Expression of heparan sulfate in gastric carcinoma and its correlation with clinicopathological features and patient survival

Lo, Soo-Ling; Thike, Aye Aye; Tan, Soo‐Yong; Lim, Tony Kiat-Hon; Tan, Iain Beehuat; Choo, Su-Pin; Tan, Puay‐Hoon; Bay, Boon‐Huat; Yip, George

doi:10.1136/jcp.2010.087478

Cited by 8 publications

(4 citation statements)

References 64 publications

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“…In addition, we found that PTK7 expression was associated with differentiation and survival in gastric cancer patients. Similar reports demonstrated that some prognostic markers were associated with differentiation 18, 19. Several important differentiation‐related factors also have been linked with gastric cancer survival 20, 21.…”

Section: Discussionsupporting

confidence: 68%

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PTK7 as a novel marker for favorable gastric cancer patient survival

Lin

Zhang

Wang

et al. 2012

Journal of Surgical Oncology

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Section: Discussionsupporting

confidence: 68%

“…The human PTK7 gene is located in a region (6p21.1–p12.2) of the chromosome where deletions and duplications are frequently found among patients with developmental disorders and several cancers 18, 22. It has been proven that PTK7 inhibits tube formation as well as the migration and invasion of endothelial cells and angiogenesis 23.…”

Section: Discussionmentioning

confidence: 99%

PTK7 as a novel marker for favorable gastric cancer patient survival

Lin

Zhang

Wang

et al. 2012

Journal of Surgical Oncology

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“…41 Genetic incorporation of poly-lysines and Arg-Gly-Asp (RGD) peptides into the fiber knob makes it possible for a recombinant Ad to infect vi a heparan sulfate and α v -integrins, respectively 42–44 ; however, downregulation of heparin sulfate was reported in several types of tumors. 45 , 46 Although fiber-modified conditionally replicating Ads containing RGD peptides in the fiber knob infect CTCs via interaction with α v -integrins, CD46 is an infection receptor suitable for infection of CTCs with conditionally replicating Ads because CD46 was upregulated in malignant tumor cells. 19 , 20 In addition, CD46 was not downregulated under TGF-β–induced EMT ( Figure 4 ).…”

Section: Discussionmentioning

confidence: 99%

Efficient detection of human circulating tumor cells without significant production of false-positive cells by a novel conditionally replicating adenovirus

Sakurai

Narii

Tomita

et al. 2016

Molecular Therapy - Methods & Clinical Development

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Circulating tumor cells (CTCs) are promising biomarkers in several cancers, and thus methods and apparatuses for their detection and quantification in the blood have been actively pursued. A novel CTC detection system using a green fluorescence protein (GFP)–expressing conditionally replicating adenovirus (Ad) (rAd-GFP) was recently developed; however, there is concern about the production of false-positive cells (GFP-positive normal blood cells) when using rAd-GFP, particularly at high titers. In addition, CTCs lacking or expressing low levels of coxsackievirus–adenovirus receptor (CAR) cannot be detected by rAd-GFP, because rAd-GFP is constructed based on Ad serotype 5, which recognizes CAR. In order to suppress the production of false-positive cells, sequences perfectly complementary to blood cell–specific microRNA, miR-142-3p, were incorporated into the 3′-untranslated region of the E1B and GFP genes. In addition, the fiber protein was replaced with that of Ad serotype 35, which recognizes human CD46, creating rAdF35-142T-GFP. rAdF35-142T-GFP efficiently labeled not only CAR-positive tumor cells but also CAR-negative tumor cells with GFP. The numbers of false-positive cells were dramatically lower for rAdF35-142T-GFP than for rAd-GFP. CTCs in the blood of cancer patients were detected by rAdF35-142T-GFP with a large reduction in false-positive cells.

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“…High levels of CS showed prognostic capacity in breast [128] and ovarian cancers [130]. High expression levels of HS signaled poor prognosis in patients with gastric carcinoma [131]. Higher levels of HA were associated with poor survival in patients with breast cancer [133], acute myeloid leukemia [134], and prostate cancer [132].…”

Section: Gags and Gps In Diagnosis And Prognosismentioning

confidence: 99%

Roles of Proteoglycans and Glycosaminoglycans in Cancer Development and Progression

Wei

Huang

et al. 2020

IJMS

110

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The extracellular matrix (ECM) spatiotemporally controls cell fate; however, dysregulation of ECM remodeling can lead to tumorigenesis and cancer development by providing favorable conditions for tumor cells. Proteoglycans (PGs) and glycosaminoglycans (GAGs) are the major macromolecules composing ECM. They influence both cell behavior and matrix properties through direct and indirect interactions with various cytokines, growth factors, cell surface receptors, adhesion molecules, enzymes, and glycoproteins within the ECM. The classical features of PGs/GAGs play well-known roles in cancer angiogenesis, proliferation, invasion, and metastasis. Several lines of evidence suggest that PGs/GAGs critically affect broader aspects in cancer initiation and the progression process, including regulation of cell metabolism, serving as a sensor of ECM’s mechanical properties, affecting immune supervision, and participating in therapeutic resistance to various forms of treatment. These functions may be implemented through the characteristics of PGs/GAGs as molecular bridges linking ECM and cells in cell-specific and context-specific manners within the tumor microenvironment (TME). In this review, we intend to present a comprehensive illustration of the ways in which PGs/GAGs participate in and regulate several aspects of tumorigenesis; we put forward a perspective regarding their effects as biomarkers or targets for diagnoses and therapeutic interventions.

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Expression of heparan sulfate in gastric carcinoma and its correlation with clinicopathological features and patient survival

Abstract: The data suggest that heparan sulfate may play an important role in regulating the biology of gastric cancer, and that it may be a useful prognostic marker of this tumour.

Cited by 8 publications

References 64 publications

PTK7 as a novel marker for favorable gastric cancer patient survival

PTK7 as a novel marker for favorable gastric cancer patient survival

Efficient detection of human circulating tumor cells without significant production of false-positive cells by a novel conditionally replicating adenovirus

Roles of Proteoglycans and Glycosaminoglycans in Cancer Development and Progression

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