Expression of Human Chemerin Induces Insulin Resistance in the Skeletal Muscle but Does Not Affect Weight, Lipid Levels, and Atherosclerosis in LDL Receptor Knockout Mice on High-Fat Diet

Becker, Melanie; Rabe, Katja; Lebherz, Corinna; Zugwurst, Julia; Göke, Burkhard; Parhofer, Klaus G.; Lehrke, Michael; Broedl, Uli C.

doi:10.2337/db10-0362

Cited by 93 publications

(75 citation statements)

References 24 publications

(44 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is possible that in obesity, elevated levels of chemerin predominantly induce insulin resistance in muscle and even if chemerin stimulates β-cell function and suppresses gluconeogenesis in the liver, the net glucose tolerance may be deteriorated. It has been reported that serum chemerin levels were associated with insulin resistance in mice [35] and humans [17], which supports this hypothesis.…”

Section: Discussionsupporting

confidence: 74%

Decreased serum chemerin levels in male Japanese patients with type 2 diabetes: sex dimorphism

Takahashi

Inomata²,

Okimura

et al. 2013

Endocr J

View full text Add to dashboard Cite

TYPE 2 DIABETES MELLITUS (T2DM)results from the development of insulin resistance and a concomitant impairment of insulin secretion. Under these conditions, adipokines, which are secreted by the adipose tissue, play a pivotal role [1,2]. Adipokines such as leptin, adiponectin, and resistin regulate energy and glucose homeostasis. Adipocytes also secrete inflamDecreased serum chemerin levels in male Japanese patients with type 2 diabetes: sex dimorphism Abstract. Chemerin, a recently discovered adipocytokine plays an important role in obesity and obesity-associated metabolic complications. However, the role of chemerin in the pathogenesis of type 2 diabetes mellitus (T2DM) has not fully been elucidated. We compared the serum chemerin levels and metabolic parameters between 88 control subjects, 86 patients with metabolic syndrome (MS), and 147 patients with T2DM in a Japanese population and further analyzed their correlation. Enzyme-linked immunosorbent assay was used to measure the serum chemerin levels. The chemerin levels were significantly higher in male than in female control subjects (p < 0.005), with significant decreases in patients with T2DM compared with those with MS and control subjects (164.9 ± 6.3 ng/mL vs. 209.8 ± 7.7 and 218.7 ± 7.3 ng/mL; p < 0.0001 vs. p < 0.0001, respectively) but no significant differences in female subjects. The multiple regression analysis revealed that the chemerin levels negatively correlated with the fasting glucose and HbA1c levels in total and male subjects. In the patients with T2DM, the chemerin levels negatively correlated with fasting glucose and high-density lipoprotein cholesterol but positively correlated with body mass index (BMI), and total cholesterol and triglyceride levels. The negative correlation between the chemerin and fasting glucose levels remained significant after adjustment for age, sex, and BMI in the total and male subjects and those with T2DM. These results suggest the role of chemerin in sex dimorphism and a potential link between chemerin levels and T2DM pathogenesis in a Japanese population.

show abstract

Section: Discussionsupporting

confidence: 74%

Decreased serum chemerin levels in male Japanese patients with type 2 diabetes: sex dimorphism

Takahashi

Inomata²,

Okimura

et al. 2013

Endocr J

View full text Add to dashboard Cite

show abstract

“…Hart and Greaves 31) showed that chemerin rapidly stimulated the adhesion of macrophages to the extracellular matrix protein, fibronectin, and to the adhesion molecule, vascular cell adhesion molecule-1, suggesting that chemerin might promote the progression of atherosclerosis. Although Becker et al 32) showed that the Independent variables in multiple stepwise regression analysis: gender, age, body mass index, waist circumference, systolic blood pressure, diastolic blood pressure, fasting blood glucose, LDL-cholesterol, HDL-cholesterol, triglycerides, high sensitivity C-reactive protein, and chemerin baPWV, brachial ankle pulse wave velocity; SE, standard error; R expression of chemerin did not significantly alter the extent of atherosclerosis in LDL receptor knockout mice, they hypothesized that chemerin may affect early atherosclerotic plaque development and plaque morphology rather than the extent of the atherosclerotic lesion area. Furthermore, Kaur et al 33) demonstrated the novel presence of a G-protein coupled chemerin receptor (CMKLR1) in human endothelial cells and its significant up-regulation by pro-inflammatory cytokines (TNF-, IL-1 , and IL-6).…”

Section: Fig 1 Correlation Between Circulating Chemerin Levels and mentioning

confidence: 98%

Circulating Chemerin Level is Independently Correlated with Arterial Stiffness

Yoo

Choi

Yang

et al. 2012

JAT

View full text Add to dashboard Cite

Aim: Adipokines have been implicated in the pathogenesis of obesity and obesity-related disorders, including atherosclerosis. Chemerin is a recently discovered adipokine which is closely correlated with various metabolic phenotypes in humans. We examined the association between circulating chemerin levels and arterial stiffness, as represented by the brachial ankle pulse wave velocity (baPWV). Methods: Fifty-eight obese and 62 non-obese individuals participated in the study. We measured the serum chemerin and high sensitivity C-reactive protein ( Conclusions:The circulating chemerin level was an independent risk factor for arterial stiffness even after adjusting for other cardiovascular risk factors.

show abstract

“…Chemerin is an attractant for immune cells and pro-and antiinflammatory effects of chemerin have been described . More recently it has been shown that chemerin impairs insulin signaling in adipocytes and skeletal muscle cells (Becker et al, 2010;Kralisch et al, 2009;Sell et al, 2009). …”

Section: Introductionmentioning

confidence: 99%

Adiponectin upregulates hepatocyte CMKLR1 which is reduced in human fatty liver

Wanninger¹,

Walter²,

Bauer³

et al. 2012

Z Gastroenterol

View full text Add to dashboard Cite

Chemokine-like receptor 1 (CMKLR1) ligands chemerin and resolvin E1 are suggested to have a role in non-alcoholic fatty liver disease (NAFLD). Here, expression of CMKLR1 in liver cells and NAFLD was studied. CMKLR1 was detected in primary human hepatocytes (PHH), Kupffer cells, bile-duct cells and hepatic stellate cells. In human and rodent fatty liver and in fibrotic liver of mice fed a methionine-choline deficient diet CMKLR1 was reduced. Hepatocytes are the major cells in the liver and effects of adipokines, cytokines and lipids on CMKLR1 in PHH were analyzed. Increased cellular triglyceride or cholesterol content, lipopolysaccharide, IL-6, TNF and leptin did not influence CMKLR1 levels in PHH whereas profibrotic TGFβ tended to reduce CMKLR1. Adiponectin strongly upregulated CMKLR1 mRNA and protein in PHH and hepatic CMKLR1 when injected into wild type mice. Further, CMKLR1 was suppressed in the liver of adiponectin deficient mice. These data indicate that low CMKLR1 in NAFLD may partly result from reduced adiponectin activity.

show abstract

Expression of Human Chemerin Induces Insulin Resistance in the Skeletal Muscle but Does Not Affect Weight, Lipid Levels, and Atherosclerosis in LDL Receptor Knockout Mice on High-Fat Diet

Cited by 93 publications

References 24 publications

Decreased serum chemerin levels in male Japanese patients with type 2 diabetes: sex dimorphism

Decreased serum chemerin levels in male Japanese patients with type 2 diabetes: sex dimorphism

Circulating Chemerin Level is Independently Correlated with Arterial Stiffness

Adiponectin upregulates hepatocyte CMKLR1 which is reduced in human fatty liver

Contact Info

Product

Resources

About