Expression of glucocorticoid receptor and glucose transporter-1 during placental development in the diabetic rat

Korgun, Emin Türkay; Acar, Nuray; Satı, Leyla; Kipmen-Korgun, Dijle; Ozen, Asl; Unek, Gozde; Üstünel, İ̇smail; Demir, Ramazan

doi:10.5603/fhc.2011.0045

Cited by 11 publications

(8 citation statements)

References 30 publications

(41 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In human pregnancies with pre-gestational diabetes, SLC2A1/GLUT1 expression was found increased in term placenta [27], specifically in basal membrane preparations [28, 29]; however, the much longer pregnancy in human precludes a direct comparison to rodent pregnancies. Overall, our finding of increased placental Slc2a1/Glut1 expression over time in mouse placenta conforms to previous reports for human placental SLC2A1/GLUT1 expression [30], for sheep pregnancy [31, 32] and for rat [24] and mouse [33, 34].…”

Section: Discussionsupporting

confidence: 92%

“…A major finding of this study is that glucose transporter expression levels in the placenta were more affected by diet than by diabetes in the pregnant mouse dam. This result is parallel to several studies in the rat that found no difference in placental Slc2a1/Glut1 expression in the diabetic animal [22–24]. In contrast, a study with small sample number (n = 3) reported reduced Slc2a1/Glut1 expression at the RNA and protein levels in diabetic placenta of ICR mice at E12 [25]; and in the non-obese diabetic (NOD) mouse strain, differences in RNA but not protein levels were detected [26].…”

Section: Discussionsupporting

confidence: 90%

See 1 more Smart Citation

Maternal diet modulates placental nutrient transporter gene expression in a mouse model of diabetic pregnancy

et al. 2019

View full text Add to dashboard Cite

Diabetes in the mother during pregnancy is a risk factor for birth defects and perinatal complications and can affect long-term health of the offspring through developmental programming of susceptibility to metabolic disease. We previously showed that Streptozotocin-induced maternal diabetes in mice is associated with altered cell differentiation and with smaller size of the placenta. Placental size and fetal size were affected by maternal diet in this model, and maternal diet also modulated the risk for neural tube defects. In the present study, we sought to determine the extent to which these effects might be mediated through altered expression of nutrient transporters, specifically glucose and fatty acid transporters in the placenta. Our results demonstrate that expression of several transporters is modulated by both maternal diet and maternal diabetes. Diet was revealed as the more prominent determinant of nutrient transporter expression levels, even in pregnancies with uncontrolled diabetes, consistent with the role of diet in placental and fetal growth. Notably, the largest changes in nutrient transporter expression levels were detected around midgestation time points when the placenta is being formed. These findings place the critical time period for susceptibility to diet exposures earlier than previously appreciated, implying that mechanisms underlying developmental programming can act on placenta formation.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 90%

Maternal diet modulates placental nutrient transporter gene expression in a mouse model of diabetic pregnancy

et al. 2019

View full text Add to dashboard Cite

show abstract

“…GLUT1 does not play a pivotal role in diabetic pregnancies. However, placental growth abnormalities during diabetic pregnancy may be related with the amount of GR [145].…”

Section: The Effects Of Glucocorticoids On Placental Glucose Transpormentioning

confidence: 99%

The Effects of Glucocorticoids on Fetal and Placental Development

Korgun¹,

Ozmen²,

Unek³

et al. 2012

Glucocorticoids - New Recognition of Our Familiar Friend

Self Cite

View full text Add to dashboard Cite

“…Glucocorticoid receptor (GR) in enterocytes was recently reported to be essential for GC (glucocorticoid)‐induced glucose transport, which consequently contributed to induction of hyperglycemia in vivo . A study using placenta of a diabetic rat indicated that there might be a relationship between GR and GLUT1 expressions at the cellular level . Thus, it is very intriguingly for us to show for the first time that GR played a pivotal role in CUEDC2‐mediated GLUT3 transcription in cancer cells.…”

Section: Discussionmentioning

confidence: 99%

CUE domain‐containing protein 2 promotes the Warburg effect and tumorigenesis

et al. 2017

View full text Add to dashboard Cite

Cancer progression depends on cellular metabolic reprogramming as both direct and indirect consequence of oncogenic lesions; however, the underlying mechanisms are still poorly understood. Here, we report that CUEDC2 (CUE domain-containing protein 2) plays a vital role in facilitating aerobic glycolysis, or Warburg effect, in cancer cells. Mechanistically, we show that CUEDC2 upregulates the two key glycolytic proteins GLUT3 and LDHA via interacting with the glucocorticoid receptor (GR) or 14-3-3ζ, respectively. We further demonstrate that enhanced aerobic glycolysis is essential for the role of CUEDC2 to drive cancer progression. Moreover, using tissue microarray analysis, we show a correlation between the aberrant expression of CUEDC2, and GLUT3 and LDHA in clinical HCC samples, further demonstrating a link between CUEDC2 and the Warburg effect during cancer development. Taken together, our findings reveal a previously unappreciated function of CUEDC2 in cancer cell metabolism and tumorigenesis, illustrating how close oncogenic lesions are intertwined with metabolic alterations promoting cancer progression.

show abstract

Expression of glucocorticoid receptor and glucose transporter-1 during placental development in the diabetic rat

Cited by 11 publications

References 30 publications

Maternal diet modulates placental nutrient transporter gene expression in a mouse model of diabetic pregnancy

Maternal diet modulates placental nutrient transporter gene expression in a mouse model of diabetic pregnancy

The Effects of Glucocorticoids on Fetal and Placental Development

CUE domain‐containing protein 2 promotes the Warburg effect and tumorigenesis

Contact Info

Product

Resources

About