Expression of hormone receptors, adipophilin, and GCDFP‐15 in mucinous carcinoma of the skin

Sung, You‐Na; Park, Chan-Sik; Roh, Jin; Choi, Jongwoo; Choi, Seungho; Lee, Yoonse; Cho, Kyung–Ja

doi:10.1111/cup.13349

Cited by 7 publications

(14 citation statements)

References 20 publications

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“…Immunohistochemistry plays a key role in characterizing PMCS and differentiating it from metastatic mucinous carcinomas of the skin. 8,13,21,25,26,29,35–42 Mucinous adenocarcinomas commonly metastasizing to the skin, include gastrointestinal tract and breast. PMCS are usually positive for pan-cytokeratin (AE1/AE3), Cam 5.2, BerEP4, cytokeratin 7, EMA, pCEA, and estrogen and progesterone receptors.…”

Section: Discussionmentioning

confidence: 99%

Primary Mucinous Carcinoma of Skin: A Rare Cutaneous Neoplasm. Clinicopathologic Features, Differential Diagnoses, and Review of Literature

Tinguria

2023

The American Journal of Dermatopathology

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Primary mucinous carcinoma of the skin (PMCS) is a rare malignant neoplasm of sweat gland origin, with an incidence of 0.07 per million. Histologically, it may be difficult to differentiate it from metastatic mucinous carcinomas of the skin. A case of PMCS is reported here in a 59-year-old woman who presented with a lesion on the right lower eyelid. Histological examination revealed features of mucinous adenocarcinoma. The main differential diagnosis was metastatic mucinous adenocarcinoma; however, the lack of colorectal and lung markers and the presence of focal in situ components were consistent with the diagnosis of PMCS. PMCS and breast mucinous carcinoma share immunohistochemical markers, such as GCDFP-15 and mammaglobin; however, focal in situ component with the presence of myoepithelial cells in the tumor ruled out metastatic mucinous carcinoma of breast origin. The subsequent mammograms did not reveal any breast lesions. Colonoscopy did not show any evidence of colonic malignancy, and imaging studies (CT scan) did not show any evidence of neoplasm in the body. These findings were in keeping with a diagnosis of PMCS. The present case emphasizes the importance of clinicopathological correlation, histopathology, and immunohistochemistry in the accurate diagnosis of PMCS and summarizes the literature on these rare cutaneous neoplasms.

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Section: Discussionmentioning

confidence: 99%

Primary Mucinous Carcinoma of Skin: A Rare Cutaneous Neoplasm. Clinicopathologic Features, Differential Diagnoses, and Review of Literature

Tinguria

2023

The American Journal of Dermatopathology

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“…The role of adjuvant therapy remains unclear. Most tumors are resistant to radiotherapy and chemotherapy [ 11 , 54 , 57 , 80 , 88 , 97 , 294 , 300 ]. Primary or adjuvant radiotherapy may be considered in patients with microcystic adnexal carcinoma, and some cases of syringocystadenocarcinoma papilliferum, malignant mixed tumor, digital papillary adenocarcinoma, or signet-ring cell/histiocytoid carcinoma were also treated with successful radiation therapy [ 3 , 43 , 47 , 82 , 112 , 116 , 117 , 170 , 171 , 198 ].…”

Section: Discussionmentioning

confidence: 99%

“…Lesions exhibit tumor nests suspended in abundant mucin pools with focal strands or nests of neoplastic cells infiltrating the dermis. Cells are characterized by bland cytological features and occasional mitoses [ 97 ]. Neuroendocrine differentiation and immunophenotype can be identified locally.…”

Section: Tumors With Apocrine and Eccrine Differentiationmentioning

confidence: 99%

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Current Diagnosis and Treatment Options for Cutaneous Adnexal Neoplasms with Apocrine and Eccrine Differentiation

Płachta

Kleibert

Czarnecka

et al. 2021

IJMS

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Adnexal tumors of the skin are a rare group of benign and malignant neoplasms that exhibit morphological differentiation toward one or more of the adnexal epithelium types present in normal skin. Tumors deriving from apocrine or eccrine glands are highly heterogeneous and represent various histological entities. Macroscopic and dermatoscopic features of these tumors are unspecific; therefore, a specialized pathological examination is required to correctly diagnose patients. Limited treatment guidelines of adnexal tumor cases are available; thus, therapy is still challenging. Patients should be referred to high-volume skin cancer centers to receive an appropriate multidisciplinary treatment, affecting their outcome. The purpose of this review is to summarize currently available data on pathogenesis, diagnosis, and treatment approach for apocrine and eccrine tumors.

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“…34,35 Primary cutaneous mucinous carcinoma also expresses other cytokeratins (AE1/AE3, CAM5.2) as well as epithelial membrane antigen (EMA), carcinoembryonic antigen (CEA), estrogen receptor (ER), progesterone receptor (PR), and GCDFP-15. 19,26,36,37 The expression of multiple breast markers (ER, PR, and GCDFP-15) makes PCMC difficult to differentiate from metastatic breast cancer on histopathologic and immunohistochemical grounds alone. 32 In these cases, the identification of a myoepithelial layer (in situ component) may help to confirm the cutaneous origin of the tumor.…”

Section: Histopathologymentioning

confidence: 99%

Primary Cutaneous Mucinous Carcinoma: A Review of the Literature

Freeman,

Russell,

Council

2023

Dermatol Surg

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BACKGROUND Primary cutaneous mucinous carcinoma (PCMC) is an exceedingly rare, low-grade tumor that histologically resembles mucinous carcinoma from other primary sites, such as the breast, gastrointestinal tract, and lungs. OBJECTIVE The purpose of this article was to review the current literature on PCMC as it relates to epidemiology, clinical presentation, histopathology, immunohistochemistry, treatment, and prognosis. MATERIALS AND METHODS An extensive literature review was conducted using PubMed and Ovid MEDLINE to identify articles related to PCMC. RESULTS Several hundred cases have been reported in the medical literature, and surgical resection, whenever feasible, is the standard of care. CONCLUSION The diagnosis of primary cutaneous mucinous carcinoma is one of exclusion, requiring a metastatic work-up to rule out distant primary. Mohs micrographic surgery is a tissue sparing technique that allows complete margin control of these rare neoplasia.

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Expression of hormone receptors, adipophilin, and GCDFP‐15 in mucinous carcinoma of the skin

Cited by 7 publications

References 20 publications

Primary Mucinous Carcinoma of Skin: A Rare Cutaneous Neoplasm. Clinicopathologic Features, Differential Diagnoses, and Review of Literature

Primary Mucinous Carcinoma of Skin: A Rare Cutaneous Neoplasm. Clinicopathologic Features, Differential Diagnoses, and Review of Literature

Current Diagnosis and Treatment Options for Cutaneous Adnexal Neoplasms with Apocrine and Eccrine Differentiation

Primary Cutaneous Mucinous Carcinoma: A Review of the Literature

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