Expression of human miR-200b-3p and -200c-3p in cytomegalovirus-infected tissues

Lee, Kyoung Hwa; Lim, Beom Jin; Ferreira, Victor H; Min, Seo Yeon; Hong, Yeon-Mi; Jo, Jeong-Hyeon; Han, Sanghoon

doi:10.1042/bsr20180961

Cited by 14 publications

(14 citation statements)

References 33 publications

(33 reference statements)

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“…The majority (634 of 687 patients, 92.3%) of patients in the exposed group had the ICD-10 code B25.8 (other cytomegaloviral disease) or B25.9 (cytomegaloviral disease, unspecified). This finding may indicate that the CMV-infected organs were mainly those of the gastrointestinal tract including the oesophagus, stomach, colon, and rectum, and is supported by another study using CMV-infected formalin-fixed paraffin-embedded tissue in our hospital [40]. We did not find that the differential risk of moderate-to-severe dementia varied by CMV-infected organs.…”

Section: Discussionsupporting

confidence: 78%

Association between cytomegalovirus end-organ diseases and moderate-to-severe dementia: a population-based cohort study

et al. 2020

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Background: The association between cytomegalovirus (CMV) and dementia remains controversial. Previous studies have suggested that CMV serostatus, as assessed by serum immunoglobulin G, plays a role in neurodegeneration with cognitive impairment. We aimed to evaluate the association between CMV tissue-invasive end-organ diseases and moderate-to-severe dementia. Methods: The ICD 10th revision codes from the National Health Insurance Database covering the entire population of the Republic of Korea were used to classify patients into exposed (n = 687, age ≥ 40 years, with CMV disease) and unexposed (n = 3435, without CMV disease) groups, matched by age and sex at a 1:5 ratio of exposed: unexposed. All non-HIV-1-infected subjects selected during 2010-2014 with a washout period of the previous 4 years were followed up until December 2016 to identify newly diagnosed cases of moderate-to-severe dementia. Results: Multivariate regression model (M3) adjusted for age, sex, low income, body mass index, transplantation status, malignant neoplasms, end-stage renal disease on dialysis, type 2 diabetes mellitus, hypertension, and dyslipidaemia showed a significantly higher incidence of dementia (odds ratio: 1.9; 95% confidence interval: 1.2-2.8) in the exposed group than that in the unexposed group. The risk of vascular dementia (2.9, 1.1-7.5) was higher than that of Alzheimer's disease (1.6, 1.0-2.6) in the exposed group in M3. In M3, patients aged 40-59 years with CMV diseases had a significantly higher risk of all kinds of dementia than those aged 60-79 and ≥ 80 years (11.7, 2.5-49.4 vs. 1.8, 1.1-3.2 vs. 1.3, 0.5-2.8; P = 0.025). Conclusions: CMV diseases may be associated with the risk of moderate-to-severe dementia.

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Section: Discussionsupporting

confidence: 78%

Association between cytomegalovirus end-organ diseases and moderate-to-severe dementia: a population-based cohort study

et al. 2020

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“…(other cytomegaloviral disease) or B25.9 (cytomegaloviral disease, unspecified). This finding may indicate that the CMV-infected organs were mainly those of the gastrointestinal tract including the oesophagus, stomach, colon, and rectum, and is supported by another study using CMV-infected formalin-fixed paraffin-embedded tissue in our hospital [40]. We did not find that the differential risk of moderate-to-severe dementia varied by CMV-infected organs.…”

Section: Discussionsupporting

confidence: 78%

Association Between Cytomegalovirus End-organ Diseases and Moderate-to-Severe Dementia: A Population-Based Cohort Study

