelin has been demonstrated in parafollicular cells and medullary thyroid cancer cells [12][13][14]. Ghrelin binding sites have been shown in the thyroid [6] and exogenous ghrelin uptake in the thyroid gland was demonstrated to be notably higher than in other tissues [15].…”

Section: Introductionmentioning

confidence: 99%

Ghrelin and obestatin in thyroid gland — immunohistochemical expression in nodular goiter, papillary and medullary cancer

Gurgul

Kasprzak

Błaszczyk

et al. 2015

Folia Histochem Cytobiol.

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Introduction. Previous studies analyzing ghrelin and obestatin expression in thyroid gland tissue are not unanimous and are mostly related to ghrelin. The role of ghrelin and obestatin in the thyroid gland appears very interesting due to their probable involvement in cell proliferation. Furthermore, since the thyroid gland is associated with the maintenance of energy balance, the relationship between ghrelin, obestatin and thyroid function is worthy of consideration. The aim of the study was to assess ghrelin and obestatin immunocytochemical expression in nodular goiter (NG), papillary cancer (PTC) and medullary cancer (MTC). Material and methods. Analyzed samples included 9 cases of NG, 8 cases of PTC and 11 cases of MTC. The analysis of ghrelin and obestatin expression was performed by use of the immunohistochemical (IHC) EnVision system and evaluated with filter HSV software (quantitative morphometric analysis). Results. Quantitative ghrelin expression in MTC cells was higher than in NG (p = 0.013) and correlated negatively with the size of the tumor (r= -0.829, p < 0.05). We did not observe any differences in ghrelin expression neither between MTC and PTC nor between NG and PTC. Obestatin immunoexpression pattern in all analyzed specimens was irregular and poorly accented. The strongest immunoreactivity for obestatin was demonstrated in NG. In MTC obestatin expression was significantly weaker than in NG and PTC (p < 0.05 in both cases). In NG the intensity of obestatin immunostaining was significantly higher than that of ghrelin (p = 0.03). Conversely, ghrelin expression in MTC was definitely more evident than obestatin immunoreactivity (p < 0.01). There was no statistically significant difference between ghrelin and obestatin expression in PTC. No correlations were detected between reciprocal tissue expressions of ghrelin and obestatin in the analyzed specimens of NG, PTC or MTC. Conclusions. The differences between ghrelin expression in NG and MTC suggest that ghrelin may be involved in thyroid cell proliferation. The differences between ghrelin and obestatin immunoreactivity in benign and malignant thyroid tumors could support the theory of alternative transcription of the preproghrelin gene and independent production of ghrelin and obestatin.

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C‐cell differentiation in the wall of an aberrant ultimobranchial sinus in the thyroid gland of an old rat

Vázquez-Román

Fernández-Santos

Martín-Lacave

2022

Veterinary Medicine & Sci

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Background In mammals, the thyroid gland possesses two types of endocrine cells, follicular cells and C cells, which have different functions but share a similar endodermal origin (although from different regions of the primitive pharynx). Specifically, follicular cells derive from the ventral pharyngeal floor, while C cells derive from the fourth pair of pharyngeal pouches through the ultimobranchial bodies (UBBs). Disruptions to human midline thyroid morphogenesis are relatively frequent and known as thyroid dysgenesis, which is the leading cause of congenital hypothyroidism. In contrast, fourth branchial apparatus anomalies are very rare clinical entities. Objectives The aim of this study was to analyze the morphological features and the immunohistochemical pattern of an aberrant ultimobranchial remnant, align with its persistent contribution to the formation of new C cells. Methods The thyroid gland of an old rat was serially sectioned and immunostained for the following markers: calcitonin, thyroglobulin, cytokeratins, PCNA, P63, E‐cadherin, beta‐tubulin and CD3. Results We detected a spontaneous congenital defect in the organogenesis of the UBB in an old rat, giving rise to an ‘ultimobranchial sinus’, which was accompanied by thymic tissue and an abscess. The epithelium contained basal/stem cells and contributed to the formation of abundant C cells and scarce follicular cells. Conclusions The ultimobranchial sinus is an exceptional finding for representing the first spontaneous abnormality in the development of UBB reported in rats, and the opportunity to observe sustained C‐cell differentiation from stem cells in an old rat. These findings are consistent with a common origin of both C cells and follicular cells from UBB.

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Expression of hypothalamic regulatory peptides in thyroid C cells of different mammals

Cited by 7 publications

References 58 publications

Ghrelin Gene Products in Acute and Chronic Inflammation

Ghrelin Gene Products in Acute and Chronic Inflammation

Ghrelin and obestatin in thyroid gland — immunohistochemical expression in nodular goiter, papillary and medullary cancer

C‐cell differentiation in the wall of an aberrant ultimobranchial sinus in the thyroid gland of an old rat

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