Expression of GPI-anchored SARS-CoV-2 receptor binding domain in mammalian cells for serological use

Abstract

Aim: Candida species causing neonatal candidaemia show a wide geographical variation and are usually healthcare acquired. Awareness of prevalent Candida species and knowledge of possible risk factors allows timely commencement of antifungal prophylaxis, directs appropriate empirical antifungal therapy and helps to prevent occurrence. This study aims to evaluate the Candida species distribution and the impact on preventive measures. Method: This was carried out as a prospective descriptive study in a Special Care Baby Unit (with a capacity of 16 cots with ventilation facilities for 8 newborns) attached to a tertiary care hospital in Colombo, Sri Lanka from January 2015 to December 2020. Identification and antifungal sensitivities were done according to standard protocols. Impact of preventive measures implemented to prevent nosocomial transmission of Candida species was reassessed. Result: A total of 27 candidaemia episodes (C. parapsilosis 61.54%, C. albicans 15.38%, C. guilliermondii 15.38% and 7.7% non-albicans Candida) were detected during the study period. The overall incidence was 1.04 per 100 SCBU admissions. A drop in antibiotic consumption was noted with antibiotic stewardship implementation. Discussion: Neonatal candidaemia was predominantly caused by non-albicans Candida species. Implementation of antibiotic stewardship programme and strengthening of infection control activities markedly reduced the incidence of neonatal candidaemia.