Expression of GRK2 and IGF1R in hepatocellular carcinoma: clinicopathological and prognostic significance

Lin, Shen; Zhou, Li; Zeng, Liang; Zhou, Weixun; Jin, Yongfeng

doi:10.1136/jclinpath-2016-203998

Cited by 19 publications

(18 citation statements)

References 36 publications

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“…Univariate analysis indicated that high IGF1R expression predicted poor overall and disease-free survival for patients with HCC. In multivariate analysis, IGF1R is significant in the overall survival of patients with HCC (24). Functional experiments demonstrated that IGF1R Figure 6.…”

Section: Discussionmentioning

confidence: 99%

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MicroRNA‑495 suppresses cell proliferation and invasion of hepatocellular carcinoma by directly targeting insulin‑like growth factor receptor‑1

Zhuang

Wang

et al. 2017

Exp Ther Med

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Abstract. Hepatocellular carcinoma (HCC) is the fifth most common malignancy and second-most frequent cause of cancer-associated deaths worldwide. Previously, increasing studies report that microRNAs (miRNAs/miRs) are abnormally expressed in various types of human cancers and may participate in the tumourigenesis and tumour development of HCC. miRNA-based targeted therapy is effective against different molecular targets and may increase the sensitisation of cancer cells to therapy by several folds. Therefore, further validation of potentially important miRNAs involved in HCC initiation and progression may provide valuable insights into the treatment of patients with HCC. miR-495 is abnormally expressed in multiple types of human cancers. However, the expression level and roles of miR-495 in HCC have yet to be completely elucidated. In the present study, miR-495 expression was frequently downregulated in HCC tissues and cell lines, and miR-495 expression levels were significantly correlated with tumour size, tumor-node-metastasis (TNM) stage and lymph node metastasis in patients with HCC. Functional assays revealed that miR-495 overexpression inhibited cell proliferation and invasion in HCC. Insulin-like growth factor receptor-1 (IGF1R) was identified as a direct target gene of miR-495 in HCC. IGF1R was upregulated in HCC tissues and negatively correlated with miR-495 expression level. The upregulation of IGF1R rescued the miR-495-induced tumour-suppressive roles in HCC cell proliferation and invasion, and the restored miR-495 expression inactivated the protein kinase B and extracellular regulated protein kinase signalling pathways in HCC. These results provide novel insights into the molecular mechanism underlying HCC progression, and suggest that miR-495 may be investigated as a novel therapeutic target for patients with this disease.

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Section: Discussionmentioning

confidence: 99%

“…IGF1R, which is highly expressed in HCC and possibly involved in HCC formation and progression (24,25), was predicted as a potential target of miR-495 (Fig. 3A) and consequently selected for further experimental validation.…”

Section: Igf1r Is a Direct Downstream Target Of Mir-495 In Hccmentioning

confidence: 99%

MicroRNA‑495 suppresses cell proliferation and invasion of hepatocellular carcinoma by directly targeting insulin‑like growth factor receptor‑1

Zhuang

Wang

et al. 2017

Exp Ther Med

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“…Lin et al [23] stated similar results to us and recorded that Apo A1 sensitivity was 45% and specificity was 56% at cutoff level of 46 mg/dL.…”

Section: Discussionsupporting

confidence: 80%

“…In cases of HCC, it was recorded to be 17-53 ng/dL with mean level 32.6 mg/ dL which was agreed by Lin et al [23] who stated IGF1R level in his study to reach 33 ng/dL. In cases of cirrhotic patients, the level was decreased ranging between 17 and 53 ng/dL with a mean level 35.1 mg/dL which was agreed by Yang et al [13] and Kasprzak et al [21] who recorded the level to be 16 and 63 ng/dL, respectively.…”

Section: Discussionsupporting

confidence: 77%

Evaluation of serum protein markers in diagnosis of hepatocellular carcinoma and carcinogenesis risk assessment in chronic liver disease patients

Hegazy¹,

Eissa²,

Sorour³

et al. 2017

APJTD

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“…Its sensitivity for HCC screening ranges from 41 to 65% at a cutoff of 20 ng/mL [53][54][55][56]. In recent years, various biomarkers have emerged for diagnosing HCC and predicting patient outcome, including glypican 3 and insulin-like growth factor (IGF)II mRNA [57], Keap1 and pNrf2 [58], 3-microRNA and AFP [59], CXCL1 [60], minichromosome maintenance complex -7 [61], and IGF1 receptor [62], among others.…”

Section: Discussionmentioning

confidence: 99%

NLRC and NLRX gene family mRNA expression and prognostic value in hepatocellular carcinoma

et al. 2017

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Nucleotide‐binding oligomerization domain (NOD)‐like receptor (NLR)C and NLRX family proteins play a key role in the innate immune response. The relationship between these proteins and hepatocellular carcinoma (HCC) remains unclear. This study investigated the prognostic significance of NLRC and NLRX family protein levels in HCC patients. Data from 360 HCC patients in The Cancer Genome Atlas database and 231 patients in the Gene Expression Omnibus database were analyzed. Kaplan–Meier analysis and a Cox regression model were used to determine median survival time (MST) and overall and recurrence‐free survival by calculating the hazard ratio (HR) and 95% confidence interval (CI). High NOD2 and low NLRX1 expression in tumor tissue was associated with short MST (P = 0.012 and 0.014, respectively). A joint‐effects analysis of NOD2 and NLRX1 combined revealed that groups III and IV had reduced risk of death from HCC as compared to group I (adjusted P = 0.001, adjusted HR = 0.31, 95% CI = 0.16–0.61 and adjusted P = 0.043, adjusted HR = 0.63, 95%CI = 0.41–0.99, respectively). NOD2 and NLRX1 expression levels are potential prognostic markers in HCC following hepatectomy.

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Expression of GRK2 and IGF1R in hepatocellular carcinoma: clinicopathological and prognostic significance

Abstract: Our data indicate that GRK2 and IGF1R show a negative correlation in HCC. IGF1R could be a potential marker of poor prognosis for this malignancy.

Cited by 19 publications

References 36 publications

MicroRNA‑495 suppresses cell proliferation and invasion of hepatocellular carcinoma by directly targeting insulin‑like growth factor receptor‑1

MicroRNA‑495 suppresses cell proliferation and invasion of hepatocellular carcinoma by directly targeting insulin‑like growth factor receptor‑1

Evaluation of serum protein markers in diagnosis of hepatocellular carcinoma and carcinogenesis risk assessment in chronic liver disease patients

NLRC and NLRX gene family mRNA expression and prognostic value in hepatocellular carcinoma

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