Expression of group II metabotropic glutamate receptors in rat superior cervical ganglion

Wei, Xixi; Zhao, Chenlu; Jia, Xinyun; Zhao, Baosheng; Liu, Yuzhen

doi:10.1016/j.autneu.2022.103053

Cited by 1 publication

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References 35 publications

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“…Another research group explored the role of glutamate in OSA pathogenesis by studying the expression of metabotropic glutamate receptors in superior cervical ganglion (SCG) in rats – an important blood pressure regulator. The expression of mGluR2/3 detected in SCG has been lowered after the exposure of rats to chronic intermittent hypoxia ( Wei et al, 2023 ). This may lead to a conclusion that changes in the glutamate neurotransmission in SCG due to chronic intermittent hypoxia in OSA may be responsible for an increase in blood pressure.…”

Section: Influence Of Inhibitory/excitatory Neurotransmission On Osamentioning

confidence: 99%

Influence of glutamatergic and GABAergic neurotransmission on obstructive sleep apnea

et al. 2023

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Glutamate and γ-aminobutyric acid (GABA) are the two main neurotransmitters in the human brain. The balance between their excitatory and inhibitory functions is crucial for maintaining the brain’s physiological functions. Disturbance of glutamatergic or GABAergic neurotransmission leads to serious health problems including neurodegeneration, affective and sleep disorders. Both GABA and glutamate are involved in the control of the sleep–wake cycle. The disturbances in their function may cause sleep and sleep-related disorders. Obstructive sleep apnea (OSA) is the most common sleep respiratory disorder and is characterized by repetitive collapse of the upper airway resulting in intermittent hypoxia and sleep fragmentation. The complex pathophysiology of OSA is the basis of the development of numerous comorbid diseases. There is emerging evidence that GABA and glutamate disturbances may be involved in the pathogenesis of OSA, as well as its comorbidities. Additionally, the GABA/glutamate targeted pharmacotherapy may also influence the course of OSA, which is important in the implementation of wildly used drugs including benzodiazepines, anesthetics, and gabapentinoids. In this review, we summarize current knowledge on the influence of disturbances in glutamatergic and GABAergic neurotransmission on obstructive sleep apnea.

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Section: Influence Of Inhibitory/excitatory Neurotransmission On Osamentioning

confidence: 99%

Influence of glutamatergic and GABAergic neurotransmission on obstructive sleep apnea

et al. 2023

View full text Add to dashboard Cite

show abstract

Expression of group II metabotropic glutamate receptors in rat superior cervical ganglion

Cited by 1 publication

References 35 publications

Influence of glutamatergic and GABAergic neurotransmission on obstructive sleep apnea

Influence of glutamatergic and GABAergic neurotransmission on obstructive sleep apnea

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