Expression of HIF-1α in pediatric asthmatic patients
Victor Gonzalez-Uribe,
Ricardo Martinez-Tenopala,
Alejandra Osorio-Martínez
et al.
Abstract:Background: Several studies have suggested that HIF-1α regulates eosinophil activity and induces epithelial inflammation via NF-κB activation in the pathophysiology of asthma. The purpose of this study was to examine the expression of the transcription factors HIF-1α and nuclear HIF in mononuclear cells obtained from peripheral blood samples of healthy pediatric patients, asthmatic patients, and asthmatic exacerbations, regardless of disease severity.Methods: HIF-1 levels were measured using immunocytochemistr… Show more
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