Expression of hepatic genes related to energy metabolism during the transition period of Holstein and F1 Holstein-Gir cows

Laguna, Juliana; Cardoso, Mariana Santos; Lima, Josiane Aparecida de; Reis, Ricardo; Carvalho, A.Ú.; Saturnino, H.M.; Teixeira, Silvana

doi:10.3168/jds.2016-12459

Cited by 9 publications

(7 citation statements)

References 46 publications

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“…In another examination, Laguna et al [ 87 ] examined the expression of genes that encode for the enzymes and different processes linked with the metabolism of lipids and carbohydrates of 2 genetic classes of dairy cows in the transition phase. Examination of the expression of cytosolic phosphoenolpyruvate carboxykinase ( PEPCK-C ), glucose-6-phosphatase (G6PC), β -hydroxybutyrate dehydrogenase-2 ( BDH2 ), methylmalonyl-CoA mutase ( MUT ), carnitine palmitoyltransferase-2 ( CPT2 ), acetyl-CoA carboxylase ( ACC ), glucose transporter-2 ( SLC2A2 ), 3-hydroxy-3-methylglutaryl-CoA reductase ( HMGCR ), and the transcription factor peroxisome proliferator-activated receptor α ( PPARA ) was directed, and a comparison was established between Holstein and F1 Holstein-Gir cows.…”

Section: Strategies To Alleviate Biological Stress During the Transit...mentioning

confidence: 99%

“…However, no significant difference in glucose level was observed within each group during the analysis period. β -Hydroxybutyrate and NEFA concentrations were not different in both genetic groups but showed a high level from prepartum to d 6 and 21 postpartum [ 87 ]. The altered expressions of these different genes in liver are linked with metabolic stress in transition dairy cows.…”

Section: Strategies To Alleviate Biological Stress During the Transit...mentioning

confidence: 99%

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Nutrigenomic Interventions to Address Metabolic Stress and Related Disorders in Transition Cows

Hassan

Nadeem

Javed

et al. 2022

BioMed Research International

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For dairy cattle, the period involving a shift from late pregnancy to early lactation termed transition or periparturient is an excruciating phase. Health-related disorders are likely to happen in this time frame. Timely postpartum and metabolic adjustments to this new physical state demands correct management strategies to fulfill the cow’s needs for a successful transition to this phase. Among the management strategies, one of the most researched methods for managing transition-related stress is nutritional supplementation. Dietary components directly or indirectly affect the expression of various genes that are believed to be involved in various stress-related responses during this phase. Nutrigenomics, an interdisciplinary approach that combines nutritional science with omics technologies, opens new avenues for studying the genome’s complicated interactions with food. This revolutionary technique emphasizes the importance of food-gene interactions on various physiological and metabolic mechanisms. In animal sciences, nutrigenomics aims to promote the welfare of livestock animals and enhance their commercially important qualities through nutritional interventions. To this end, an increasing volume of research shows that nutritional supplementation can be effectively used to manage the metabolic stress dairy cows undergo during the transition period. These nutritional supplements, including polyunsaturated fatty acids, vitamins, dietary amino acids, and phytochemicals, have been shown to modulate energy homeostasis through different pathways, leading to addressing metabolic issues in transition cows.

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Section: Strategies To Alleviate Biological Stress During the Transit...mentioning

confidence: 99%

Section: Strategies To Alleviate Biological Stress During the Transit...mentioning

confidence: 99%

Nutrigenomic Interventions to Address Metabolic Stress and Related Disorders in Transition Cows

Hassan

Nadeem

Javed

et al. 2022

BioMed Research International

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“…Crossbreeding in dairy cattle serves mainly for the improvement of functional traits and milk composition of Holstein herds [1][2][3][4][5][6] or uses beef-breed sires over dairy cows to increase income from sales of the beef-cross-dairy calves born on the dairy farm [7]. The majority of these studies, however, report only the results of the first crossbreeding generation (F1) in comparison with the purebred line(s), such as e.g., [8,9] for Holstein-Jersey, or [10] for Holstein-Montbeliarde and Holstein-Viking Red, [11] for Holstein-Gir, or [12] for Holstein-Simmental cows. Only the F1 can reach the maximum heterosis effect, which might improve the performance for most trait complexes, e.g., productivity, efficiency, reproduction, and/or vitality of the F1 offspring by surpassing the average of the parental lines [13].…”

Section: Introductionmentioning

confidence: 99%

Energy Balance Indicators during the Transition Period and Early Lactation of Purebred Holstein and Simmental Cows and Their Crosses

