Expression of Heat Shock Protein 27 with the Transition from Proliferation to Differentiation of Acinar Precursor Cell in Regenerating Submandibular Gland of Rats

Takahashi-Horiuchi, Yuko; Sugiyama, Kanji; Sakashita, Hideaki; Amano, Osamu

doi:10.1620/tjem.214.221

Cited by 17 publications

(20 citation statements)

References 36 publications

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“…During the subsequent development of salivary gland tissue , terminal tubule cells become active and proliferate from birth to the age of 2 weeks. By the age of 3 weeks, the acinar portion makes up most of the mature salivary gland tissue, and the terminal portion has mostly disappeared [5, 8, 29]. Therefore, terminal tubule cells are considered to differentiate into acinar cells (i.e., show precursor cell-like characteristics) [37].…”

Section: Discussionmentioning

confidence: 99%

Expression of c-kit and Cytokeratin 5 in the Submandibular Gland after Release of Long-Term Ligation of the Main Excretory Duct in Mice

Watanabe

Takahashi

Hata-Kawakami

et al. 2017

Acta Histochem. Cytochem

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Long-term submandibular duct obstruction is thought to cause irreversible atrophy and dysfunction of the submandibular gland. As an atrophic gland may be induced clinically by chronic or recurrent infection, it is generally removed surgically. However, the regenerative capacity of atrophic submandibular glands after long-term obstruction is not completely understood. We studied the regenerative capacity of the mouse submandibular duct using an aneurysm clip ligation model. We documented changes in the size, histologic structure and gene expression of the submandibular gland after 2 months of ligation, and 1 week, 1 month and 2 months after clip removal. Two months of ligation caused atrophy, particularly in the acinar portion. In the 2 months after clip removal, we observed a steady and significant increase in the expression of the acinar cell precursor gene cytokeratin 5 (CK5), and a significant decrease in the expression of the stem cell marker c-kit. These findings suggest that the submandibular gland retains some capacity for regeneration even after long-term obstruction, and that CK5 could serve as a marker of this regenerative process.

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Section: Discussionmentioning

confidence: 99%

Expression of c-kit and Cytokeratin 5 in the Submandibular Gland after Release of Long-Term Ligation of the Main Excretory Duct in Mice

Watanabe

Takahashi

Hata-Kawakami

et al. 2017

Acta Histochem. Cytochem

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“…Moreover, the profiles of the secretory granules in the TT and ID cells are very similar, thus suggesting that granular ID cells are of TT origin and may hide potent proliferative and differentiation capability in mature salivary glands under physiological conditions. In duct-ligated submandibular glands of rats, Hsp27-positive epithelial cells are substantially but temporarily induced after the ligation is stopped [41]. These data strongly suggest that the ID include the precursor or stem cells of the salivary glands.…”

Section: The Duct and Acinar Systems Of Salivary Glandsmentioning

confidence: 99%

Anatomy and Histology of Rodent and Human Major Salivary Glands—Overview of the Japan Salivary Gland Society-Sponsored Workshop—

Amano

Mizobe

Bando

et al. 2012

Acta Histochem. Cytochem.

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207

150

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Major salivary glands of both humans and rodents consist of three pairs of macroscopic glands: parotid, submandibular, and sublingual. These glands secrete serous, mucous or mixed saliva via the proper main excretory ducts connecting the glandular bodies with the oral cavity. A series of discoveries about the salivary ducts in the 17th century by Niels Stensen (1638–1686), Thomas Wharton (1614–1673), and Caspar Bartholin (1655–1738) established the concept of exocrine secretion as well as salivary glands. Recent investigations have revealed the endocrine functions of parotin and a variety of cell growth factors produced by salivary glands.The present review aims to describe macroscopic findings on the major salivary glands of rodents and the microscopic differences between those of humans and rodents, which review should be of interest to those researchers studying salivary glands.

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“…Moreover, the level of HSP25 increased after the peak of proliferation in rat acinar cells, whereas it decreased following differentiation. Both proliferative cells and differentiated cells showed negative HSP25-immunoreactivity (Takahashi-Horiuchi et al, 2008). In contrast, other studies showed that HSP25 was expressed in undifferentiated EC and embryonic stem (ES) cells, but suddenly decreased when those cells became differentiated (Battersby et al, 2007;Davidson et al, 2008).…”

Section: Discussionmentioning

confidence: 97%

HSP25 Affects the Proliferation and Differentiation of Rat Dental Follicle Cells

Gong

et al. 2009

Int J Oral Sci

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Expression of Heat Shock Protein 27 with the Transition from Proliferation to Differentiation of Acinar Precursor Cell in Regenerating Submandibular Gland of Rats

Cited by 17 publications

References 36 publications

Expression of c-kit and Cytokeratin 5 in the Submandibular Gland after Release of Long-Term Ligation of the Main Excretory Duct in Mice

Expression of c-kit and Cytokeratin 5 in the Submandibular Gland after Release of Long-Term Ligation of the Main Excretory Duct in Mice

Anatomy and Histology of Rodent and Human Major Salivary Glands—Overview of the Japan Salivary Gland Society-Sponsored Workshop—

HSP25 Affects the Proliferation and Differentiation of Rat Dental Follicle Cells

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