Expression of glucocorticoid receptors in the hippocampal region of the rat brain during postnatal development

Galeeva, Anastasia; Ordyan, N. É.; Pivina, S. G.; Pelto‐Huikko, Markku

doi:10.1016/j.jchemneu.2006.01.004

Cited by 27 publications

(24 citation statements)

References 55 publications

(71 reference statements)

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“…Furthermore, changes in abundance of multiple GR protein isoforms across rodent hippocampal development have been described. 60 In our previous study of human GR mRNA expression, dynamic regulation was seen in the cortex, but not in the hippocampus, with higher expression being observed in grey matter layers II-VI of the DLPFC in adolescent and adult groups than in infant or aged groups. 61 The generalizability and significance of these findings are limited because initial observations have not been replicated, did not include toddler and school-age individuals, and did not extend to the study of the abundance and localization of GR protein.…”

Section: Introductionmentioning

confidence: 78%

Dynamic molecular and anatomical changes in the glucocorticoid receptor in human cortical development

et al. 2010

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The glucocorticoid receptor (GR) has a critical role in determining the brain's capacity to respond to stress, and has been implicated in the pathogenesis of psychiatric illness. We hypothesized that key changes in cortical GR occur during adolescence and young adulthood, at a time when individuals are at increased risk of developing schizophrenia, bipolar disorder and major depression. We investigated the mRNA and protein expression of GR in the dorsolateral prefrontal cortex across seven developmental time points from infancy to adulthood. GR mRNA expression, determined by microarray and quantitative real-time PCR, was lowest in neonates and peaked around young adulthood. Western blotting revealed two dynamic patterns of GRa protein expression across the lifespan, with N-terminal variants displaying differing unique patterns of abundance. GRa-A and a 67-kDa GRa isoform mirrored mRNA trends and peaked in toddlers and late in adolescence, whereas a 40-kDa isoform, very likely a GRa-D variant, peaked in neonates and decreased across the lifespan. GRa protein was localized to pyramidal neurons throughout life and most strikingly in young adulthood, but to white matter astrocytes only in neonates and infants ( < 130 days). These results suggest that the neonatal and late adolescent periods represent critical windows of stress pathway development, and highlight the importance of white matter astrocytes and pyramidal neurons, respectively, at these stages of cortical development. Evidence of dynamic patterns of GR isoform expression and cellular localization across development strengthens the hypothesis that windows of vulnerability to stress exist across human cortical development.

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Section: Introductionmentioning

confidence: 78%

Dynamic molecular and anatomical changes in the glucocorticoid receptor in human cortical development

et al. 2010

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“…Although the underlying mechanisms of the transient increase of microglial area in the CA1 are unclear, possible pathways, such as neuronal and humoral pathways from the oral cavity to the hippocampus, were recently reviewed (Ono et al 2010). One possibility is that the increased plasma corticosterone after increasing the vertical dimension is detected by corticosteroid receptors localized in neurons of the hippocampal formation (Han et al 2005;Galeeva et al 2006;Sarabdjitsingh et al 2009) and that such neurons affect microglia. Alternatively, the increased corticosterone directly affects microglia, which also express corticosteroid receptors (Tanaka et al 1997).…”

Section: Discussionmentioning

confidence: 99%

Occlusal Disharmony in Mice Transiently Activates Microglia in Hippocampal CA1 Region but Not in Dentate Gyrus

Kojo

Yamada

Kubo

et al. 2010

Tohoku J. Exp. Med.

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“…Hippocampal function is linked with stress response and is involved in the regulation of the HPA axis activity. 11,12) Stress-induced excess secretion of glucocorticoids affects excitatory glutamatergic neurotransmission in the hippocampus, which plays a key role for not only abnormal behavior but also cognitive disturbance. [13][14][15] YKS and its ingredients ameliorates enhanced glutamate neurotransmission in the hippocampus under stressful circumstances.…”

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confidence: 99%

Yokukansan, a Herbal Medicine in Japan, Buffers Social Crowding Stress <i>via</i> Ameliorating Glucocorticoid Secretion Response to Vasopressin

Tamano

Morioka

Iwaki

et al. 2018

Biological & Pharmaceutical Bulletin

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On the basis of the data that yokukansan (YKS), a herbal medicine, ameliorates aggressive behavior and abnormal glucocorticoid secretion of socially isolated mice under zinc deficiency, we tested whether YKS preventively buffers crowding stress-induced attenuations of glucocorticoid secretion response and longterm potentiation (LTP), an index of cognition. YKS-containing water was administered during the period of exposure to social crowding stress for 3 weeks. Serum corticosterone level was not significantly modified by administration of YKS-containing water and was also not increased after social-crowding stress. When vasopressin was injected into crowding-stressed rats to assess corticosterone secretion via pituitary-adorenocortical axis activation, vasopressin-induced increase in serum corticosterone was significantly attenuated compared to non-stressed control rats, indicating that the pituitary-adrenocortical response to vasopressin is affected after exposure to crowding stress. Interestingly, administration of YKS-containing water rescued attenuation of vasopressin-induced increase in serum corticosterone. LTP at Schaffer collateral-CA1 pyramidal cells synapses was attenuated in the hippocampal slices from crowding-stressed rats, while administration of YKS-containing water rescued the attenuation. The present study demonstrates that intake of YKS rescues crowding stress-induced impairments of glucocorticoid secretion response to vasopressin and hippocampal LTP. The intake of YKS may be benefit to buffering chronic stress.Key words Yokukansan; social-crowding stress; hippocampus; pituitary-adrenocortical response; vasopressin; herbal medicine Yokukansan (YKS), a herbal medicine in Japan, is effective for medical treatment for behavioral and psychological symptoms of dementia (BPSD) such as agitation/aggression, irritability, hallucinations, depression and anxiety, which may be aggravated by environmental stress.1,2) The clinical effectiveness of YKS on BPSD was reported by Iwasaki et al. 3) After that, other clinical studies have demonstrated additional effectiveness of YKS on Alzheimer's-type and Parkinsonia dementia in regard with behavioral and psychological symptoms. 4-8)Zinc deficiency is closely related with behavioral and psychological symptoms.9) Isolation-induced aggressive behavior under zinc deficiency is ameliorated by intake of YKS. 10)Administration of YKS-containing water ameliorates the increase in the basal serum corticosterone concentration of zincdeficient mice, while serum corticosterone is almost the same concentration between the control and zinc-deficient mice after the resident-intruder (aggressive behavior) test, suggesting that zinc deficiency affects the response of corticosterone secretion induced by the test. On the other hand, administration of YKS significantly increases serum corticosterone concentration in zinc-deficient mice after the resident-intruder test and YKS ameliorates the decreased rate (%) of serum corticosterone concentration after the test to the basal conce...

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Expression of glucocorticoid receptors in the hippocampal region of the rat brain during postnatal development

Cited by 27 publications

References 55 publications

Dynamic molecular and anatomical changes in the glucocorticoid receptor in human cortical development

Dynamic molecular and anatomical changes in the glucocorticoid receptor in human cortical development

Occlusal Disharmony in Mice Transiently Activates Microglia in Hippocampal CA1 Region but Not in Dentate Gyrus

Yokukansan, a Herbal Medicine in Japan, Buffers Social Crowding Stress <i>via</i> Ameliorating Glucocorticoid Secretion Response to Vasopressin

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