Expression of Homeobox Genes in Cervical Cancer

Li, Hung; Huang, Chiu-Jung; Choo, Kong‐Bung

doi:10.1006/gyno.2001.6498

Cited by 26 publications

(23 citation statements)

References 42 publications

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“…HOXD9 in cervical cancer compared to undetected transcript in normal cervix; 10 7 An advance in elucidating the functional properties of HOX proteins in the transcriptional machinery has been the identification of DNA binding complexes between HOX proteins and another two non-HOX homeodomain proteins, PBX1 and MEIS1, both members of the TALE family. It has been established that HOX proteins in the paralogue groups 1-10, but not 11-13, form heterodimers with PBX1 and in this manner gain DNA binding specificity.…”

Section: B I O S C I E N C E 2 0 0 3 N O T F O R D I S T R I B U T mentioning

confidence: 99%

Altered HOX Gene Expression in Human Skin and Breast Cancer Cells

Svingen¹,

Tonissen²

2003

Cancer Biology & Therapy

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Human HOX genes are expressed in a spatio-temporal fashion during embryogenesis and early development where they act as master transcriptional regulators. HOX genes are also expressed in normal adult cells, potentially in a tissue specific manner involving maintenance of the normal phenotype. In selected oncogenic transformations, mis-expression of many HOX genes have been shown, indicating an involvement of these transcriptional regulators in carcinogenesis and metastasis. Utilising quantitative real-time RT-PCR assays, the expression of 20 HOX genes and two known HOX co-factors, PBX1B and MEIS1, were analysed in human melanoma and breast cancer cell lines, comparing results against non-malignant cells. Alterations in HOX gene expression were observed for all malignant cells examined, with some dysregulated transcript levels seemingly random, and the expression of other HOX genes apparently following the same patterns in both skin and breast cancer establishment. Furthermore, HOX gene expression was correlated with the invasive capacity of the cells. The expression of the HOX co-factors PBX1B and MEIS1 showed no marked changes from the non-malignant to the malignant phenotypes, further indicating that it is dysregulated HOX gene expression, rather than dysregulated gene expression of HOX co-factors, that potentially commit the cell to re-differentiate and undergo oncogenic transformation.

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Section: B I O S C I E N C E 2 0 0 3 N O T F O R D I S T R I B U T mentioning

confidence: 99%

Altered HOX Gene Expression in Human Skin and Breast Cancer Cells

Svingen¹,

Tonissen²

2003

Cancer Biology & Therapy

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“…Changes in the expression pattern of the HOX genes were found in colon, lung and cervical cancer, in malignant melanoma and in breast carcinoma (9,11,18,21,35).…”

Section: Discussionmentioning

confidence: 99%

“…It was associated with the invasive capacity of cancer cells (19). Other studies demonstrated that HOXD9 is inappropriately expressed in esophageal squamous cell carcinoma (20) and in cervical cancer (21).…”

Section: Introductionmentioning

confidence: 94%

Quantitative expression of the homeobox and integrin genes in human gastric carcinoma

Degl’Innocenti¹,

Castiglione²,

Buccoliero³

et al. 2007

Int J Mol Med

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Abstract. The homeobox (HOX) genes are a large family of regulator genes involved in the control of developmental processes and cell differentiation. The HOX genes encode transcription factors, and an increasing number of studies have shown that these genes may be implicated in the growth and the progression of many types of tumours. The present study investigated the expression of the HOX and integrin genes and their relationships in gastric carcinoma. We analyzed the RNA expression of 13 HOX genes from HOXA, C and D clusters and αV, α5 and α8 integrin genes in 24 gastric cancer samples by quantitative real-time PCR. The results showed that the HOXA2 gene and the α8 integrin gene had a lower expression in tumour samples than in normal gastric mucosas. The comparison between the HOX and integrin genes showed that HOXA2 and αV integrin expression presented the same trend in 83% of the samples. Moreover, in cancer samples that expressed the HOXD11 gene, the expression of αV integrin was lower with respect to normal mucosas. The different roles of HOX and integrin genes in gastric carcinoma remain to be fully elucidated. These findings suggest that the HOX genes may play a critical role in the genesis, maintenance and diffusion of gastric carcinoma.

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“…HOX proteins act as transcription factors in cooperation with other regulatory proteins, including PBX2, and are involved in the control of developmental processes and cell differentiation (1,2). Aberrant overexpression of HOX genes has been reported in various kinds of cancers, such as oral squamous cell carcinoma, non-small cell lung carcinoma (NSCLC), ovarian carcinoma, esophageal squamous cell carcinoma (ESCC), gastric carcinoma (GC), hepatocellular carcinoma, prostate cancer, bladder cancer, and cervical cancer, together with acute lymphoblastic leukemia (3)(4)(5)(6)(7)(8)(9)(10)(11)(12). Overexpression of HOX proteins is correlated with poor prognosis in some cancers, such as acute myeloid leukemia (13,14).…”

Section: Introductionmentioning

confidence: 99%

Expression level of Pre B cell leukemia homeobox 2 correlates with poor prognosis of gastric adenocarcinoma and esophageal squamous cell carcinoma

Morii¹

2010

Int J Oncol

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Abstract. Pre B cell leukemia homeobox 2 (PBX2), a member of PBX family, acts as a co-factor of homeobox proteins to regulate proliferation and differentiation of tumor cells. Our recent study revealed prognostic significance of PBX2 expression in non-small cell lung carcinoma. The significance of PBX2 expression was examined in cases with gastric cancer (GC) and esophageal squamous cell carcinoma (ESCC), and the role of PBX2 in tumor behavior was evaluated in GC and ESCC cell lines of knocked-down PBX2 expression. Expression level of PBX2 was immunohistochemically examined in 94 patients of GC and 64 patients of ESCC. Staining intensity for PBX2 was categorized as equal to or stronger (level 1) and weaker (level 2) than that of endothelial cells. Cases with level 1 expression in more than 20% of tumor were defined as high and others low expression. Patients with low PBX2 expression showed a better prognosis than those with high expression in both GC and ESCC. Multivariate analysis revealed PBX2 expression to be an independent prognosticator for both GC and ESCC. Knocked-down expression of PBX2 in GC and ESCC cell lines resulted in decrease of in vitro colony formation and in vivo tumorigenic activities, but proliferative and invasive activities did not change. Under serum depletion, apoptotic cell proportion was higher in PBX2 knocked-down cells than in control cells. The knock-down of PBX2 reduced Bcl-2 expression. Taken together, the high expression level of PBX2 was an independent negative prognosticator for both GC and ESCC, and PBX2 might promote tumor growth through suppression of apoptosis.

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Expression of Homeobox Genes in Cervical Cancer

Cited by 26 publications

References 42 publications

Altered HOX Gene Expression in Human Skin and Breast Cancer Cells

Altered HOX Gene Expression in Human Skin and Breast Cancer Cells

Quantitative expression of the homeobox and integrin genes in human gastric carcinoma

Expression level of Pre B cell leukemia homeobox 2 correlates with poor prognosis of gastric adenocarcinoma and esophageal squamous cell carcinoma

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