Knob

Neto

Schweizer

et al. 2021

Animals

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Crossbreeding in dairy cattle has been used to improve functional traits, milk composition, and efficiency of Holstein herds. The objective of the study was to compare indicators of the metabolic energy balance, nonesterified fatty acids (NEFA), beta-hydroxybutyrate (BHBA), glucose, body condition score (BCS) back fat thickness (BFT), as well as milk yield and milk composition of Holstein and Simmental cows, and their crosses from the prepartum period until the 100th day of lactation at the Livestock Center of the Ludwig Maximilians University (Munich, Germany). In total, 164 cows formed five genetic groups according to their theoretic proportion of Holstein and Simmental genes as follows: Holstein (100% Holstein; n = 9), R1-Hol (51–99% Holstein; n = 30), first generation (F1) crossbreds (50% Holstein, 50% Simmental; n = 17), R1-Sim (1–49% Holstein; n = 81) and Simmental (100% Simmental; n = 27). The study took place between April 2018 and August 2019. BCS, BFT blood parameters, such as BHBA, glucose, and NEFA were recorded weekly. A mixed model analysis with fixed effects breed, week (relative to calving), the interaction of breed and week, parity, calving year, calving season, milking season, and the repeated measure effect of cow was used. BCS increased with the Simmental proportion. All genetic groups lost BCS and BFT after calving. Simmental cows showed lower NEFA values. BHBA and glucose did not differ among genetic groups, but they differed depending on the week relative to calving. Simmental and R1-Sim cows showed a smaller effect than the other genetic groups regarding changes in body weight, BCS, or back fat thickness after a period of a negative energy balance after calving. There was no significant difference for milk yield among genetic groups, although Simmental cows showed a lower milk yield after the third week after calving. Generally, Simmental and R1-Simmental cows seemed to deal better with a negative energy balance after calving than purebred Holstein and the other crossbred lines. Based on a positive heterosis effect of 10.06% for energy corrected milk (ECM), the F1, however, was the most efficient crossbred line.

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“…There was little difference in the abundance of PEPCK mRNA between −7 d and 14 d relative to calving. Laguna et al [34] reported similar findings for the mRNA abundance of cytosolic PEPCK in dairy cows during the transition period. These results indicate that PC is more susceptible to EB than PEPCK, and that PEPCK is a more important rate-limiting enzyme involved in glucose production than PC.…”

Section: Discussionmentioning

confidence: 54%

Effect of reduced energy density of close-up diets on metabolites, lipolysis and gluconeogenesis in Holstein cows

Huang

Wang

et al. 2019

Asian-Australas J Anim Sci

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Objective An experiment was conducted to determine the effect of reduced energy density of close-up diets on metabolites, lipolysis and gluconeogenesis in cows during the transition period. Methods Thirty-nine Holstein dry cows were blocked and assigned randomly to three groups, fed a high energy density diet (HD, 1.62 Mcal of net energy for lactation [NE L ]/kg dry matter [DM]), a medium energy density diet (MD, 1.47 Mcal NE L /kg DM), or a low energy density diet (LD, 1.30 Mcal NE L /kg DM) prepartum; they were fed the same lactation diet to 28 days in milk (DIM). All the cows were housed in a free-stall barn and fed ad libitum . Results The reduced energy density diets decreased the blood insulin concentration and increased nonesterified fatty acids (NEFA) concentration in the prepartum period (p<0.05). They also increased the concentrations of glucose, insulin and glucagon, and decreased the concentrations of NEFA and β-hydroxybutyrate during the first 2 weeks of lactation (p<0.05). The plasma urea nitrogen concentration of both prepartum and postpartum was not affected by dietary energy density (p>0.05). The dietary energy density had no effect on mRNA abundance of insulin receptors, leptin and peroxisome proliferator-activated receptor-γ in adipose tissue, and phosphoenolpyruvate carboxykinase, carnitine palmitoyltransferase-1 and peroxisome proliferator-activated receptor-α in liver during the transition period (p>0.05). The HD cows had higher mRNA abundance of hormone-sensitive lipase at 3 DIM compared with the MD cows and LD cows (p = 0.001). The mRNA abundance of hepatic pyruvate carboxykinase at 3 DIM tended to be increased by the reduced energy density of the close-up diets (p = 0.08). Conclusion The reduced energy density diet prepartum was effective in controlling adipose tissue mobilization and improving the capacity of hepatic gluconeogenesis postpartum.

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Expression of hepatic genes related to energy metabolism during the transition period of Holstein and F1 Holstein-Gir cows

Cited by 9 publications

References 46 publications

Nutrigenomic Interventions to Address Metabolic Stress and Related Disorders in Transition Cows

Nutrigenomic Interventions to Address Metabolic Stress and Related Disorders in Transition Cows

Energy Balance Indicators during the Transition Period and Early Lactation of Purebred Holstein and Simmental Cows and Their Crosses

Effect of reduced energy density of close-up diets on metabolites, lipolysis and gluconeogenesis in Holstein cows

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