Abstract:The purpose of the present study was to clarify kinetic aberrations and premalignant and malignant lesions of oral mucosa. Epithelial hyperplasia (EH), mild and moderate epithelial dysplasia (ED), carcinoma in situ (CIS), and squamous cell carcinoma (SCC) were evaluated for histone H3 mRNA, p53 protein (P53), cyclin D1, and cyclin B1. A few cases were positive for P53 and histone H3, but rarely coexpressed both in EH and ED. In CIS and SCC, increased expressions of P53 and histone H3 were seen, and there were … Show more
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