Lee

Kwon

Han

et al. 2020

Preprint

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Background: The association between cytomegalovirus (CMV) and dementia remains controversial. Previous studies have suggested that CMV serostatus, as assessed by serum immunoglobulin G, plays a role in neurodegeneration with cognitive impairment. We aimed to evaluate the association between CMV tissue-invasive end-organ diseases and moderate-to-severe dementia. Methods: The ICD 10th revision codes from the National Health Insurance Database covering the entire population of the Republic of Korea were used to classify patients into exposed (n = 687, age ≥40 years, with CMV disease) and unexposed (n = 3,435, without CMV disease) groups, matched by age and sex at a 1:5 ratio of exposed: unexposed. All non-HIV-1-infected subjects selected during 2010–2014 with a washout period of the previous 4 years were followed up until December 2016 to identify newly diagnosed cases of moderate-to-severe dementia. Results: Multivariate regression model (M3) adjusted for age, sex, low income, body mass index, transplantation status, malignant neoplasms, end-stage renal disease on dialysis, type 2 diabetes mellitus, hypertension, and dyslipidaemia showed a significantly higher incidence of dementia (odds ratio: 1.9; 95% confidence interval: 1.2–2.8) in the exposed group than that in the unexposed group. The risk of vascular dementia (2.9, 1.1–7.5) was higher than that of Alzheimer’s disease (1.6, 1.0–2.6) in the exposed group in M3. In M3, patients aged 40–59 years with CMV diseases had a significantly higher risk of all kinds of dementia than those aged 60-79 and ≥80 years (11.7, 2.5–49.4 vs. 1.8, 1.1–3.2 vs. 1.3, 0.5–2.8; P =0.025). Conclusions: CMV diseases may be associated with the risk of moderate-to-severe dementia.

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“…The neuroprotector thymosin beta 4 showed promise in mouse models subjected to severe traumatic brain injury, raising the serum levels of both miR-200a-3p and miR-200b-3p [117]. Interestingly, miR-200b-3p and miR-200c-3p have been identified as indicators of cytopathic inflammation produced by cytomegalovirus (CMV) infection [118]. Nonetheless, the means through which this miRNA contributes to the pathophysiology of BAVMs remain ambiguous.…”

Section: Mir-200b-3pmentioning

confidence: 99%

An Insight into the microRNAs Associated with Arteriovenous and Cavernous Malformations of the Brain

Florian

Buruiană

Şuşman

et al. 2021

Cells

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Background: Brain arteriovenous malformations (BAVMs) and cerebral cavernous malformations (CCMs) are rare developmental anomalies of the intracranial vasculature, with an irregular tendency to rupture, and as of yet incompletely deciphered pathophysiology. Because of their variety in location, morphology, and size, as well as unpredictable natural history, they represent a management challenge. MicroRNAs (miRNAs) are strands of non-coding RNA of around 20 nucleotides that are able to modulate the expression of target genes by binding completely or partially to their respective complementary sequences. Recent breakthroughs have been made on elucidating their contribution to BAVM and CCM occurrence, growth, and evolution; however, there are still countless gaps in our understanding of the mechanisms involved. Methods: We have searched the Medline (PubMed; PubMed Central) database for pertinent articles on miRNAs and their putative implications in BAVMs and CCMs. To this purpose, we employed various permutations of the terms and idioms: ‘arteriovenous malformation’, ‘AVM’, and ‘BAVM’, or ‘cavernous malformation’, ‘cavernoma’, and ‘cavernous angioma’ on the one hand; and ‘microRNA’, ‘miRNA’, and ‘miR’ on the other. Using cross-reference search; we then investigated additional articles concerning the individual miRNAs identified in other cerebral diseases. Results: Seven miRNAs were discovered to play a role in BAVMs, three of which were downregulated (miR-18a, miR-137, and miR-195*) and four upregulated (miR-7-5p, miR-199a-5p, miR-200b-3p, and let-7b-3p). Similarly, eight miRNAs were identified in CCM in humans and experimental animal models, two being upregulated (miR-27a and mmu-miR-3472a), and six downregulated (miR-125a, miR-361-5p, miR-370-3p, miR-181a-2-3p, miR-95-3p, and let-7b-3p). Conclusions: The following literature review endeavored to address the recent discoveries related to the various implications of miRNAs in the formation and growth of BAVMs and CCMs. Additionally, by presenting other cerebral pathologies correlated with these miRNAs, it aimed to emphasize the potential directions of upcoming research and biological therapies.

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Expression of human miR-200b-3p and -200c-3p in cytomegalovirus-infected tissues

Cited by 14 publications

References 33 publications

Association between cytomegalovirus end-organ diseases and moderate-to-severe dementia: a population-based cohort study

Association between cytomegalovirus end-organ diseases and moderate-to-severe dementia: a population-based cohort study

Association Between Cytomegalovirus End-organ Diseases and Moderate-to-Severe Dementia: A Population-Based Cohort Study

An Insight into the microRNAs Associated with Arteriovenous and Cavernous Malformations of the Brain

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